Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats: Impact on therapeutics

Ali M. Alshabi; Saad A. Alkahtani; Ibrahim A. Shaikh; Mohammed S. Habeeb

doi:10.15537/smj.2021.2.25695

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Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats

Impact on therapeutics

Ali M. Alshabi, Saad A. Alkahtani, Ibrahim A. Shaikh and Mohammed S. Habeeb

Saudi Medical Journal February 2021, 42 (2) 151-160; DOI: https://doi.org/10.15537/smj.2021.2.25695

Ali M. Alshabi

From the Department of Clinical Pharmacy (Alshabi, Alkahtani), and from the Department of Pharmacology (Shaikh, Habeeb), College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia.

M.Pharm, PhD

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For correspondence: [email protected]

Saad A. Alkahtani

From the Department of Clinical Pharmacy (Alshabi, Alkahtani), and from the Department of Pharmacology (Shaikh, Habeeb), College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia.

M.Pharm, PhD

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Ibrahim A. Shaikh

From the Department of Clinical Pharmacy (Alshabi, Alkahtani), and from the Department of Pharmacology (Shaikh, Habeeb), College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia.

M.Pharm

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Mohammed S. Habeeb

From the Department of Clinical Pharmacy (Alshabi, Alkahtani), and from the Department of Pharmacology (Shaikh, Habeeb), College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia.

M.Pharm

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vol. 42 no. 2 151-160

DOI

https://doi.org/10.15537/smj.2021.2.25695

PubMed

33563733

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Saudi Medical Journal

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1658-3175

History

Received December 18, 2020
Accepted January 6, 2021
Published online February 9, 2021.

Copyright: © Saudi Medical Journal This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Information

Ali M. Alshabi, M.Pharm, PhD ⇑,
Saad A. Alkahtani, M.Pharm, PhD,
Ibrahim A. Shaikh, M.Pharm and
Mohammed S. Habeeb, M.Pharm

From the Department of Clinical Pharmacy (Alshabi, Alkahtani), and from the Department of Pharmacology (Shaikh, Habeeb), College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia.

Address correspondence and reprint request to: Dr. Ali M. Alshabi, Vice Dean, Academic Affairs, Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia. E-mail: dr.aliresearch19{at}gmail.com ORCID ID: https://orcid.org/0000-0002-9346-2559

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Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats

Ali M. Alshabi, Saad A. Alkahtani, Ibrahim A. Shaikh, Mohammed S. Habeeb

Saudi Medical Journal Feb 2021, 42 (2) 151-160; DOI: 10.15537/smj.2021.2.25695

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Caffeine modulates pharmacokinetic and pharmacodynamic profiles of pioglitazone in diabetic rats

Ali M. Alshabi, Saad A. Alkahtani, Ibrahim A. Shaikh, Mohammed S. Habeeb

Saudi Medical Journal Feb 2021, 42 (2) 151-160; DOI: 10.15537/smj.2021.2.25695

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Keywords

caffeine
pioglitazone
antidiabetic
pharmacokinetic
pharmacodynamic

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Impact on therapeutics

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