Article Figures & Data
Figures
- Figure 1
- Percentage of lymphocytes in T2DM patients and healthy individuals. Lymphocytes were isolated from the peripheral blood of the T2DM patients and healthy individuals based on SSC and FSC using flow cytometry. A) Dot plots showing the percentage of lymphocytes in the samples obtained from healthy individuals and T2DM patients. B) The percentage of lymphocytes in both groups is presented. Data were analyzed using an unpaired t-test. Values are presented as mean±SD. ***p≤0.001, T2DM: type 2 diabetes mellitus, SSC: side scatter, FSC: forward scatter
- Figure 2
- Levels of B-lymphocytes and their subsets in T2DM patients and healthy individuals. Lymphocytes were isolated from the peripheral blood of the T2DM patients and healthy individuals. The cells were then stained with anti-CD19 (FITC), CD27 (PerCyp Cy5.5), and CD38 (APC) and analyzed using flow cytometry. A) Representative dot plots showing the percentage of CD19+ B-cells in the samples obtained from healthy individuals and T2DM patients. B) The percentage of CD19+ cells in both groups is presented. C) Representative dot plots showing the percentage of B-cell subsets in the samples obtained from healthy individuals and T2DM according to CD27 and CD38 expression. D) The percentage of CD27-/CD38+ cells in both groups is presented. E) The percentage of CD27+/CD38- cells in both groups is presented. Data were analyzed using an unpaired t-test. Values are presented as mean±SD. ***p≤0.001, ****p≤0.0001, T2DM: type 2 diabetes mellitus
- Figure 3
- Levels of T-lymphocytes and subsets in T2DM patients and healthy individuals. Lymphocytes were isolated from the peripheral blood of T2DM patients and healthy individuals. The cells were then stained with anti-CD3 (APC Cy7), CD4 (APC), and CD8 (PE) and analyzed using flow cytometry. A) Dot plots showing the percentage of CD3+ T-cells in the samples obtained from healthy individuals and T2DM patients. B) The percentage of CD3+ cells in both groups is presented. C) Dot plots showing the percentage of CD4 and CD8 T-cells in the samples obtained from healthy individuals and T2DM patients. D) The percentage of CD4+ cells; and E) CD8+ cells in both groups is presented. Data were analyzed using an unpaired t-test. Values are presented as mean±SD. *p≤0.05, T2DM: type 2 diabetes mellitus
- Figure 4
- Levels of NK cells in T2DM patients and healthy individuals. Lymphocytes were isolated from the peripheral blood of the T2DM patients and healthy individuals. The cells were then stained with anti-CD3 (APC Cy7), and CD56 (PE) and analyzed using flow cytometry. A) Dot plots showing the percentage of CD3-/CD56+ NK cells in the samples obtained from healthy individuals and T2DM patients. B) The percentage of NK cells in both groups is presented. Data were analyzed using an unpaired t-test. Values are presented as mean±SD. **p≤0.01, T2DM: type 2 diabetes mellitus
- Figure 5
- Expression of monocyte subsets in T2DM patients and healthy individuals. Monocytes were isolated from the peripheral blood of the T2DM patients and healthy individuals. The cells were then stained with anti-CD14 (APC Cy7), and CD16 (FITC) and analyzed using flow cytometry. A) Dot plots showing the percentage of monocyte subsets in the samples obtained from healthy individuals and T2DM patients. B) The percentage of CD14+ cells; C) CD14+/CD16+; and D) CD16+ in both groups are presented. Data were analyzed using an unpaired t-test. Values are presented as mean±SD. *p≤0.05, ***p≤0.001. T2DM: type 2 diabetes mellitus
Tables
Parameters T2DM Healthy controls Age (years), mean±SD 59±9.1 46±5.3 Gender MaleFemale 33 (53.2)29 (46.8) 19 (57.5)14 (42.5) HbA1c (%), mean±SD 8.6±2.3 5.3±1.4 Values are presented as numbers and precentages (%) or mean ± standard deviation (SD). HbA1c: hemoglobin A1c, T2DM: type 2 diabetes mellitus
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