Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia

A retrospective study

Abeer S. Alzubaidi and Ahmed F. Basilim
Saudi Medical Journal August 2022, 43 (8) 941-945; DOI: https://doi.org/10.15537/smj.2022.43.8.20220128
Abeer S. Alzubaidi
From the Pharmacy Department (Alzubaidi), and from the Department of Pharmacy Practice (Basilim), Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
PharmD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Ahmed F. Basilim
From the Pharmacy Department (Alzubaidi), and from the Department of Pharmacy Practice (Basilim), Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
PharmD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Laine L,
    2. Laursen SB,
    3. Zakko L,
    4. Dalton HR,
    5. Ngu JH,
    6. Schultz M et al.
    Severity and outcomes of upper gastrointestinal bleeding with bloody Vs. coffee-grounds hematemesis. Am J Gastroenterol 2018; 113: 358–366.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Lanas A,
    2. Dumonceau JM,
    3. Hunt RH,
    4. Fujishiro M,
    5. Scheiman JM,
    6. Gralnek IM et al.
    Nonvariceal upper gastrointestinal bleeding. Nat Rev Dis Primers 2018; 4: 18020.
    OpenUrl
  3. 3.↵
    1. Han C,
    2. Ling X,
    3. Liu J,
    4. Lin R and
    5. Ding Z
    . Management of nonvariceal upper gastrointestinal bleeding: role of endoscopic ultrasound-guided treatments. Therap Adv Gastroenterol 2022; 15: 175.
    OpenUrl
  4. 4.↵
    1. Alzoubaidi D,
    2. Lovat LB,
    3. Haidry R
    . Management of nonvariceal upper gastrointestinal bleeding: where are we in 2018? Frontline Gastroenterol 2019; 10: 35–42.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Kherad O,
    2. Restellini S,
    3. Martel M,
    4. Barkun A
    . Proton pump inhibitors for upper gastrointestinal bleeding. Best Pract Res Clin Gastroenterol 2019; 42-43: 101609.
    OpenUrl
  6. 6.↵
    1. Mujtaba S,
    2. Chawla S,
    3. Massaad JF
    . Diagnosis and management of nonvariceal gastrointestinal hemorrhage: a review of current guidelines and future perspectives. J Clin Med 2020; 9: 402.
    OpenUrl
  7. 7.↵
    1. Laine L,
    2. Barkun AN,
    3. Saltzman JR,
    4. Martel M,
    5. Leontiadis GI
    . ACG clinical guideline: upper gastrointestinal and ulcer bleeding. Am J Gastroenterol 2021; 116: 899–917.
    OpenUrlPubMed
  8. 8.↵
    1. Zhu W,
    2. Chen L,
    3. Zhang J,
    4. Wang P
    . Effects of high-dose versus low-dose proton pump inhibitors for treatment of gastrointestinal ulcer bleeding: a meta-analysis of randomized controlled trials. J Int Med Res 2022; 50: 3000605211067396.
    OpenUrl
  9. 9.↵
    1. Sachar H,
    2. Vaidya K,
    3. Laine L
    . Intermittent vs continuous proton pump inhibitor therapy for high-risk bleeding ulcers: a systematic review and meta-analysis. JAMA Intern Med 2014; 174: 1755–1762.
    OpenUrl
  10. 10.↵
    1. Worden JC,
    2. Hanna KS
    . Optimizing proton pump inhibitor therapy for treatment of nonvariceal upper gastrointestinal bleeding. Am J Health Syst Pharm 2017; 74: 109–116.
    OpenUrlAbstract/FREE Full Text
  11. 11.↵
    1. Hajiagha Mohammadi AA,
    2. Reza Azizi M
    . Prognostic factors in patients with active nonvariceal upper gastrointestinal bleeding. Arab J Gastroenterol 2019; 20: 23–27.
    OpenUrl
  12. 12.↵
    1. Almadi MA,
    2. Almutairdi A,
    3. Alruzug IM,
    4. Aldarsouny TA,
    5. Semaan T,
    6. Aldaher MK et al.
    Upper gastrointestinal bleeding: Causes and patient outcomes. Saudi J Gastroenterol 2021; 27: 20–27.
    OpenUrl
  13. 13.↵
    1. Kim MS,
    2. Moon HS,
    3. Kwon IS,
    4. Park JH,
    5. Kim JS,
    6. Kang SH et al.
    Validation of a new risk score system for nonvariceal upper gastrointestinal bleeding. BMC Gastroenterol 2020; 20: 193.
