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Research ArticleOriginal Article
Open Access

Clinicopathological characteristics of young versus older patients with breast cancer

A retrospective comparative study from the Madinah region of Saudi Arabia

Abdulkader M. Albasri
Saudi Medical Journal July 2021, 42 (7) 769-775; DOI: https://doi.org/10.15537/smj.2021.42.7.20200750
Abdulkader M. Albasri
From the Department of Pathology, Taibah University, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia.
MBBCh, PhD
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References

  1. 1.↵
    World Health Organization. Global Health Estimates 2020: Deaths by cause, age, sex, by country and by region, 2000-2019. [Update 2020; Accessed 2020 December 11]. Available from: https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-leading-causes-of-death
  2. 2.↵
    1. Sung H,
    2. Ferlay J,
    3. Siegel RL,
    4. Laversanne M,
    5. Soerjomataram I,
    6. Jemal A,
    7. Bray F.
    Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 0; 1–41.
    OpenUrl
  3. 3.↵
    Saudi Heath Council. Cancer Incidence Report, Saudi Arabia 2016. Saudi Cancer Registry. Riyadh (KSA): National Health Information Center; July 2019.
  4. 4.↵
    1. Anders CK,
    2. Johnson R,
    3. Litton, J,
    4. Phillips M,
    5. Bleyer A.
    Breast cancer before age 40 years. Semin Oncol 2009; 36: 237–249.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.
    1. Bodmer A,
    2. Feller A,
    3. Bordoni A,
    4. Bouchardy C,
    5. Dehler S,
    6. Ess S, et al.
    Breast cancer in younger women in Switzerland 1996-2009: A longitudinal population-based study. Breast 2015; 24: 112–117.
    OpenUrl
  6. 6.
    1. Brenner DR,
    2. Brockton NT,
    3. Kotsopoulos J,
    4. Cotterchio M,
    5. Boucher BA,
    6. Kerry S, et al.
    Breast cancer survival among young women: a review of the role of modifiable lifestyle factors. Cancer Causes Control 2016; 27: 459–472.
    OpenUrl
  7. 7.↵
    Canadian Cancer Society’s Advisory Committee on Cancer Statistics. Canadian Cancer Statistics 2015. Toronto (ON): Canadian Cancer Society; 2015.
  8. 8.↵
    1. Ntekim NA,
    2. Nufu FT,
    3. Campbell OB.
    Breast cancer in young women in Ibadan, Nigeria. Afr Health Sci 2009; 9: 242–246.
    OpenUrlPubMed
  9. 9.↵
    1. Shitalmala T,
    2. Rajesh SL,
    3. Kaushik D.
    Breast carcinoma in young females below the age of 40 years: A histopathological perspective. South Asian J Cancer 2014; 3: 97–100.
    OpenUrl
  10. 10.↵
    1. Foo CS,
    2. Su D,
    3. Chong CK, et al.
    Breast cancer in young Asian women: Study on survival. ANZ Journal of Surgery 2005; 75: 566–572.
    OpenUrlCrossRefPubMedWeb of Science
  11. 11.↵
    1. Telfah, A,
    2. Obeidat M,
    3. Swailmeen A, et al.
    Breast Cancers in Young Women: A Retrospective Study at King Hussein Medical Center. Journal of the Royal Medical Services 2015; 22: 62–68.
    OpenUrl
  12. 12.↵
    1. Maggard MA,
    2. O’Connel JB,
    3. Lane KE, et al.
    Do young breast cancer patients have worse outcomes? J Surg Res 2003; 113: 109–113.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Bharat A,
    2. Aft RL,
    3. Gao F,
    4. Margenthaler JA.
    Patient and tumor characteristics associated with increased mortality in young women (<40 years) with breast cancer. J Surg Oncol 2009; 100: 248–251.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Cancello G,
    2. Maisonneuve P,
    3. Rotmensz N,
    4. Viale G,
    5. Mastropasqua MG,
    6. Pruneri G, et al.
    Prognosis and adjuvant treatment effects in selected breast cancer subtypes of very young women (<35 years) with operable breast cancer. Ann Oncol 2010; 21: 1974–1981.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Tan P,
    2. Ellis I,
    3. Kimberly A,
    4. Edi B,
    5. Stephen F,
    6. Lakhani S, et al.
    The 2019 WHO classification of tumours of the breast. Histopathology 2020; 77: 181–185.
    OpenUrl
  16. 16.↵
    1. Goldhirsch A,
    2. Ingle JN,
    3. Gelber RD,
    4. Coates AS,
    5. Thürlimann B,
    6. Senn HJ.
    Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Ann Oncol 2009; 20: 1319–1329.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Dai X,
    2. Xiang L,
    3. Li T,
    4. Bai Z.
    Cancer hallmarks, biomarkers and breast cancer molecular subtypes. J Cancer 2016; 7: 1281–1294.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Wang K,
    2. Ren Y,
    3. Li H,
    4. Zheng K,
    5. Jiang J,
    6. Zou T, et al.
    Comparison of clinicopathological features and treatments between young (≤40 Years) and older (>40 years) female breast cancer patients in west China: A retrospective, epidemiological, multicenter, case only study. PLoS One 2016; 11: e0152312.
    OpenUrl
  19. 19.↵
    1. Vostakolaei FA,
    2. Broeders MM,
    3. Rostami N,
    4. van Dijck JAM,
    5. Feuth T,
    6. Kiemeney LLM, et al.
    Age at diagnosis and breast cancer survival in Iran. Int J Breast Cancer 2012; 2012: 517976.
    OpenUrl
  20. 20.↵
    1. Zeeshan S,
