Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus

Article Figures & Data

Table 1

- Anthropometric and biochemical characteristics of study groups.

Parameter	Patient group	Control group	P-value
Mean age: year	53.19 (10.96)	51.34 (13.78)	0.002
Gender n(%)
Female	55 (46.6)	48 (45.3)
Male	63 (53.4)	58 (54.7)
FBG	8.4 (3.5)	5.41 (1.1)	<0.001
HbA1c	8.69 (3.0)	5.32 (0.6)	<0.001
BMI	30.68 (6.3)	25.90 (3.4)	<0.001

Values are presented as numbers and percentages (%). FBG: fasting blood glucose, HbA1c: hemoglobin A1c, BMI: body mass index

Table 2

- Fat mass and obesity-associated rs8050136 single nucleotide polymorphism genotypes and variant allele frequencies among study groups.

Genotype	Patients	Controls	Odd ratio (95% CI)	P-value
CC	23 (19.5)	26 (24.5)	1	0.54
CA	74 (62.7)	59 (55.7)	1.42 (0.73-2.74)
AA	21 (17.8)	21 (19.8)	1.13 (0.50-2.58)
Allele C	120 (50.8)	111 (52.4)		0.75
Allele A	116 (49.2)	101 (47.6)		0.75

Table 3

- The relationships between the FTO rs8050136 SNPs and FBG, HbA1c, and BMI among study groups.

Parameter/genotype	AA	AC	CC	F value	P-value
Control group	21	59	26
FBG	5.38 ± 1.25	5.37 ± 1.28	5.51± 0.63	0.15	0.864
HbA1c	5.17 ± 0.62	5.3 ± 0.56	5.49 ± 0.72	1.63	0.201
BMI	26.54 ± 3.06	25.94 ± 3.81	25.29 ± 2.66	0.79	0.457
Diabetic group	20	71	23
FBG	9.9 ± 1.3	8.1 ± 0.35	7.9 ± 0.35	2.40	0.092
HbA1c	8.7 ± 0.54	8.39 ± 0.25	9.7 ± 1.01	1.70	0.177
BMI	31.3 ± 1.26	30.7 ± 0.75	29.4 ± 1.28	0.58	0.561

BMI: body mass index, FBG: fasting blood glucose, HbA1c: hemoglobin A1c, BMI: body mass index, SNP: single nucleotide polymorphism FTO: fat mass and obesity-associated

Table 4

- Summary of studies on the association of the rs8050136 variant of FTO gene with obesity and T2DM.

Author	Year	Region	Risk allele frequency		P-value
Author	Year	Region	T2DM	Control	P-value
Xiao et al¹⁴	2016	China	0.31	0.28	0.014
Votsi et al¹⁵	2017	Cyprus	0.41	-	0.006
Rong et al¹⁶	2009	USA	0.15	0.14	0.800
Hotta et al¹⁸	2011	Japan	0.40	0.45	0.000
Ramya et al¹⁹	2012	India	0.14	0.11	<0.0001
Chauhan et al²⁰	2011	India	0.35	0.34	0.36
Vatankhah et al²⁶	2020	Iran	0.76	0.74	0.132
Bego et al²⁷	2019	West Balkan	0.50	0.46	0.659
Almawi et al²⁸	2013	Lebanon	0.49	0.55	-
Al-Sinani et al²⁹	2015	Oman	0.46	0.43	0.770
Nikitin et al³⁰	2017	Russia	067	0.67	0.100
Gamboa et al³¹	2012	Mexico	0.19	0.2	0.278
van Herpt et al³²	2017	Netherlands	0.41	0.38	0.45
Xiao et al³⁷	2015	China	0.31	0.27	0.027