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Research ArticleOriginal Article
Open Access

Predictive value of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in evaluating both lung involvement and severity of patients with coronavirus disease 2019

Yusuf Aksu, Ali U. Uslu, Gülten Tarhan and Mustafa Karagülle
Saudi Medical Journal November 2021, 42 (11) 1223-1228; DOI: https://doi.org/10.15537/smj.2021.42.11.20210485
Yusuf Aksu
From the Department of Radiology (Aksu); and from the Department of Internal Medicine (Uslu, Tarhan, Karagülle), Yunus Emre State Hospital, Eskişehir, Turkey.
MD
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  • For correspondence: [email protected]
Ali U. Uslu
From the Department of Radiology (Aksu); and from the Department of Internal Medicine (Uslu, Tarhan, Karagülle), Yunus Emre State Hospital, Eskişehir, Turkey.
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Gülten Tarhan
From the Department of Radiology (Aksu); and from the Department of Internal Medicine (Uslu, Tarhan, Karagülle), Yunus Emre State Hospital, Eskişehir, Turkey.
PhD, NR
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Mustafa Karagülle
From the Department of Radiology (Aksu); and from the Department of Internal Medicine (Uslu, Tarhan, Karagülle), Yunus Emre State Hospital, Eskişehir, Turkey.
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    Figure 1

    - Receiver-operating characteristic curve of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) for predicting patients with lung involvement of coronavirus disease -19 (COVID-19) in in the study population. AUC: area under the curve, CI: confidence interval

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    Table 1

    - The baseline imaging characteristics of the COVID-19 patients with CT findings (n=131).

    Characteristicsn (%)
    Left upper lobe53 (40.5)
    Left lower lobe108 (82.4)
    Right upper lobe74 (56.5)
    Right middle lobe64 (48.9)
    Right lower lobe101 (77.1)
    Ground glass opasities125 (95.4)
    Consolidation65 (49.6)
    Reticular pattern78 (59.5)
    Crazy paving pattern45 (34.4)
    Lymphadenopathy12 (9.2)
    Pleural efussion5 (3.8)
    Total lung severity score, median (min-max)6.9 (1-18)
    • COVID-19: Coronavirus disease -19, CT: computed tomography

    • View popup
    Table 2

    - Comparison of laboratory features of COVID-19 patients with and without CT findings.

    VariablesCOVID-19 patientsP-value
    With CT findings (n=131)Without CT findings (n=84)
    Mean±SD
    Age, years48.3±15.638.9±15.0<0.0001
    Gender, n (%)   
    Male58 (44.3)44 (52.4)0.247
    Female73 (55.7)40 (47.6) 
    Hemoglobin, g/dL14.06±1.8014.45±1.780.033
    INR1.08±0.171.07±0.100.754
    CRP, mg/L, median (min-max)7.95 (0.60-552.33)3.36 (0.60-40.60)0.010
    Ferritin, median (min-max)89.30 (9.60-851)85.10 (7.80-776.50)0.140
    D-dimer, ng/mL, median (min-max)127 (18-3524)90 (7-2164)0.355
    Platelet, ×109/L218.97±63.61221±58.280.811
    Leucocyte, ×109/L5.97±2.415.77±1.870.508
    Neutrophil, ×109/L3.94±2.413.44±1.670.079
    Lymphocyte, ×109/L1.52±0.701.71±0.590.033
    NLR, median (min-max)2.22 (0.63-25.57)1.88 (0.53-8.61)0.001
    PLR, median (min-max)142.77 (57.94-495.83)130.65 (39.39-325.74)0.005
    • COVID-19: coronavirus disease -19, CT: computed tomography, INR: international normalized ratio, CRP: C-reactive protein, NLR: neutrophil to lymphocyte ratio, PLR: platelet to lymphocyte ratio, SD: standard deviation

    • View popup
    Table 3

    - The correlation between CRP, ferritin and the other markers according to TLSS in patients with COVID-19.

    TLSSrP-value
    Hemoglobin, g/dL0.1530.081
    CRP, mg/L0.599<0.0001
    Ferritin0.3280.008
    Platelet, ×109/L-0.1740.047
    Leucocyte, ×109/L-0.1030.241
    Neutrophil, ×109/L0.0270.756
    Lymphocyte, ×109/L-0.329<0.0001
    D-dimer, ng/mL0.2850.013
    NLR0.2250.010
    PLR0.2440.005
    • CRP: C-reactive protein, COVID-19: coronavirus disease -19, TLSS: total lung severity score, NLR: neutrophil to lymphcyte ratio, PLR: platelet to lymphocyte ratio

    • View popup
    Table 4

    - Linear regression analysis for TLSS in patients with coronavirus disease -19 (COVID-19).

    Independent variablesBeta regression coefficientP-value
    BUN-0.0580.300
    Creatinine0.0440.552
    ALT-01900.243
    AST0.3950.073
    LDH0.8950.035
    INR0.1820.151
    CRP1.8390.019
    Ferritin-1.7380.019
    Platelet-2.9990.041
    Leucocyte-0.8410.454
    Neutrophil4.0770.084
    Lymphocyte-0.3800.379
    NLR4.3700.036
    PLR-4.1610.024
    • TLSS: total lung severity score, BUN: blood urea nitrogen, ALT: alanine transaminase, AST: aspartate transaminase, LDH: lactate dehydrogenase, INR: international normalized ratio, CRP: C-reactive protein, NLR: neutrophil to lymphocyte ratio, PLR: platelet to lymphocyte ratio

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Predictive value of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in evaluating both lung involvement and severity of patients with coronavirus disease 2019
Yusuf Aksu, Ali U. Uslu, Gülten Tarhan, Mustafa Karagülle
Saudi Medical Journal Nov 2021, 42 (11) 1223-1228; DOI: 10.15537/smj.2021.42.11.20210485

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Predictive value of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in evaluating both lung involvement and severity of patients with coronavirus disease 2019
Yusuf Aksu, Ali U. Uslu, Gülten Tarhan, Mustafa Karagülle
Saudi Medical Journal Nov 2021, 42 (11) 1223-1228; DOI: 10.15537/smj.2021.42.11.20210485
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Keywords

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  • COVID-19 pneumonia

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