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Research ArticleOriginal Article
Open Access

Evaluation of hematological parameters and thrombocytopenia following Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccination

Abdullah Algaissi, Edrous Alamer, Mohammed Jeraiby, Abeer Alomaish, Omer Elrhima, Sultan Qumayi, Naaif A. Qasir, Halima Areeshi, Asma Masmali and Abdulaziz Alhazmi
Saudi Medical Journal June 2022, 43 (6) 567-571; DOI: https://doi.org/10.15537/smj.2022.43.6.20220135
Abdullah Algaissi
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
PhD
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Edrous Alamer
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
PhD
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Mohammed Jeraiby
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
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Abeer Alomaish
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
MD
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Omer Elrhima
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
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Sultan Qumayi
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
MSc
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Naaif A. Qasir
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
BS
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Halima Areeshi
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
BS
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Asma Masmali
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
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Abdulaziz Alhazmi
From the Department of Medical Laboratories Technology (Algaissi, Alamer, Qasir), College of Applied Medical Sciences; form the Department of Emerging and Epidemic Infectious Diseases Research Unit (Algaissi, Alamer, Jeraiby, Alomaish, Qumayi, Qasir, Areeshi, Masmali, Alhazmi) Medical Research Center; from the Department of Biochemistry (Jeraiby); from the Department of Pathology (Elrhima); Department of Microbiology and Parasitology (Alhazmi), College of Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia.
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    Figure 1

    - Pfizer-BioNTech vaccine did not affect platelet counts. A) Platelets were quantified at day 0 (pre vaccine) and 14-22 days post-vaccination. B) Platelets count for study participants at 14-22 days following vaccination. Dashed lines represent upper and lower range values. NS: non-significant, p>0.5. Paired T test was used for the comparison. GraphPad software version 8.1 was used for the statical analysis.

Tables

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    Table 1

    - Demographics of the study participants(N=40).

    Variablen (%)
    Age (median), year*27 (20-58)
    Male,32 (80.0)
    Infected before6 (15.0)
    Comorbidities3 (7.5)
    *range
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    Table 2

    - Side effects after vaccination (N=40).

    Side effectn (%)
    Pain14 (35.0)
    Fever4 (10.0)
    Headache2 (5.0)
    Vomiting1 (2.5)
    Fatigue3 (7.5)
    Cutaneous bleeding0 (0)
    Muscle/joint pain5 (12.5)
    Bruises1 (2.5)
    Bleeding gums0 (0)
    Malaise0 (0)
    Percentage of participants who report the different side effects after receiving one dose of Pfizer-BioNTech (BNT162b2) COVID-19 vaccine
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Saudi Medical Journal: 43 (6)
Saudi Medical Journal
Vol. 43, Issue 6
1 Jun 2022
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Evaluation of hematological parameters and thrombocytopenia following Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccination
Abdullah Algaissi, Edrous Alamer, Mohammed Jeraiby, Abeer Alomaish, Omer Elrhima, Sultan Qumayi, Naaif A. Qasir, Halima Areeshi, Asma Masmali, Abdulaziz Alhazmi
Saudi Medical Journal Jun 2022, 43 (6) 567-571; DOI: 10.15537/smj.2022.43.6.20220135

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Evaluation of hematological parameters and thrombocytopenia following Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccination
Abdullah Algaissi, Edrous Alamer, Mohammed Jeraiby, Abeer Alomaish, Omer Elrhima, Sultan Qumayi, Naaif A. Qasir, Halima Areeshi, Asma Masmali, Abdulaziz Alhazmi
Saudi Medical Journal Jun 2022, 43 (6) 567-571; DOI: 10.15537/smj.2022.43.6.20220135
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Keywords

  • SARS-CoV-2
  • COVID-19 pandemic
  • COVID-19
  • thrombocytopenia
  • vaccine
  • Pfizer-BioNTech
  • platelets

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