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Research ArticleOriginal Article
Open Access

Analgesic effect of dexmedetomidine in colorectal cancer patients undergoing laparoscopic surgery

Ja E. Lee, Hue J. Park, Yoon J. Chung, Hyun J. Ahn, Woo S. Sim and Jin Y. Lee
Saudi Medical Journal October 2022, 43 (10) 1096-1102; DOI: https://doi.org/10.15537/smj.2022.43.10.20220526
Ja E. Lee
From the Department of Anesthesiology and Pain Medicine (JE. Lee, Chung, Ahn, Sim, JY. Lee), Samsung Medical Center, School of Medicine, Sungkyunkwan University, and from the Department of Anesthesiology and Pain Medicine (Park), Seoul St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
MD
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Hue J. Park
From the Department of Anesthesiology and Pain Medicine (JE. Lee, Chung, Ahn, Sim, JY. Lee), Samsung Medical Center, School of Medicine, Sungkyunkwan University, and from the Department of Anesthesiology and Pain Medicine (Park), Seoul St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
MD, PhD
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Yoon J. Chung
From the Department of Anesthesiology and Pain Medicine (JE. Lee, Chung, Ahn, Sim, JY. Lee), Samsung Medical Center, School of Medicine, Sungkyunkwan University, and from the Department of Anesthesiology and Pain Medicine (Park), Seoul St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
MD
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Hyun J. Ahn
From the Department of Anesthesiology and Pain Medicine (JE. Lee, Chung, Ahn, Sim, JY. Lee), Samsung Medical Center, School of Medicine, Sungkyunkwan University, and from the Department of Anesthesiology and Pain Medicine (Park), Seoul St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
MD, PhD
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Woo S. Sim
From the Department of Anesthesiology and Pain Medicine (JE. Lee, Chung, Ahn, Sim, JY. Lee), Samsung Medical Center, School of Medicine, Sungkyunkwan University, and from the Department of Anesthesiology and Pain Medicine (Park), Seoul St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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Jin Y. Lee
From the Department of Anesthesiology and Pain Medicine (JE. Lee, Chung, Ahn, Sim, JY. Lee), Samsung Medical Center, School of Medicine, Sungkyunkwan University, and from the Department of Anesthesiology and Pain Medicine (Park), Seoul St. Mary’s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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  • For correspondence: [email protected]
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References

  1. 1.↵
    1. Thapa P,
    2. Euasobhon P.
    Chronic postsurgical pain: current evidence for prevention and management. Korean J Pain 2018; 31: 155–173.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Glare P,
    2. Aubrey KR,
    3. Myles PS.
    Transition from acute to chronic pain after surgery. Lancet 2019; 393: 1537–1546.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Gan TJ.
    Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res 2017; 10: 2287–2298.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Özdilek A,
    2. Beyoğlu ÇA,
    3. Demirdağ Ç,
    4. Şen Ö,
    5. Erbabacan ŞE,
    6. Ekici B, et al.
    Perioperative analgesic effects of preemptive ultrasound-guided subcostal transversus abdominis plane block for percutaneous nephrolithotomy: a prospective, randomized trial. J Endourol 2020; 34: 434–440.
    OpenUrl
  5. 5.↵
    1. Wick EC,
    2. Grant MC,
    3. Wu CL.
    Postoperative multimodal analgesia pain management with nonopioid analgesics and techniques: a review. JAMA Surg 2017; 152: 691–697.
    OpenUrl
  6. 6.↵
    1. Boretsky K,
    2. Mason K.
    In the arms of Morpheus without morphia; mitigating the United States opioid epidemic by decreasing the surgical use of opioids. J Clin Med 2021; 10: 1472.
    OpenUrl
  7. 7.↵
    1. Chen Q,
    2. Chen E,
    3. Qian X.
    A narrative review on perioperative pain management strategies in enhanced recovery pathways-the past, present, and future. J Clin Med 2021; 10: 2568.
    OpenUrl
  8. 8.↵
    1. Kehlet H.
    Postoperative pain, analgesia, and recovery-bedfellows that cannot be ignored. Pain 2018; 159: S11–S16.
    OpenUrl
  9. 9.↵
    1. Lee S.
    Dexmedetomidine: present and future directions. Korean J Anesthesiol 2019; 72: 323–330.
