Article Figures & Data
Figures
- Figure 1
- The differences in histological subtypes between the younger and older patients (p=0.174). IDC: invasive ductal carcinoma, ILC: invasive lobular carcinoma, DCIS: ductal carcinoma in situ, LCIS: lobular carcinoma in situ
Tables
- Table 1
- Comparison of clinicopathological features between the young and old patients (≤40 years and >40 years of age) at diagnosis.
Variables Group 1 (≤40 years) n (%) Group 2 (>40 years) n (%) P-value Tumor type 0.174 Invasive ductal 153 (88.5) 458 (85.6) Invasive lobular 2 (1.1) 33 (6.2) Ductal carcinoma in situ 13 (7.5) 27 (5) Lobular carcinoma in situ - 2 (0.4) Other 5 (2.9) 15 (2.8) Tumor size 0.046 ≤2 cm 23 (16.2) 85 (26.6) >2 cm - ≤5cm 80 (56.3) 162 (50.8) >5 cm 39 (27.5) 72 (22.6) Histological grading <0.0001 Grade I 13 (8.6) 51 (11.2) Grade II 55 (36.2) 242 (53.5) Grade III 84 (55.2) 160 (35.3) TNM staging 0.047 Stage 0 13 (7.7) 27 (7.2) Stage I 58 (34.3) 166 (44.4) Stage II 45 (26.6) 102 (27.3) Stage III 53 (31.4) 79 (21.1) Axillary lymph node metastasis 0.606 No 81 (60.9) 183 (58.3) Yes 52 (39.1) 131 (41.7) Number of axillary lymph node metastasis 0.129 0 81 (60.9) 183 (58.3) 1-3 14 (10.5) 45 (14.4) 4-9 25 (18.8) 39 (12.4) ≥10 13 (9.8) 47 (14.9) Lymphovascular invasion <0.0001 No 49 (32.5) 254 (62.6) Yes 102 (67.5) 152 (37.4) Distant metastases <0.0001 No 51 (35.7) 285 (68.2) Yes 92 (64.3) 133 (31.8) Locoregional recurrence 0.163 No 73 (66.4) 159 (58.7) Yes 37 (33.6) 112 (41.3) Type of surgery 0.150 Breast conserving surgery 19 (66.4) 88 (58.7) Mastectomy 117 (33.6) 366 (41.3) Estrogen receptor (ER) status 0.0001 Negative 74 (51.7) 145 (34.1) Positive 69 (48.3) 280 (65.9) Progesterone receptor (PR) status <0.0001 Negative 87 (56.9) 148 (32.9) Positive 66 (43.1) 301 (67.1) Her2neu status 0.002 Negative 84 (55.3) 294 (69) Positive 68 (44.7) 132 (31) Tumor subtype <0.0001 Luminal A 32 (21.5) 163 (43.1) Luminal B 28 (18.8) 75 (19.8) Triple negative 41 (27.5) 50 (13.2) HER2-postive 48 (32.2) 90 (23.8) In situ component 0.441 Negative 87 (61.7) 163 (57.8) Positive 54 (38.3) 119 (42.2) Ki67 expression 0.082 Negative 71 (53.4) 219 (62) Positive 62 (46.6) 134 (38) - Table 2
- Sub analysis of estrogen receptor (ER) positive tumors with respect to age, tumor size, tumor grade, lymphovascular invasion, lymph node metastasis, distant metastasis and Ki67 expression.
Variables ≤40 with ER+ve (n=69) >40 with ER+ve (n=280) P-value Tumor size 0.473 ≤2 cm 10 (14.5) 57 (20.4) >2 cm - ≤5 cm 47 (68.1) 184 (65.7) > 5cm 12 (17.4) 39 (13.9) Histological grading 0.0001 Grade I 4 (5.8) 25 (8.9) Grade II 32 (46.4) 192 (68.6) Grade III 33 (47.8) 63 (22.5) Axillary lymph node metastasis <0.0001 No 17 (24.6) 187 (66.8) Yes 52 (75.4) 93 (33.2) Lymphovascular invasion 0.003 No 11 (15.9) 96 (34.3) Yes 58 (84.1) 184 (65.7) Distant metastases 0.0008 No 13 (52.0) 113 (57.3) Yes 56 (48.0) 167 (42.7) Ki67 expression 0.455 Negative 34 (49.3) 124 (44.3) Positive 35 (50.7) 156 (55.7) Values are expressed as number and percentage (%)
- Table 3
- Sub analysis of estrogen receptor (ER) negative tumors with respect to age, tumor size, tumor grade, lymphovascular invasion, lymph node metastasis, distant metastasis and Ki67 expression.
Variables ≤40 with ER-ve (n=74) >40 with ER-ve (n=145) P value Tumor size 0.413 ≤2 cm 12 (16.2) 31 (21.4) >2 cm - ≤5 cm 55 (74.3) 95 (65.5) >5 cm 7 (9.5) 19 (13.1) Histological grading 0.341 Grade I 3 (4.0) 4 (2.7) Grade II 19 (25.7) 51 (35.2) Grade III 52 (70.3) 90 (62.1) Axillary lymph node metastasis 0.021 No 18 (24.3) 57 (39.3) Yes 56 (75.7) 87 (60.7) Lymphovascular invasion 0.575 No 12 (16.2) 28 (19.3) Yes 62 (83.8) 117 (80.7) Distant metastases 0.890 No 19 (25.7) 36 (24.8) Yes 55 (74.3) 109 (75.2) Ki67 expression <0.0001 Negative 0 (0) 37 (25.5) Positive 74 (100) 108 (74.5) Values are expressed as number and percentage (%)
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