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Research ArticleOriginal Article
Open Access

Nicotine and cotinine quantification after a 4-week inhalation of electronic cigarette vapors in male and female mice using UPLC-MS/MS

Fawaz Alasmari, Abdullah F. Alasmari, Ehab Elzayat, Majed M. Alotaibi, Farraj M. Alotaibi, Mohamed W. Attwa, Fars K. Alanazi, Elkhatim H. Abdelgadir, Syed Rizwan Ahmad, Faleh Alqahtani, Salim S. AL-Rejaie and Musaad A. Alshammari
Saudi Medical Journal July 2022, 43 (7) 678-686; DOI: https://doi.org/10.15537/smj.2022.43.7.20220142
Fawaz Alasmari
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Abdullah F. Alasmari
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Ehab Elzayat
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Majed M. Alotaibi
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Farraj M. Alotaibi
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Mohamed W. Attwa
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Fars K. Alanazi
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Elkhatim H. Abdelgadir
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Syed Rizwan Ahmad
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Faleh Alqahtani
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Salim S. AL-Rejaie
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Musaad A. Alshammari
From the Department of Pharmacology and Toxicology (F. Alasmari, F. M. Alotaibi, A. F. Alasmari, Alqahtani, AL-Rejaie, Alshammari); from the Department of Pharmaceutics (Elzayat, Alanazi); from the Department of Pharmaceutical Chemistry (Attwa, Ahmad), College of Pharmacy, King Saud University, and from the Department of Forensic Sciences (M. M. Alotaibi, Abdelgadir), College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Kingdom of Saudi Arabia.
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Nicotine and cotinine quantification after a 4-week inhalation of electronic cigarette vapors in male and female mice using UPLC-MS/MS
Fawaz Alasmari, Abdullah F. Alasmari, Ehab Elzayat, Majed M. Alotaibi, Farraj M. Alotaibi, Mohamed W. Attwa, Fars K. Alanazi, Elkhatim H. Abdelgadir, Syed Rizwan Ahmad, Faleh Alqahtani, Salim S. AL-Rejaie, Musaad A. Alshammari
Saudi Medical Journal Jul 2022, 43 (7) 678-686; DOI: 10.15537/smj.2022.43.7.20220142

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Nicotine and cotinine quantification after a 4-week inhalation of electronic cigarette vapors in male and female mice using UPLC-MS/MS
Fawaz Alasmari, Abdullah F. Alasmari, Ehab Elzayat, Majed M. Alotaibi, Farraj M. Alotaibi, Mohamed W. Attwa, Fars K. Alanazi, Elkhatim H. Abdelgadir, Syed Rizwan Ahmad, Faleh Alqahtani, Salim S. AL-Rejaie, Musaad A. Alshammari
Saudi Medical Journal Jul 2022, 43 (7) 678-686; DOI: 10.15537/smj.2022.43.7.20220142
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Keywords

  • electronic cigarettes
  • nicotine and cotinine
  • gender differences
  • biological detection
  • UPLC-MS/MS

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