    2. Ali B,
    3. Ahmad K,
    4. Chagpar AB,
    5. Sattar AK.
    Clinicopathological features of young versus older patients with breast cancer at a single Pakistani Institution and a comparison with a National US Database. J Glob Oncol 2019; 5: 1–6.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Al-Shamsi HO,
    2. Alrawi S.
    Breast cancer screening in the United Arab Emirates: is it time to call for a screening at an earlier age? J Cancer Prev Curr Res 2018; 9: 123–126.
    OpenUrl
  22. 22.↵
    1. Rudat V,
    2. El-Sweilmeen H,
    3. Fadel E,
    4. Brune-Erber I,
    5. Nour AA,
    6. Bushnag Z, et al.
    Age of 40 years or younger is an independent risk factor for locoregional failure in early breast cancer: A single-institutional analysis in Saudi Arabia. J Oncol 2012; 2012: 370385.
    OpenUrlPubMed
  23. 23.↵
    1. Nuzhat, A,
    2. Abouzaid L.
    Female breast cancer in different age groups: clincopathological features and treatment strategies. International Journal of Community Medicine and Public Health 2017; 4: 1399.
    OpenUrl
  24. 24.↵
    1. Elkum N,
    2. Dermime S,
    3. Ajarim D,
    4. Al-Zahrani A,
    5. Alsayed A,
    6. Tulbah A, et al.
    Being 40 or younger is an independent risk factor for relapse in operable breast cancer patients: the Saudi Arabia experience. BMC Cancer 2007; 5: 222.
    OpenUrl
  25. 25.↵
    1. Pathy NB,
    2. Yip CH,
    3. Taib NA,
    4. Hartman M,
    5. Saxena N,
    6. Iau P, et al.
    Breast cancer in a multi-ethnic Asian setting: results from the Singapore-Malaysia hospital-based breast cancer registry. Breast 2011; 20: S75–S80.
    OpenUrl
  26. 26.
    1. Kwong A,
    2. Mang OWK,
    3. Wong CHN,
    4. Chau WW,
    5. Law SCK.
    Breast cancer in Hong Kong, Southern China: the first population-based analysis of epidemiological characteristics, stage-specific, cancer-specific, and disease-free survival in breast cancer patients: 1997-2001. Ann Surg Oncol 2011; 18: 3072–3078.
    OpenUrlPubMed
  27. 27.↵
    1. Raina V,
    2. Bhutani M,
    3. Bedi R,
    4. Sharma A,
    5. Deo SV,
    6. Shukla NK, et al.
    Clinical features and prognostic factors of early breast cancer at a major cancer center in North India. Indian J Cancer 2005; 42: 40–45.
    OpenUrlPubMed
  28. 28.↵
    General Authority for Statistics. Demographi Survey. [Online] [Updated 2016; Accessed 2020 August 8]. Available from: https://www.stats.gov.sa/sites/default/files/en-demographic-research-2016_2.pdf.
  29. 29.↵
    Statista. Resident population of the United States by sex and age as of July 1, 2019. [Updated 2021; Accessed 2020 October 1]. Available from: https://www.statista.com/statistics/241488/population-of-the-us-by-sex-and-age/
  30. 30.↵
    1. Anders CK,
    2. Hsu DS,
    3. Broadwater G,
    4. Acharya CR,
    5. Foekens JA,
    6. Zhang Y, et al.
    Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol 2008; 26: 3324–3330.
    OpenUrlAbstract/FREE Full Text
  31. 31.↵
    1. Zhang X,
    2. Yang J,
    3. Cai H,
    4. Ye Y.
    Young age is an independent adverse prognostic factor in early stage breast cancer: a population based study. Cancer Manag Res 2018; 27: 4005–4018.
    OpenUrl
  32. 32.↵
    1. Azim HA Jr.,
    2. Michiels S,
    3. Bedard PL,
    4. Singhal SK,
    5. Criscitiello C,
    6. Ignatiadis M, et al.
    Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling. Clin Cancer Res 2012; 18: 1341–1351.
    OpenUrlAbstract/FREE Full Text
  33. 33.↵
    1. Aine M,
    2. Boyaci C,
    3. Hartman J,
    4. Häkkinen J,
    5. Mitra S,
    6. Campos AB, et al.
    Molecular analyses of triple-negative breast cancer in the young and elderly. Breast Cancer Res 2021; 23: 20.
    OpenUrl
  34. 34.↵
    1. Ma D,
    2. Jiang YZ,
    3. Xiao Y,
    4. Xie MD,
    5. Zhao S,
    6. Jin X,
    7. Xu XE,
    8. Shao ZM.
    Integrated molecular profiling of young and elderly patients with triple-negative breast cancer indicates different biological bases and clinical management strategies. Cancer 2020; 126: 3209–3218.
    OpenUrl
  35. 35.↵
    1. Al-Thoubaity FK.
    Molecular classification of breast cancer: A retrospective cohort study. Ann Med Surg (Lond) 2019; 49: 44–48.
    OpenUrl
  36. 36.↵
    1. Radosa JC,
    2. Eaton A,
    3. Stempel M,
    4. Khander A,
    5. Liedtke C,
    6. Solomayer EF, et al.
    Evaluation of Local and Distant Recurrence Patterns in Patients with Triple-Negative Breast Cancer According to Age. Ann Surg Oncol 2017; 24: 698–704.
    OpenUrlCrossRefPubMed
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Clinicopathological characteristics of young versus older patients with breast cancer
Abdulkader M. Albasri
Saudi Medical Journal Jul 2021, 42 (7) 769-775; DOI: 10.15537/smj.2021.42.7.20200750

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Clinicopathological characteristics of young versus older patients with breast cancer
Abdulkader M. Albasri
Saudi Medical Journal Jul 2021, 42 (7) 769-775; DOI: 10.15537/smj.2021.42.7.20200750
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