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Research ArticleOriginal Article
Open Access

Single nucleotide polymorphisms in cytokine genes and their association with primary Sjögren’s syndrome in Saudi patients

A cross-sectional study

Bashaer Alqahtani, Maha Daghestani, Mohammed A. Omair, Fahidah Alenzi, Esam H. Alhamad, Yusra Tashkandy, Nashwa Othman, Arjumand Warsy and Rabih Halwani
Saudi Medical Journal December 2023, 44 (12) 1232-1239; DOI: https://doi.org/10.15537/smj.2023.44.12.20230490
Bashaer Alqahtani
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Maha Daghestani
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Mohammed A. Omair
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Fahidah Alenzi
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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  • ORCID record for Fahidah Alenzi
  • For correspondence: [email protected]
Esam H. Alhamad
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Yusra Tashkandy
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Nashwa Othman
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Arjumand Warsy
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Rabih Halwani
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Saudi Medical Journal: 44 (12)
Saudi Medical Journal
Vol. 44, Issue 12
1 Dec 2023
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Single nucleotide polymorphisms in cytokine genes and their association with primary Sjögren’s syndrome in Saudi patients
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Single nucleotide polymorphisms in cytokine genes and their association with primary Sjögren’s syndrome in Saudi patients
Bashaer Alqahtani, Maha Daghestani, Mohammed A. Omair, Fahidah Alenzi, Esam H. Alhamad, Yusra Tashkandy, Nashwa Othman, Arjumand Warsy, Rabih Halwani
Saudi Medical Journal Dec 2023, 44 (12) 1232-1239; DOI: 10.15537/smj.2023.44.12.20230490

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Single nucleotide polymorphisms in cytokine genes and their association with primary Sjögren’s syndrome in Saudi patients
Bashaer Alqahtani, Maha Daghestani, Mohammed A. Omair, Fahidah Alenzi, Esam H. Alhamad, Yusra Tashkandy, Nashwa Othman, Arjumand Warsy, Rabih Halwani
Saudi Medical Journal Dec 2023, 44 (12) 1232-1239; DOI: 10.15537/smj.2023.44.12.20230490
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Keywords

  • Primary Sjögren’s syndrome (pSS)
  • Single nucleotide polymorphism (SNP)
  • Interleukin-1 beta (IL-1β)
  • Interferon regulatory factor 5 (IRF5)
  • B-cell activating factor (BAFF)

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