    OpenUrl
  14. 14.↵
    1. Barkun AN,
    2. Almadi M,
    3. Kuipers EJ,
    4. Laine L,
    5. Sung J,
    6. Tse F et al.
    Management of nonvariceal upper gastrointestinal bleeding: guideline recommendations from the International Consensus Group. Ann Intern Med 2019; 171: 805–822.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Masoodi I,
    2. AlQurashi H,
    3. Al Sofiyani M
    . Changing trends in acute upper GI bleeding a single-centre study in the western region of Saudi Arabia. Br J Medical Pract 2019; 12: a019.
    OpenUrl
  16. 16.↵
    1. Leung T,
    2. Kedzior S,
    3. Moore K,
    4. Bierman J,
    5. Coralic Z
    . Intermittent versus continuous infusion dosing of intravenous proton pump inhibitors for upper gastrointestinal bleeding. Ann Pharmacother 2022; 0: 10600280211073936.
  17. 17.↵
    1. Mahajan U,
    2. Kapoor D,
    3. Rana BS,
    4. Kumar P,
    5. Kumar D,
    6. Malakar S, et al.
    A study to compare the efficacy of intermittent versus continuous regimen of pantaprazole in the management of upper gastrointestinal bleed (non variceal). Int J Med Sci 2018; 6: 3488.
    OpenUrl
  18. 18.↵
    1. Ibrahim E,
    2. Koptan H
    . The effectiveness of standard single dose omeprazole vs. High dose continuous infusion in high-risk critically ill patients. J Anesth Clin Res 2018; 9: 2.
    OpenUrl
  19. 19.↵
    1. Khan RS,
    2. Hadi YB,
    3. Chima N,
    4. Kupec J
    . Skipping the drip: intravenous proton pump inhibitor bolus therapy leads to poor outcomes in high-risk bleeding. Cureus 2020; 12: e8362.
    OpenUrl
  20. 20.↵
    1. Hsu YC,
    2. Perng CL,
    3. Yang TH,
    4. Wang CS,
    5. Hsu WL,
    6. Wu HT, et al.
    A randomized controlled trial comparing two different dosages of infusional pantoprazole in peptic ulcer bleeding. Br J Clin Pharmacol 2010; 69: 245–251.
    OpenUrlPubMed
  21. 21.↵
    1. Neumann I,
    2. Letelier LM,
    3. Rada G,
    4. Claro JC,
    5. Martin J,
    6. Howden CW, et al.
    Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding. Cochrane Database Syst Rev 2013: CD007999.
  22. 22.↵
    1. Ahmed Al-shargi OY,
    2. Ayesh Mohammed Saghir S,
    3. Al-balagi N,
    4. Hayat A
    . Knowledge assessment of symptoms identification of acute heart attack among staff and students of University Sains Malaysia. Int J Pharm Sci Res 2020; 65: 1–9.
    OpenUrl
  23. 23.↵
    1. Yahya Alshargi O,
    2. Mukhlef Alzaid S
    , ibrahim Albahouth Z, Ali Jaber A, Al-Dosari BS. Clinical applications of pharmacometabonomics in neurology: Current status, future perspectives and challenges. Res J Pharm Technol 2022; 15: 976–980.
    OpenUrl
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 43 (8)
Saudi Medical Journal
Vol. 43, Issue 8
1 Aug 2022
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia
Abeer S. Alzubaidi, Ahmed F. Basilim
Saudi Medical Journal Aug 2022, 43 (8) 941-945; DOI: 10.15537/smj.2022.43.8.20220128

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia
Abeer S. Alzubaidi, Ahmed F. Basilim
Saudi Medical Journal Aug 2022, 43 (8) 941-945; DOI: 10.15537/smj.2022.43.8.20220128
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Prolonged flight exposure and its effects on sinonasal health among aircrew members
  • Identifying individuals at risk of post-stroke depression
  • Hematological parameters in recent and past dengue infections in Jazan Province, Saudi Arabia
Show more Original Article

Similar Articles

Keywords

  • proton pump inhibitor
  • nonvariceal upper gastrointestinal bleeding
  • rebleeding
  • mortality
  • length of hospital stay

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire