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Variables Total samples (n=428, 100%) Control group (n=217, 50.7%) T2DM group (n=211, 49.3%) P-value Gender, n (%) Male 198 (46.3) 101 (46.5) 97 (46.0) 0.905* Female 230 (53.7) 116 (53.5) 114 (54.0) Age (years) 53.5±13.3 50.1±13.6 57.1±11.9 <0.0001 Weight (kg) 72.6±13.4 70.3±13.1 75.1±13.4 0.0005 Height (cm) 161±8.04 162±7.06 161±8.86 0.1333 BMI (kg/m2) 27.6±5.05 26.5±5.07 28.8±4.77 <0.0001 FPG (mmol/L) 7.43±2.19 5.47±0.546 8.97±1.71 <0.0001 HbA1c (%) 9.44±5.50 5.65±1.04 12.5±5.73 <0.0001 Family history, n (%) 119 (27.8) 38 (17.5) 81 (38.3) <0.0001* Data represent means±standard deviation unless otherwise specified. T2DM: type 2 diabetes mellitus, BMI: body mass index, FPG: fasting plasma glucose, HbA1c: glycated hemoglobin. *Chi-square (χ2) test.
- Table 2
- Genotype and allele distribution of sirtuin2 (SIRT2) rs2015 and rs2241703 in control and type 2 diabetes mellitus (T2DM) groups.
Genotype/Allele Total N=428 Control n=217 T2DM n=211 HWE P-value P-value* rs2015 GG 126 (29.4) 59 (27.2) 67 (31.7) 0.172 0.308 GT 195 (45.6) 102 (47.0) 93 (44.1) 0.548 TT 107 (25.0) 56 (25.8) 51 (24.2) 0.703 G 447 (52.2) 220 (50.7) 227 (53.8) 0.521 T 409 (47.8) 214 (49.3) 195 (46.2) 0.521 rs2241703 GG 428 (100) 217 (100) 211 (100) NA NA GA 0 0 0 NA AA 0 0 0 NA G 856 (100) 434 (100) 411 (100) NA A 0 0 0 NA Values are presented as number and percentages (%). *Chi-square χ2) test. NA: not applicable
- Table 3
- Binomial logistic regression analysis of type 2 diabetes mellitus (T2DM) and control groups
Model Genotype/allele OR (95% CI) P-value Codominant GT vs. GG 0.803 (0.51 to 1.25) 0.362 TT vs. GG 0.802 (0.47 to 1.33) 0.402 Dominant GT+TT vs. GG 0.803 (0.53 to 1.20) 0.301 Recessive TT vs. GT+GG 1.091 (0.71 to 1.67) 0.696 Additive T 0.883 (0.67 to 1.16) 0.374 OR: odd ratio, CI: confidence interval, vs: versus
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