    OpenUrl
  10. 10.↵
    1. Ahuja V,
    2. Thapa D,
    3. Chander A,
    4. Gombar S,
    5. Gupta R,
    6. Gupta S.
    Role of dexmedetomidine as adjuvant in postoperative sciatic popliteal and adductor canal analgesia in trauma patients: a randomized controlled trial. Korean J Pain 2020; 33: 166–175.
    OpenUrlPubMed
  11. 11.↵
    1. Zhao Y,
    2. He J,
    3. Yu N,
    4. Jia C,
    5. Wang S.
    Mechanisms of dexmedetomidine in neuropathic pain. Front Neurosci 2020; 14: 330.
    OpenUrl
  12. 12.↵
    1. Kaye AD,
    2. Chernobylsky DJ,
    3. Thakur P,
    4. Siddaiah H,
    5. Kaye RJ,
    6. Eng LK, et al.
    Dexmedetomidine in enhanced recovery after surgery (ERAS) protocols for postoperative pain. Curr Pain Headache Rep 2020; 24: 21.
    OpenUrl
  13. 13.↵
    1. Choi JJ,
    2. Kim K,
    3. Park HY,
    4. Chang YJ,
    5. Lee KC,
    6. Kim KY, et al.
    CONSORT the effect of a bolus dose of dexmedetomidine on postoperative pain, agitation, and quality of recovery after laparoscopic cholecystectomy. Medicine (Baltimore) 2021; 100: e24353.
    OpenUrl
  14. 14.↵
    1. Wang J,
    2. Xie WP,
    3. Lei YQ,
    4. Wang ZC,
    5. Cao H,
    6. Chen Q.
    Clinical effect of dexmedetomidine combined with sufentanil on postoperative analgesia for transthoracic device closure of ventricular septal defects in children with ultrafast track anesthesia. J Cardiothorac Surg 2021; 16: 206.
    OpenUrl
  15. 15.
    1. Naduvanahalli Vivekanandaswamy A,
    2. Prasad Shetty A,
    3. Mugesh Kanna R,
    4. Shanmuganathan R.
    An analysis of the safety and efficacy of dexmedetomidine in posterior spinal fusion surgery for adolescent idiopathic scoliosis: a prospective randomized study. Eur Spine J 2021; 30: 698–705.
    OpenUrl
  16. 16.
    1. Long JB,
    2. Bevil K,
    3. Giles DL.
    Preemptive analgesia in minimally invasive gynecologic surgery. J Minim Invasive Gynecol 2019; 26: 198–218.
    OpenUrl
  17. 17.↵
    1. Azemati S,
    2. Pourali A,
    3. Aghazadeh S.
    Effects of adding dexmedetomidine to local infiltration of bupivacaine on postoperative pain in pediatric herniorrhaphy: a randomized clinical trial. Korean J Anesthesiol 2020; 73: 212–218.
    OpenUrl
  18. 18.↵
    1. Lee J,
    2. Hwang HW,
    3. Jeong JY,
    4. Kim YM,
    5. Park C,
    6. Kim JY.
    The effect of low-dose dexmedetomidine on pain and inflammation in patients undergoing laparoscopic hysterectomy. J Clin Med 2022; 11: 2802.
    OpenUrl
  19. 19.↵
    1. Ni X,
    2. Jia D,
    3. Chen Y,
    4. Wang L,
    5. Suo J.
    Is the enhanced recovery after surgery (ERAS) program effective and safe in laparoscopic colorectal cancer surgery? A meta-analysis of randomized controlled trials. J Gastrointest Surg 2019; 23: 1502–1512.
    OpenUrl
  20. 20.↵
    1. Gustafsson UO,
    2. Scott MJ,
    3. Hubner M,
    4. Nygren J,
    5. Demartines N,
    6. Francis N, et al.
    Guidelines for perioperative care in elective colorectal surgery: enhanced recovery after surgery (ERAS®) society recommendations: 2018. World J Surg 2019; 43: 659–695.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Kwon JH,
    2. Park HJ,
    3. Sim WS,
    4. Park JH,
    5. Jung KH,
    6. Oh MS, et al.
    Evaluation of the intraoperative perfusion index for correlation with acute postoperative pain in patients undergoing laparoscopic colorectal cancer surgery. J Clin Med 2019; 8: 1299.
