Article Figures & Data
Figures
- Figure 1
- Sheep liver harvesting. A) The aorta and inferior vena cava (IVC) exposed for cannulation. B) The aorta at the hiatus of the diaphragm exposed for clamping just prior to organ flushing in preparation for retrieval. C) Anatomy of the liver hilum in the sheep; the hepatic artery (HA) encircled with the portal vein (PV), and the common bile duct (BD) posteriorly and laterally.
- Figure 2
- Normothermic oxygenated machine perfusion circuit. A) A schematic representation. B) Components of the normothermic machine perfusion system.
- Figure 3
- Hemodynamics in the sheep liver showing a steady state over 3 hours with a portal pressure average of 16-19 mmHg and volume up to 450 ml/min. The hepatic artery (HA) pressure average is around 50 mmHg with a volume of 120-200 ml/min. PV: portal vein
- Figure 4
- Hemodynamics in the sheep liver showing a steady state over 9 hours with a portal pressure average of 17-20 mmHg and volume up to 1400 ml/min. The hepatic artery (HA) pressure average is around 50 mmHg with a volume of 300 ml/min. PV: portal vein
- Figure 5
- Sheep liver with a cannulated hepatic artery (HA), portal vein (PV), and inferior vena cava (IVC). A) Perfused with normothermic oxygenated albumin-based fluid with packed red blood cells. B) Steen solution with resulting bile duct (BD) production.
Tables
- Table 1
- Studies on isolated porcine liver normothermic perfusion utilizing arterial pressure circuit control.8,9
Author PV HA Perfusion period Butler, 2002 7.22 mmHg 90.3 mmHg 72 h 1.75 L/min 240 ml/min Schön, 2001 11 mmHg 100 mmHg 4 h 250 ml/min 150 ml/min St Peter, 2003 8 mmHg 60-120 mmHg 3 h 0.42 L/min 0.18 L/min Jakob, 1990 5-15 mmHg 70-105 mmHg 24 h 0.75 L/min 0.25 L/min Ghonem, 2011 18 mmHg 100-130 mmHg 3.5 h 350-475 ml/min 150-220 ml/min Echeverri, 2018 2-4 mmHg 60 mmHg 900-1200 ml/min 400 ml/min Boehnert, 2013 10 cm H2O 60 mmHg 12 h 950±110 ml/min 365±85 ml/min Banan, 2015 12±4 mmHg 85±10 mmHg 2 h 1.2±0.2 L/min 0.5±0.1 L/min He X, 2018 8-10 mmHg 80-100 mmHg 310-590 ml/min 110-240 ml/min PV: portal vein, HA: hepatic artery, h: hours, min: minute, L: liter, ml: milliliter, mmHg: millimeter mercuryn h: hours
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