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Research ArticleOriginal Article
Open Access

Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances

Jamil M. Obaid, Sultan A. Saghir, Amir M. Al-Hroob, Shaima A. Mohammed, Ola’a A. Melhi, Ashgan A. Alhomamy and Elham A. Al-Qodaimi
Saudi Medical Journal October 2024, 45 (10) 1064-1070; DOI: https://doi.org/10.15537/smj.2024.45.10.20240308
Jamil M. Obaid
From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma’an, Jordan.
PhD
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  • ORCID record for Jamil M. Obaid
  • For correspondence: [email protected]
Sultan A. Saghir
From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma’an, Jordan.
PhD
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Amir M. Al-Hroob
From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma’an, Jordan.
PhD
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Shaima A. Mohammed
From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma’an, Jordan.
BSC, MLS
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Ola’a A. Melhi
From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma’an, Jordan.
BSC, MLS
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Ashgan A. Alhomamy
From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma’an, Jordan.
BSC, MLS
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Elham A. Al-Qodaimi
From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma’an, Jordan.
BSC, MLS
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  • Article
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Article Figures & Data

Tables

    • View popup
    Table 1

    - Healthy Yemeni participant’s gender, age, ABO phenotype, Rh groups, and secretor status.

    Variablesn (%)
    Gender
    Male140 (65.1)
    Female75 (34.9)
    Age (years)
    10-2047 (21.9)
    21-30116 (53.9)
    31-4035 (16.3)
    41-6017 (7.9)
    ABO blood group
    A76 (35.4)
    B42 (19.5)
    AB26 (12.1)
    O71 (33.0)
    Rh blood group
    D positive174 (81.9)
    D negative41 (19.1)
    Secretor state
    Secretor168 (78.1)
    Non-secretor47 (21.9)

    Values are presented as numbers and percentages (%).

      • View popup
      Table 2

      - Mouth and teeth health data among healthy Yemeni participants.

      Variablesn (%)
      Periodontal or teeth problems
      Yes126 (58.6)
      No89 (41.4)
      Brush teeth
      Several times per day12 (5.6)
      Daily27 (12.6)
      Weekly45 (20.9)
      Monthly42 (19.5)
      No89 (41.4)
      Gum consumption
      Yes74 (34.4)
      No141 (65.6)
      Smoking
      Yes46 (21.4)
      No169 (78.6)
      Qat chawing
      Yes165 (76.7)
      No50 (23.3)

      Values are presented as numbers and percentages (%).

        • View popup
        Table 3

        - Secretor prevalence and its association with Yemeni participant’s gender and age.

        VariablesSecretorsNon-secretorsORs95% CIsP-values
        Gender
        Male112 (80.0)28 (20.0)1.460.75-2.810.344
        Female55 (73.3)20 (26.7)
        Age groups
        10-2032 (68.1)15 (31.9)---
        21-3090 (77.6)26 (22.4)1.620.76-3.440.205
        31-4031 (88.6)4 (11.4)3.631.09-12.160.026
        41-5012 (85.7)2 (14.3)2.810.56-14.180.172
        51-602 (66.7)1 (33.3)0.940.08-11.170.695

        Values are presented as numbers and percentages (%). ORs: odds ratios, CIs: confidence intervals

          • View popup
          Table 4

          - Association between secretion status with ABO and Rh blood group phenotypes.

          Secretion statusEvent blood groupNon-event blood groupORs95% CIsP-values
           ANon-A   
          Secretor55 (72.0)112 (81.0)0.630.33-1.220.226
          Non-secretors21 (28.0)27 (19.0)
           BNon-B   
          Secretor30 (71.0)137 (79.0)0.660.31-1.410.380
          Non-secretors12 (29.0)36 (21.0)
           ABNon-AB   
          Secretor14 (54.0)153 (81.0)0.280.12-0.640.004
          Non-secretors12 (46.0)36 (19.0)
           ONon-O   
          Secretor67 (95.0)100 (69.0)7.372.53-21.47<0.001
          Non-secretors4 (5.0)44 (31.0)
           Rh positiveRh negative   
          Secretor131 (76.0)36 (83.0)0.620.26-1.500.390
          Non-secretors41 (24.0)7 (17.0)

          Values are presented as numbers and percentages (%). ORs: odds ratios, CIs: confidence intervals

            • View popup
            Table 5

            - Secretor frequency and its association with potential of hydrogen and consistence properties of saliva.

            Saliva characteristicsSecretorsNon-secretorsORs95% CIsP-values
            pH
            Acidic92 (82.2)20 (17.8)1.720.90-3.290.140
            Alkalin75 (72.8)28 (27.2)
            Consistency
            Normal watery clear97 (75.8)31 (24.2)---
            Frothy bubbly34 (79.1)9 (20.9)1.210.52-2.790.659
            Sticky frothy36 (81.8)8 (18.2)1.440.61-3.420.409

            Values are presented as numbers and percentages (%). ORs: odds ratios, CIs: confidence intervals

              • View popup
              Table 6

              - Secretor status frequency and association with teeth problems history.

              Total teeth scoreSecretorsNon-secretorsORs95% CIsP-values
              068 (76.4)21 (23.6)---
              149 (80.3)12 (19.7)1.260.57-2.800.712
              226 (76.5)8 (23.5)1.010.40-2.550.818
              311 (78.6)3 (21.4)1.130.29-4.440.871
              4 or more13 (76.5)4 (23.5)1.010.30-3.410.760

              Values are presented as numbers and percentages (%). ORs: odds ratios, CIs: confidence intervals

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              Saudi Medical Journal: 45 (10)
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              1 Oct 2024
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              Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances
              Jamil M. Obaid, Sultan A. Saghir, Amir M. Al-Hroob, Shaima A. Mohammed, Ola’a A. Melhi, Ashgan A. Alhomamy, Elham A. Al-Qodaimi
              Saudi Medical Journal Oct 2024, 45 (10) 1064-1070; DOI: 10.15537/smj.2024.45.10.20240308

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              Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances
              Jamil M. Obaid, Sultan A. Saghir, Amir M. Al-Hroob, Shaima A. Mohammed, Ola’a A. Melhi, Ashgan A. Alhomamy, Elham A. Al-Qodaimi
              Saudi Medical Journal Oct 2024, 45 (10) 1064-1070; DOI: 10.15537/smj.2024.45.10.20240308
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              Keywords

              • secretors
              • ABO system
              • ABH antigens
              • hemagglutination inhibition method
              • saliva
              • Yemen

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