    OpenUrl
  22. 22.↵
    1. Lee JY,
    2. Kim HC,
    3. Huh JW,
    4. Sim WS,
    5. Lim HY,
    6. Lee EK, et al.
    Incidence and risk factors for rectal pain after laparoscopic rectal cancer surgery. J Int Med Res 2017; 45: 781–791.
    OpenUrl
  23. 23.↵
    1. Su P,
    2. Li Z,
    3. Jia X,
    4. Peng X,
    5. Liu D,
    6. Xiao J, et al.
    A response surface analysis of the combination of dexmedetomidine and sufentanil for attenuating the haemodynamic response to endotracheal intubation. Dose Response 2022; 20: 15593258221092367.
    OpenUrl
  24. 24.↵
    1. Yang SY,
    2. Kim HS,
    3. Cho MS,
    4. Kim NK.
    Three-dimensional anatomy of the Denonvilliers’ fascia after micro-CT reconstruction. Sci Rep 2021; 11: 21759.
    OpenUrl
  25. 25.↵
    1. Grass F,
    2. Cachemaille M,
    3. Martin D,
    4. Fournier N,
    5. Hahnloser D,
    6. Blanc C, et al.
    Pain perception after colorectal surgery: a propensity score matched prospective cohort study. Biosci Trends 2018; 12: 47–53.
    OpenUrl
  26. 26.↵
    1. Kang SH,
    2. Sim WS,
    3. Park HJ,
    4. Moon JY,
    5. Seon HJ,
    6. Lee JY.
    Efficacy of adjuvant dexmedetomidine in supraclavicular brachial plexus block for intractable complex regional pain syndrome: a case report with a 3-year follow-up. J Clin Pharm Ther 2020; 45: 365–367.
    OpenUrl
  27. 27.↵
    1. Wang K,
    2. Li C.
    Effects of dexmedetomidine on inflammatory factors, T lymphocyte subsets and expression of NF-κB in peripheral blood mononuclear cells in patients receiving radical surgery of colon carcinoma. Oncol Lett 2018; 15: 7153–7157.
    OpenUrl
  28. 28.↵
    1. Chilkoti GT,
    2. Kumar M,
    3. Mohta M,
    4. Saxena AK,
    5. Sharma N,
    6. Singh J.
    Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: a randomised, controlled trial. Indian J Anaesth 2019; 63: 106–113.
    OpenUrl
  29. 29.↵
    1. Zhang Z,
    2. Hao D.
    Optimal dose of dexmedetomidine for preemptive analgesia combined with transversus abdominis plane block after colon cancer surgery. J Nippon Med Sch 2022; 89: 399–404.
    OpenUrl
  30. 30.↵
    1. Zhao L,
    2. Li Y.
    Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients. Oncol Lett 2020; 20: 1288–1294.
    OpenUrl
  31. 31.↵
    1. Bellon M,
    2. Le Bot A,
    3. Michelet D,
    4. Hilly J,
    5. Maesani M,
    6. Brasher C, et al.
    Efficacy of intraoperative dexmedetomidine compared with placebo for postoperative pain management: a meta-analysis of published studies. Pain Ther 2016; 5: 63–80.
    OpenUrl
  32. 32.↵
    1. Fan W,
    2. Yang H,
    3. Sun Y,
    4. Zhang J,
    5. Li G,
    6. Zheng Y, et al.
    Comparison of the pro-postoperative analgesia of intraoperative dexmedetomidine with and without loading dose following general anesthesia: a prospective, randomized, and controlled clinical trial. Medicine (Baltimore) 2017; 96: e6106.
    OpenUrl
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Analgesic effect of dexmedetomidine in colorectal cancer patients undergoing laparoscopic surgery
Ja E. Lee, Hue J. Park, Yoon J. Chung, Hyun J. Ahn, Woo S. Sim, Jin Y. Lee
Saudi Medical Journal Oct 2022, 43 (10) 1096-1102; DOI: 10.15537/smj.2022.43.10.20220526

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Analgesic effect of dexmedetomidine in colorectal cancer patients undergoing laparoscopic surgery
Ja E. Lee, Hue J. Park, Yoon J. Chung, Hyun J. Ahn, Woo S. Sim, Jin Y. Lee
Saudi Medical Journal Oct 2022, 43 (10) 1096-1102; DOI: 10.15537/smj.2022.43.10.20220526
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  • colon
  • dexmedetomidine
  • pain
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