Research ArticleOriginal Article
Open Access

Effect of seminal redox status on lipid peroxidation, apoptosis and DNA fragmentation in spermatozoa of infertile Saudi males

Sabiha Fatima, Raheek Alwaznah, Ghadeer S. Aljuraiban, Samina Wasi, Manal Abudawood, Mahmoud Abulmeaty, Mohamed Y. Berika and Feda S. Aljaser
Saudi Medical Journal March 2020, 41 (3) 238-246; DOI: https://doi.org/10.15537/smj.2020.3.24975

References

  1. ↵
    1. Inhorn MC,
    2. Patrizio P
    (2015) Infertility around the globe:new thinking on the gender, and reproductive technology and global movement in 21st centuary. Hum Reprod Update 21:411–426.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Velu A,
    2. Prasad G
    (2017) Epidemiologic aspects of male infertility. Int J Reprod Contracept Obstet Gynecol 6:3362–3365.
    OpenUrl
  3. ↵
    1. AlEnezi H,
    2. Isa AM,
    3. Abu-Rafea B,
    4. Madbouly K,
    5. Binsaleh S
    (2014) Pattern of semen fluid abnormalities in male partners of infertile couples in Riyadh, Saudi Arabia. Can J Urol 21:7322–7325.
    OpenUrlPubMed
  4. ↵
    1. Binsaleh S,
    2. Al-Qahtani R,
    3. Madbouly K,
    4. Isa AM,
    5. Abu-Rafea B
    (2015) Evaluation of sperm DNA damage in men from infertile Saudi couples. J Reprod Med 60:135–140.
    OpenUrlPubMed
  5. ↵
    1. Al-Turki HA
    (2015) Prevalence of primary and secondary infertility from tertiary center in eastern Saudi Arabia. Middle East Fertil Soc J 20:237–240.
    OpenUrl
  6. ↵
    1. Patel AS,
    2. Leong JY,
    3. Ramasamy R
    (2017) Prediction of male infertility by the World Health Organization laboratory manual for assessment of semen analysis:A systematic review. Arab J Urol 16:96–102.
    OpenUrl
  7. ↵
    1. Barratt CLR,
    2. Björndahl L,
    3. De Jonge CJ,
    4. Lamb DJ,
    5. Osorio Martini F,
    6. et al.
    (2017) The diagnosis of male infertility:an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities. Hum Reprod Update 23:660–680.
    OpenUrlCrossRef
  8. ↵
    1. Alasmari W,
    2. Edris F,
    3. Albar Z,
    4. Gari A,
    5. Eskandar M,
    6. Al Fageah M,
    7. Zawawi S
    (2018) High proportion of abnormal semen characteristics among saudi infertile couples. Clin Med Diagn 8:14–18.
    OpenUrl
  9. ↵
    1. Amjad S,
    2. Baig M,
    3. Zahid N,
    4. Tariq S,
    5. Rehman R
    (2019) Association between leptin, obesity, hormonal interplay and male infertility. Andrologia 51:e13147.
    OpenUrl
  10. ↵
    1. Dorostghoal M,
    2. Kazeminejad SR,
    3. Shahbazian N,
    4. Pourmehdi M,
    5. Jabbari A
    (2017) Oxidative stress status and sperm DNA fragmentation in fertile and infertile men. Andrologia 49:e12762.
    OpenUrl
  11. ↵
    1. Sun J,
    2. Wang H,
    3. Liu B,
    4. Shi W,
    5. Shi J,
    6. Zhang Z,
    7. Xing J
    (2017) Rutin attenuates H2O2-induced oxidation damage and apoptosis in Leydig cells by activating PI3K/Akt signal pathways. Biomed Pharmacother 88:500–506.
    OpenUrl
  12. ↵
    1. Dutta S,
    2. Majzoub A,
    3. Agarwal A
    (2019) Oxidative stress and sperm function:A systematic review on evaluation and management. Arab J Urol 17:87–97.
