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Research ArticleOriginal Article
Open Access

Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

A retrospective study

Abeer S. Alzubaidi and Ahmed F. Basilim
Saudi Medical Journal August 2022, 43 (8) 941-945; DOI: https://doi.org/10.15537/smj.2022.43.8.20220128
Abeer S. Alzubaidi
From the Pharmacy Department (Alzubaidi), and from the Department of Pharmacy Practice (Basilim), Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
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  • For correspondence: [email protected]
Ahmed F. Basilim
From the Pharmacy Department (Alzubaidi), and from the Department of Pharmacy Practice (Basilim), Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
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    Table 1

    - Socio-demographic and clinical characteristics of patients with nonvariceal upper gastrointestinal bleeding (N=97).

    VariablesType of PPIs RegimenP-value
    Intermittent
    (n=56)
    Continuous
    (n=41)
    Age (years; mean ± SD)66.0 ± 16.158.0 ± 19.50.116
    Gender
    Male19 (33.9)13 (31.7)0.345
    Female37 (66.1)28 (68.3)
    Comorbidities
    Hypertension4 (73.2)18 (43.9)0.401
    Diabetes mellitus30 (53.0)17 (41.4) 
    Chronic kidney diseases9 (16.0)5 (12.1) 
    Ischemic heart disease15 (26.7)7 (17.0) 
    Cerebrovascular accident7(12.5)7 (17.0) 
    Peptic ulcer disease5 (8.9)8 (19.5) 
    Heart failure5 (8.9)3 (7.3) 
    Endoscopic findings (Forrest classification)   
    Ia (Spurting)01 
    Ib (Oozing)510 
    IIa (Non-bleeding vessel)36 
    IIb (Adherent clot)22 
    IIc (Flat pigmented spot)34 
    III (Clean based ulcer)4318 

    Values are presented as number and percentage (%). Continuous variables tested using independent sample t-test. Categorical variables tested using Chi-square test. Statistical significance at p<0.05. PPIs: proton pump inhibitors, SD: standard deviation

      • View popup
      Table 2

      - Association between proton pump inhibitors regimen and patients’ outcomes

      OutcomesOverall
      (N=97)
      Type of PPIs regimenP-value
      Intermittent
      (n=56)
      Continuous
      (n=41)
      Rebleeding6 (6.1)5 (8.9)1 (2.4)0.396
      Mortality4 (4.1)1 (1.7)3 (7.3)0.308
      Length of stay (days)9450.067

      Values are presented as number and percentage (%). Categorical variables tested using Chi-square test. Statistical significance at p<0.05. PPIs: proton pump inhibitors

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      Saudi Medical Journal: 43 (8)
      Saudi Medical Journal
      Vol. 43, Issue 8
      1 Aug 2022
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      Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia
      Abeer S. Alzubaidi, Ahmed F. Basilim
      Saudi Medical Journal Aug 2022, 43 (8) 941-945; DOI: 10.15537/smj.2022.43.8.20220128

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      Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia
      Abeer S. Alzubaidi, Ahmed F. Basilim
      Saudi Medical Journal Aug 2022, 43 (8) 941-945; DOI: 10.15537/smj.2022.43.8.20220128
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      Keywords

      • proton pump inhibitor
      • nonvariceal upper gastrointestinal bleeding
      • rebleeding
      • mortality
      • length of hospital stay

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