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Research ArticleOriginal Article
Open Access

Application of serum gastric function markers and digestive tumor indices to the diagnosis of early gastric cancer and precancerous lesions

Zhu Yanan, Wang Juan, Wang Jun, Ma Xin, Wu Kejian and Wang Fangyu
Saudi Medical Journal August 2023, 44 (8) 795-800; DOI: https://doi.org/10.15537/smj.2023.44.8.20230231
Zhu Yanan
From the Department of Gastroenterology and Hepatology (Yanan, Fangyu), Jinling Hospital, Jinling Clinical College of Nanjing Medical University, Nanjing, and from the Department of Gastroenterology (Yanan, Juan, Jun, Xin, Kejian), the affiliated Hospital of Xuzhou Medical University, XuZhou, China.
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Wang Juan
From the Department of Gastroenterology and Hepatology (Yanan, Fangyu), Jinling Hospital, Jinling Clinical College of Nanjing Medical University, Nanjing, and from the Department of Gastroenterology (Yanan, Juan, Jun, Xin, Kejian), the affiliated Hospital of Xuzhou Medical University, XuZhou, China.
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Wang Jun
From the Department of Gastroenterology and Hepatology (Yanan, Fangyu), Jinling Hospital, Jinling Clinical College of Nanjing Medical University, Nanjing, and from the Department of Gastroenterology (Yanan, Juan, Jun, Xin, Kejian), the affiliated Hospital of Xuzhou Medical University, XuZhou, China.
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Ma Xin
From the Department of Gastroenterology and Hepatology (Yanan, Fangyu), Jinling Hospital, Jinling Clinical College of Nanjing Medical University, Nanjing, and from the Department of Gastroenterology (Yanan, Juan, Jun, Xin, Kejian), the affiliated Hospital of Xuzhou Medical University, XuZhou, China.
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Wu Kejian
From the Department of Gastroenterology and Hepatology (Yanan, Fangyu), Jinling Hospital, Jinling Clinical College of Nanjing Medical University, Nanjing, and from the Department of Gastroenterology (Yanan, Juan, Jun, Xin, Kejian), the affiliated Hospital of Xuzhou Medical University, XuZhou, China.
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Wang Fangyu
From the Department of Gastroenterology and Hepatology (Yanan, Fangyu), Jinling Hospital, Jinling Clinical College of Nanjing Medical University, Nanjing, and from the Department of Gastroenterology (Yanan, Juan, Jun, Xin, Kejian), the affiliated Hospital of Xuzhou Medical University, XuZhou, China.
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References