    OpenUrl
  13. ↵
    1. Sabeti P,
    2. Pourmasumi S,
    3. Rahiminia T,
    4. Akyash F,
    5. Talebi AR
    (2016) Etiologies of sperm oxidative stress. Int J Reprod Biomed (Yazd) 14:231–240.
    OpenUrl
  14. ↵
    1. Zorov DB,
    2. Juhaszova M,
    3. Sollott SJ
    (2014) Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 94:909–950.
    OpenUrlCrossRefPubMed
  15. ↵
    1. Santini SJ,
    2. Cordone V,
    3. Mijit M,
    4. Tatone C,
    5. Amicarelli F,
    6. Di Emidio G
    (2018) Role of mitochondria in the oxidative stress induced by electromagnetic fields:focus on reproductive system. Oxid Med Cell Longev, 5076271.
  16. ↵
    1. Fatima S
    (2018) Novel Prospects Based on Oxidative/Nitrosative Stress in Health and Disease, Role of reactive oxygen species in male reproduction (INTECH publisher, Croatia).
  17. ↵
    1. Huang C,
    2. Cao X,
    3. Pang D,
    4. Li C,
    5. Luo Q,
    6. Zou Y,
    7. et al.
    (2018) Is male infertility associated with increased oxidative stress in seminal plasma?A-meta analysis. Oncotarget 9:24494–24513.
    OpenUrl
  18. ↵
    1. Guerriero G,
    2. Trocchia S,
    3. Abdel-Gawad FK,
    4. Ciarcia G
    (2014) Roles of reactive oxygen species in the spermatogenesis regulation. Front Endocrinol (Lausanne) 5:56.
    OpenUrl
  19. ↵
    1. Alahmar AT
    (2019) Role of oxidative stress in male infertility:An updated review. J Hum Reprod Sci 12:4–18.
    OpenUrl
  20. ↵
    1. Mustafa A,
    2. Alfaqih MA,
    3. Al-Shaboul O
    (2018) The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions. Exp Ther Med 16:2132–2137.
    OpenUrl
  21. ↵
    1. Prokhorova EA,
    2. Kopeina GS,
    3. Lavrik IN,
    4. Zhivotovsky B
    (2018) Apoptosis regulation by subcellular relocation of caspases. Sci Rep 8:12199.
    OpenUrl
  22. ↵
    1. WHO 2010 Semen analysis:Standard procedure
    In Examination and processing of human semen (Cambridg University Press, Cambridge), 5, pp 10–114.
  23. ↵
    1. Bisht S,
    2. Faiq M,
    3. Tolahunase M,
    4. Dada R
    (2017) Oxidative stress and male infertility. Nat Rev Urol 14:470–485.
    OpenUrlCrossRef
  24. ↵
    1. Wagner H,
    2. Cheng JW,
    3. Ko EY
    (2017) Role of reactive oxygen species in male infertility:An updated review of literature. Arab J Urol 16:35–43.
    OpenUrl
  25. ↵
    1. Atig F,
    2. Kerkeni A,
    3. Saad A,
    4. Ajina M
    (2017) Effects of reduced seminal enzymatic antioxidants on sperm DNA fragmentation and semen quality of Tunisian infertile men. J Assist Reprod Genet 34:373–381.
    OpenUrl
  26. ↵
    1. Van Tran L,
    2. Malla BA,
    3. Kumar S,
    4. Tyagi AK
    (2017) Polyunsaturated Fatty Acids in Male Ruminant Reproduction - A Review. Asian-Australas J Anim Sci 30:622–637.
    OpenUrl
  27. ↵
    1. Walters JLH,
    2. De Iuliis GN,
    3. Nixon B,
    4. Bromfield EG
    (2018) Oxidative Stress in the Male Germline:A Review of Novel Strategies to Reduce 4-Hydroxynonenal Production. Antioxidants (Basel) 7:pii:E132.
    OpenUrl
  28. ↵
    1. Hall SE,
    2. Aitken RJ,
