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Research ArticleOriginal Article
Open Access

Single nucleotide polymorphisms in cytokine genes and their association with primary Sjögren’s syndrome in Saudi patients

A cross-sectional study

Bashaer Alqahtani, Maha Daghestani, Mohammed A. Omair, Fahidah Alenzi, Esam H. Alhamad, Yusra Tashkandy, Nashwa Othman, Arjumand Warsy and Rabih Halwani
Saudi Medical Journal December 2023, 44 (12) 1232-1239; DOI: https://doi.org/10.15537/smj.2023.44.12.20230490
Bashaer Alqahtani
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
PhD
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Maha Daghestani
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
MD, PhD
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Mohammed A. Omair
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
MD
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Fahidah Alenzi
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
MD
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  • ORCID record for Fahidah Alenzi
  • For correspondence: [email protected]
Esam H. Alhamad
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
MD
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Yusra Tashkandy
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
PhD
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Nashwa Othman
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Arjumand Warsy
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
PhD
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Rabih Halwani
From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
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Article Information

vol. 44 no. 12 1232-1239
DOI 
https://doi.org/10.15537/smj.2023.44.12.20230490
PubMed 
38016737

Published By 
Saudi Medical Journal
Online ISSN 
1658-3175
History 
  • Received July 6, 2023
  • Accepted October 5, 2023
  • Published online November 28, 2023.

Copyright & Usage 
Copyright: © Saudi Medical Journal This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

Author Information

  1. Bashaer Alqahtani, PhD,
  2. Maha Daghestani, MD, PhD,
  3. Mohammed A. Omair, MD,
  4. Fahidah Alenzi, MD⇑,
  5. Esam H. Alhamad, MD,
  6. Yusra Tashkandy, PhD,
  7. Nashwa Othman, PhD,
  8. Arjumand Warsy, PhD and
  9. Rabih Halwani, MD
  1. From the Department of Zoology (Alqahtani, Daghestani); from the Department of Medicine (Omair), Rheumatology Division; from the Department of Medicine (Alhamad), Pulmonary Division; from the Department of Statistics and Operations Research (Tashkandy), College of Sciences; from the Central Laboratory (Othman); from the Department of Biochemistry (Warsy), King Saud University; from the Department of Clinical Sciences (Alenzi), College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia; and from Department of Clinical Sciences (Halwani), Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
  1. Address correspondence and reprint request to: Dr. Fahidah Alenzi, Department of Clinical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. E-mail: Fmalenzi{at}pnu.edu.sa
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Single nucleotide polymorphisms in cytokine genes and their association with primary Sjögren’s syndrome in Saudi patients
Bashaer Alqahtani, Maha Daghestani, Mohammed A. Omair, Fahidah Alenzi, Esam H. Alhamad, Yusra Tashkandy, Nashwa Othman, Arjumand Warsy, Rabih Halwani
Saudi Medical Journal Dec 2023, 44 (12) 1232-1239; DOI: 10.15537/smj.2023.44.12.20230490

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Single nucleotide polymorphisms in cytokine genes and their association with primary Sjögren’s syndrome in Saudi patients
Bashaer Alqahtani, Maha Daghestani, Mohammed A. Omair, Fahidah Alenzi, Esam H. Alhamad, Yusra Tashkandy, Nashwa Othman, Arjumand Warsy, Rabih Halwani
Saudi Medical Journal Dec 2023, 44 (12) 1232-1239; DOI: 10.15537/smj.2023.44.12.20230490
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Keywords

  • Primary Sjögren’s syndrome (pSS)
  • Single nucleotide polymorphism (SNP)
  • Interleukin-1 beta (IL-1β)
  • Interferon regulatory factor 5 (IRF5)
  • B-cell activating factor (BAFF)

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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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