Research ArticleOriginal Article
Open Access

Effects of androgens and estrogens on sirtuin 1 gene expression in human aortic endothelial cells

Takafumi Tsuchiya, Ayano Takei, Kyoko Tsujikado and Toshihiko Inukai
Saudi Medical Journal April 2020, 41 (4) 361-368; DOI: https://doi.org/10.15537/smj.2020.4.25006

References

  1. ↵
    1. Diamanti-Kandarakis E,
    2. Dattilo M,
    3. Macut D,
    4. Duntas L,
    5. Gonos ES,
    6. Goulis DG,
    7. et al.
    (2017) Mechanisms in endocrinology:Aging and aniti-aging:a combo-endocrinology overview. Eur J Endocrinol 176:R283–R308.
    OpenUrlAbstract/FREE Full Text
  2. ↵
    1. Moore RL,
    2. Dai Y,
    3. Faller DV
    (2012) Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer. J Endocrinol 213:37–48.
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Tsuchiya T,
    2. Endo A,
    3. Tsujikado K,
    4. Inukai T
    (2017) Involvement of resveratrol and ?-3 polyunsaturated fatty acids on sirtuin 1 gene expression in THP1 cells. Am J Med Sci 354:415–422.
    OpenUrl
  4. ↵
    1. Chen CY,
    2. Wu CC,
    3. Huang YC,
    4. Hung CF,
    5. Wang LJ
    (2018) Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life. Neuropsychiatr Dis Treat 14:2389–2399.
    OpenUrl
  5. ↵
    1. Fu M,
    2. Liu M,
    3. Sauve AA,
    4. Jiao X,
    5. Zhang X,
    6. Wu X,
    7. et al.
    (2006) Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol 26:8122–8135.
    OpenUrlAbstract/FREE Full Text
    1. Yang NC,
    2. Song TY,
    3. Chen MY,
    4. Hu ML
    (2011) Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD(+) level, SIRT1 activity and replicative lifespan of human Hs68 cells. Biogerontology 12:527–536.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Cen J,
    2. Zhang H,
    3. Liu Y,
    4. Deng M,
    5. Tang S,
    6. Liu W,
    7. et al.
    (2015) Anti-aging effect of estrogen on telomerase activity in ovariectomised rats-animal model for menopause. Gynecol Endocrinol 31:582–585.
    OpenUrl
  8. ↵
    1. Vasconsuelo A,
    2. Milanesi L,
    3. Boland R
    (2013) Actions of 17ß-estradiol and testosterone in the mitochondria and their implications in aging. Ageing Res Rev 12:907–917.
    OpenUrlCrossRefPubMed
  9. ↵
    1. Nawata H,
    2. Yanase T,
    3. Goto K,
    4. Okabe T,
    5. Ashida K
    (2002) Mechanism of action of anti-aging DHEA-S and the replacement of DHEA-S. Mech Ageing Dev 123:1101–1106.
    OpenUrlCrossRefPubMedWeb of Science
  10. ↵
    1. Lee CH,
    2. Su SC,
    3. Chiang CF,
    4. Chien CY,
    5. Hsu CC,
    6. Yu TY,
    7. et al.
    (2017) Estrogen modulates vascular smooth muscle cell function through downregulation of SIRT1. Oncotarget 8:110039–110051.
    OpenUrl
  11. ↵
    1. Kumar P,
    2. Taha A,
    3. Kale RK,
    4. Cowsik SM,
    5. Baquer NZ
    (2011) Physiological and biochemical effects of 17ßestradiol in aging female rat brain. Exp Gerontol 46:597–605.
    OpenUrlPubMed
  12. ↵
    1. Pinton G,
    2. Nilsson S,
    3. Moro L
    (2018) Targeting estrogen receptor beta (ERß) for treatment of ovarian cancer:importance of KDM6B and SIRT1 for ERßexpression and functionality. Oncogenesis 7:15.
    OpenUrl
  13. ↵
    1. Harada N,
    2. Yoda Y,
    3. Yotsumoto Y,
    4. Masuda T,
    5. Takahashi Y,
    6. Katsuki T,
    7. et al.
    (2018) Androgen signalingßexpands ß-cell mass in male rats and ß-cell androgen receptor is degraded under high-glucose conditions. Am J Physiol Endocrinol Metab 314:E274–E286.
    OpenUrl
  14. ↵
    1. Chakrabarti S,
    2. Davidge ST
    (2009) High glucose-induced oxidative stress alters estrogen effects on ERalpha and ERbeta in human endothelial cells:reversal by AMPK activator. J Steroid Biochem Mol Biol 117:99–106.
    OpenUrlCrossRefPubMed
  15. ↵
    1. Wu Y,
    2. Zhang Q,
    3. Zhang R
    (2017) Kaempferol targets estrogen-related receptor ? and suppresses the angiogenesis of human retinal endothelial cells under high glucose conditions. Exp Ther Med 14:5576–5582.
    OpenUrl
  16. ↵
    1. Tennant JR
    (1964) Evaluation of the trypan blue technique for determination of cell viability. Transplantation 2:685–694.
    OpenUrlCrossRefPubMedWeb of Science
  17. ↵
    1. Samaras N,
    2. Papadopoulou MA,
    3. Samaras D,
    4. Ongaro F
    (2014) Off-label use of hormones as an antiaging strategy:a review. Clin Interv Aging 9:1175–1186.
    OpenUrl
  18. ↵
    1. Ota H,
    2. Akishita M,
    3. Akiyoshi T,
    4. Kahyo T,
    5. Setou M,
    6. Sumito O,
    7. et al.
    (2012) Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice:protective role of eNOS and SIRT1. PLos ONE 7:e29598.