    3. Nixon B,
    4. Smith ND,
    5. Gibb Z
    (2017) Electrophilic aldehyde products of lipid peroxidation selectively adduct to heat shock protein 90 and arylsulfatase A in stallion spermatozoa. Biol Reprod 96:107–121.
    OpenUrlCrossRefPubMed
  29. ↵
    1. Baker MA,
    2. Weinberg A,
    3. Hetherington L,
    4. Villaverde AI,
    5. Velkov T,
    6. BaellJ,
    7. et al.
    (2015) Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function. Biol Reprod 92:108.
    OpenUrlCrossRefPubMed
  30. ↵
    1. Barik G,
    2. Chaturvedula L,
    3. Bobby Z
    (2019) Role of Oxidative Stress and Antioxidants in Male Infertility:An Interventional Study. J Hum Reprod Sci 12:204–209.
    OpenUrl
  31. ↵
    1. Agarwal A,
    2. Virk G,
    3. Ong C,
    4. du Plessis SS
    (2014) Effect of oxidative stress on male reproduction. World J Mens Health 32:1–17.
    OpenUrl
  32. ↵
    1. Ni K,
    2. Spiess AN,
    3. Schuppe HC,
    4. Steger K
    (2016) The impact of sperm protamine deficiency and sperm DNA damage on human male fertility:a systematic review and meta-analysis. Andrology 4:789–99.
    OpenUrl
  33. ↵
    1. Engel KM,
    2. Springsguth CH,
    3. Grunewald S
    (2018) What happens to the unsuccessful spermatozoa?Andrology, 6:335–344.
  34. ↵
    1. Nakidkina AN,
    2. Kuzmina TI
    (2019) Apoptosis in Spermatozoa and Its Role in Deteriorating Semen Quality. Russ J Dev Biol 50:165–172.
    OpenUrl
  35. ↵
    1. Sá R,
    2. Cunha M,
    3. Rocha E,
    4. Barros A,
    5. Sousa M
    (2015) Sperm DNA fragmentation is related to sperm morphological staining patterns. Reprod Biomed Online 31:506–515.
    OpenUrl
  36. ↵
    1. Aydos OS,
    2. Yükselten Y,
    3. Kaplan F,
    4. Sunguroğlu A,
    5. Aydos K
    (2015) Analysis of the correlation between sperm DNA integrity and conventional semen parameters in infertile men. Turk J Urol 41:191–197.
    OpenUrl
    1. Binsaleh S,
    2. Al-Qahtani R,
    3. Madbouly K,
    4. Isa AM,
    5. Abu-Rafea B
    (2015) Evaluation of sperm DNA damage in men from infertile Saudi couples. J Reprod Med 60:135–140.
    OpenUrlPubMed
  38. ↵
    1. Al Omrani B,
    2. Al Eisa N,
    3. Javed M,
    4. Al Ghedan M,
    5. Al Matrafi H,
    6. Al Sufyan H
    (2018) Associations of sperm DNA fragmentation with lifestyle factors and semen parameters of Saudi men and its impact on ICSI outcome. Reprod Biol Endocrinol 16:49.
    OpenUrl
  39. ↵
    1. Agarwal A,
    2. Cho CL,
    3. Esteves SC,
    4. Majzoub A
    (2017) Current limitation and future perspective of sperm DNA fragmentation tests. Transl Androl Urol 6:S549–S552.
    OpenUrl
  40. ↵
    1. Majzoub A,
    2. Agarwal A
    (2017) Antioxidant therapy in idiopathic oligoasthenoteratozoospermia. Indian J Urol 33:207–214.
    OpenUrl
  41. ↵
    1. Al-Otaibi ST
    (2018) Male infertility among bakers associated with exposure to high environmental temperature at the work place. J Taibah Univ Med Sci 13:103–107.
    OpenUrl
Back to top

In this issue

Print
Download PDF
Email Article
Citation Tools
Bookmark this article

Jump to section

Keywords