  1. 1.↵
    1. Leung WK,
    2. Wu MS,
    3. Kakugawa Y,
    4. Kim JJ,
    5. Yeoh KG,
    6. Goh KL, et al.
    Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol 2008; 9: 279–287.
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.↵
    1. Loor A,
    2. Dumitraşcu DL.
    Helicobacter pylori infection, gastric cancer and gastropanel. Rom J Intern Med 2016; 54: 151–156.
    OpenUrl
  3. 3.↵
    1. Duraker N,
    2. Celik AN.
    The prognostic significance of preoperative serum CA 19-9 in patients with resectable gastric carcinoma: comparison with CEA. J Surg Oncol 2001; 76: 266–271.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Miki K.
    Gastric cancer screening using the serum pepsinogen test method. Gastric Cancer 2006; 9: 245–253.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Dinis-Ribeiro M,
    2. da Costa-Pereira A,
    3. Lopes C,
    4. Barbosa J,
    5. Guilherme M,
    6. Moreira-Dias L, et al.
    Validity of serum pepsinogen I/II ratio for the diagnosis of gastric epithelial dysplasia and intestinal metaplasia during the follow-up of patients at risk for intestinal-type gastric adenocarcinoma. Neoplasia 2004; 6: 449–456.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Gamboa-Dominguez A,
    2. Seidl S,
    3. Reyes-Gutierrez E,
    4. Hermannstädter C,
    5. Quintanilla-Martinez L,
    6. Busch R, et al.
    Prognostic significance of p21WAF1/CIP1, p27Kip1, p53, and E-cadherin expression in gastric cancer. J Clin Pathol 2007; 60: 756–761.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Bray F,
    2. Ferlay J,
    3. Soerjomataram I,
    4. Siegel RL,
    5. Torre LA,
    6. Jemal A.
    Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394–424.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Mukoubayashi C,
    2. Yanaoka K,
    3. Ohata H,
    4. Arii K,
    5. Tamai H,
    6. Oka M, et al.
    Serum pepsinogen and gastric cancer screening. Intern Med 2007; 46: 261–266.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Hamashima C.
    Update version of the Japanese Guidelines for Gastric Cancer Screening. Jpn J Clin Oncol 2018; 48: 673–683.
    OpenUrlPubMed
  10. 10.↵
    1. Jun JK,
    2. Choi KS,
    3. Lee HY,
    4. Suh M,
    5. Park B,
    6. Song SH, et al.
    Effectiveness of the Korean National Cancer Screening Program in reducing gastric cancer mortality. Gastroenterology 2017; 152: 1319–1328.
    OpenUrlPubMed
  11. 11.↵
    1. Miki K.
    Gastric cancer screening by combined assay for serum anti-Helicobacter pylori IgG antibody and serum pepsinogen levels - “ABC method”. Proc Jpn Acad Ser B Phys Biol Sci 2011; 87: 405–414.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Miki K,
    2. Morita M,
    3. Sasajima M,
    4. Hoshina R,
    5. Kanda E,
    6. Urita Y.
    Usefulness of gastric cancer screening using the serum pepsinogen test method. Am J Gastroenterol 2003; 98: 735–739.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Derakhshan MH,
    2. El-Omar E,
    3. Oien K,
    4. Gillen D,
    5. Fyfe V,
    6. Crabtree JE, et al.
    Gastric histology, serological markers, and age as predictors of gastric acid secretion in patients infected with Helicobacter pylori. J Clin Pathol 2006; 59: 1293–1299.
    OpenUrlAbstract/FREE Full Text
  14. 14.↵
    1. Colacci E,
    2. Pasquali A,
    3. Severi C.
    Exocrine gastric secretion and gastritis: pathophysiological and clinical relationships. Clin Ter 2011; 162: e19–e25.
    OpenUrlPubMed
  15. 15.↵
    1. De Marco MO,
    2. Tustumi F,
    3. Brunaldi VO,
    4. Resende RH,
    5. Matsubayashi CO,
    6. Baba ER, et al.
    Prognostic factors for ESD of early gastric cancers: a systematic review and meta-analysis. Endosc Int Open 2020; 8: E1144–E1155.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Deng M,
    2. Zhang L,
    3. Zheng W,
    4. Chen J,
    5. Du N,
    6. Li M, et al.
    Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression. J Exp Clin Cancer Res 2023; 42: 9.
    OpenUrl
  17. 17.↵
    1. Kohansal M,
    2. Ghanbarisad A,
    3. Tabrizi R,
    4. Daraei A,
    5. Kashfi M,
    6. Tang H, et al.
    tRNA-derived fragments in gastric cancer: biomarkers and functions. J Cell Mol Med 2022; 26: 4768–4780.
    OpenUrl
  18. 18.↵
    1. Tan YK,
    2. Fielding JW.
    Early diagnosis of early gastric cancer. Eur J Gastroenterol Hepatol 2006; 18: 821–829.
    OpenUrlCrossRefPubMedWeb of Science
  19. 19.↵
    1. Wang W,
    2. Chen XL,
    3. Zhao SY,
    4. Xu YH,
    5. Zhang WH,
    6. Liu K, et al.
    Prognostic significance of preoperative serum CA125, CA19-9, and CEA in gastric carcinoma. Oncotarget 2016; 7: 35423–35436.
    OpenUrl
  20. 20.↵
    1. Liang Y,
    2. Wang W,
    3. Fang C,
    4. Raj SS,
    5. Hu WM,
    6. Li QW, et al.
    Clinical significance and diagnostic value of serum CEA, CA19-9, and CA72-4 in patients with gastric cancer. Oncotarget 2016; 7: 49565–49573.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Lukaszewicz-Zając M,
    2. Mroczko B,
    3. Gryko M,
    4. Kędra B,
    5. Szmitkowski M.
    Comparison between clinical significance of serum proinflammatory proteins (IL-6 and CRP) and classic tumor markers (CEA and CA 19-9) in gastric cancer. Clin Exp Med 2011; 11: 89–96.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Zhu ZB,
    2. De SH,
    3. Zhang LH,
    4. Wang XH,
    5. Xing XF et al.
    Clinical value of serum CEA, CA19-9, CA72-4, and CA242 in the diagnosis and prognosis of gastric cancer. Zhonghua Wei Chang Wai Ke Za Zhi 2012: 15: 161–164.
    OpenUrlPubMed
  23. 23.↵
    1. Kim DH,
    2. Lee HI,
    3. Nam ES,
    4. Shin HS,
    5. Sohn JH,
    6. Park CH, et al.
    Reduced expression of the cell-cycle inhibitor p27Kip1 is associated with progression and lymph node metastasis of gastric carcinoma. Histopathology 2000; 36: 245–251.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.↵
    1. Kumari S,
    2. Kumar P,
    3. Kumar M,
    4. Singh S,
    5. Narayan G.
    Expression of p27 and p16 and their clinical significance in gastric cancer. Clin Transl Oncol 2021; 23: 856–865.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. Correa P,
    2. Piazuelo MB,
    3. Wilson KT.
    Pathology of gastric intestinal metaplasia: clinical implications. Am J Gastroenterol 2010; 105: 493–498.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Jo MJ,
    2. Lee JH,
    3. Nam BH,
    4. Kook MC,
    5. Ryu KW,
    6. Choi IJ, et al.
    Preoperative serum angiopoietin-2 levels correlate with lymph node status in patients with early gastric cancer. Ann Surg Oncol 2009; 16: 2052–2057.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Maehara Y,
    2. Kakeji Y,
    3. Oda S,
    4. Baba H,
    5. Sugimachi K.
    Tumor growth patterns and biological characteristics of early gastric carcinoma. Oncology 2001; 61: 102–112.
    OpenUrlCrossRefPubMed
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Application of serum gastric function markers and digestive tumor indices to the diagnosis of early gastric cancer and precancerous lesions
Zhu Yanan, Wang Juan, Wang Jun, Ma Xin, Wu Kejian, Wang Fangyu
Saudi Medical Journal Aug 2023, 44 (8) 795-800; DOI: 10.15537/smj.2023.44.8.20230231

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Application of serum gastric function markers and digestive tumor indices to the diagnosis of early gastric cancer and precancerous lesions
Zhu Yanan, Wang Juan, Wang Jun, Ma Xin, Wu Kejian, Wang Fangyu
Saudi Medical Journal Aug 2023, 44 (8) 795-800; DOI: 10.15537/smj.2023.44.8.20230231
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