    OpenUrlCrossRefPubMedWeb of Science
  19. ↵
    1. Liu L,
    2. Wang D,
    3. Li L,
    4. Ding X,
    5. Ma H
    (2016) Dehydroepiandrosterone inhibits cell proliferation and improves viability by regulating S phase and mitochondrial permeability in primary rat Leydig cells. Mol Med Rep 14:705–714.
    OpenUrl
  20. ↵
    1. Lee MJ,
    2. Kim EH,
    3. Lee SA,
    4. Kang YM,
    5. Jung CH,
    6. Yoon HK,
    7. et al.
    (2015) Dehydroepiandrosterone prevents linoleic acid-induced endothelial cell senescence by increasing autopthagy. Metabolism 64:1134–1145.
    OpenUrl
  21. ↵
    1. Sprando RL,
    2. Collins TF,
    3. Black TN,
    4. Orenjnik N,
    5. Grundel E,
    6. Ruggles DI
    (2004) Effects of androstenedione on in utero development in rats. Food Chem Toxicol 42:917–924.
    OpenUrlCrossRefPubMedWeb of Science
  22. ↵
    1. Hsu SC,
    2. Huang SM,
    3. Lin SH,
    4. Ka SM,
    5. Chen A,
    6. Shin MF,
    7. et al.
    (2014) Testosterone increases renal anti-aging klotho gene expresiion via the androgen receptor-mediated pathway. Biochem J 464:221–229.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    1. Garratt M,
    2. Lagerborg KA,
    3. Tsai YM,
    4. Galecki A,
    5. Jain M,
    6. Miller RA
    (2018) Male lifespan extension with 17-? estradiol is linked to a sex-specific metabolomics response modulated by gonadal hormones in mice. Aging Cell 27:e12786.
    OpenUrl
  24. ↵
    1. Guo JM,
    2. Shu H,
    3. Wang L,
    4. Xu JJ,
    5. Niu XC,
    6. Zhang L
    (2017) SIRT1-dependent AMPK pathway on the protection of estrogen against ischemic brain injury. CNS Neurosci Ther 23:360–369.
    OpenUrl
  25. ↵
    1. Ali ES,
    2. Mangold C,
    3. Peiris AN
    (2017) Estriol:emerging clinical benefits. Menopause 24:1081–1085.
    OpenUrl
  26. ↵
    1. Hamden K,
    2. Carreau S,
    3. Ellouz F,
    4. Masmoudi H,
    5. El FA
    (2007) Protective effect of 17beta-estradiol on oxidative stress and liver dysfunction in aged male rats. J Physiol Biochem 63:195–201.
    OpenUrlCrossRefPubMed
  27. ↵
    1. Burton K,
    2. Shaw L,
    3. Morey LM
    (2015) Differential effect of estradiol and bisphenol A on Set8 and Sirt1 expression in prostate cancer. Toxicol Reo 2:817–823.
    OpenUrl
  28. ↵
    1. Liarte S,
    2. Alonso-Romero JL,
    3. Nicolas FJ
    (2018) SIRT1 signaling cooperation for breast cancer onset and progression. Front Endocrinol (Lausanne) 9:552.
    OpenUrl
  29. ↵
    1. Ahangarpour A,
    2. Najimi SA,
    3. Farbood Y
    (2016) Effects of Vitex agnus-castus fruit on sex hormones and antioxidant indices in a d-galactose-induced aging female mouse model. Chin Med. Assoc 79:589–596.
    OpenUrl
  30. ↵
    1. Kamel NS,
    2. Gammack J,
    3. Cepeda O,
    4. Flaherty JH
    (2006) Antioxidants and hormones as antiaging therapies:high hopes, disappointing results. Cleve Clin J Med 73:1049–1056.
    OpenUrlAbstract/FREE Full Text
  31. ↵
    1. Wang R,
    2. Gao D,
    3. Zhou Y,
    4. Cehn L,
    5. Luo B,
    6. Yu Y,
    7. et al.
    (2017) High glucose impaired estrogen receptor alpha signaling via ß-catenin in osteoblastic MC3T3-E1. J Steroid Biochem Mol Biol 174:276–283.
    OpenUrl
  32. ↵
    1. Kooptiwut S,
    2. Hanchang W,
    3. Semprasert N,
    4. Junking M,
    5. Limjindaporn T,
    6. Yenchitsomanus PT,
    7. et al.
    (2015) Testosterone reduces AGTR1 expression to prevent ß-cell and islet apoptosis from glucotoxicity. J Endocrinol 224:215–224.
    OpenUrlAbstract/FREE Full Text
  33. ↵
    1. Somjen D,
    2. Katzburg S,
    3. Kohen F,
    4. Gayer B,
    5. Sharon O,
    6. Hendel D,
    7. et al.
    (2006) Responsiveness to estradiol-17beta and to phytoestrogens in primary human osteoblasts is modulated differentially by high glucose concentration. J Steroid Biochem Mol Biol 99:139–146.
    OpenUrlPubMed
  34. ↵
    1. Kataoka T,
    2. Hotta Y,
    3. Maeda Y,
    4. Kimura K
    (2014) Assessment of androgen replacement therapy for erectile function in rats with type 2 diabetes mellitus by examining nitric oxide-related and inflammatory factors. J Sex Med 11:920–929.
    OpenUrlPubMed
  35. ↵
    1. Ma S,
    2. Feng J,
    3. Zhang R,
    4. Chen J,
    5. Han D,
    6. Li X,
    7. et al.
    (2017) SIRT1 activation by resveratrol alleviates cardiac dysfunction via mitochondrial regulation in diabetic cardiomyopathy mice. Oxid Med Cell Longev 2017:4602715.
    OpenUrlCrossRef
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