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Research ArticleOriginal Article
Open Access

Differentiating mycosis fungoides lesions from their mimickers clinically and histologically

A single tertiary center retrospective analysis in Saudi Arabia

Fatimah M. Budair, Ahmed A. Alsayyah and Omar M. Alakloby
Saudi Medical Journal December 2024, 45 (12) 1355-1367; DOI: https://doi.org/10.15537/smj.2024.45.12.20240796
Fatimah M. Budair
From the Department of Dermatology (Budair, Al-akloby) and from the Department of Pathology (Alsayyah), King Fahd University Hospital, Alkhobar, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Kingdom of Saudi Arabia
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Ahmed A. Alsayyah
From the Department of Dermatology (Budair, Al-akloby) and from the Department of Pathology (Alsayyah), King Fahd University Hospital, Alkhobar, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Kingdom of Saudi Arabia
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Omar M. Alakloby
From the Department of Dermatology (Budair, Al-akloby) and from the Department of Pathology (Alsayyah), King Fahd University Hospital, Alkhobar, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Kingdom of Saudi Arabia
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References

  1. 1.↵
    1. Hossain C,
    2. Jennings T,
    3. Duffy R,
    4. Knoblauch K,
    5. Gochoco A,
    6. Chervoneva I, et al.
    The histological prevalence and clinical implications of folliculotropism and syringotropism in mycosis fungoides. Chin Clin Oncol 2019; 8: 6.
    OpenUrlPubMed
  2. 2.↵
    1. Willemze R,
    2. Jaffe ES,
    3. Burg G,
    4. Cerroni L,
    5. Berti E,
    6. Swerdlow SH, et al.
    WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768–3785.
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    1. Wilcox RA
    . Cutaneous T-cell lymphoma: 2017 update on diagnosis, risk-stratification, and management. Am J Hematol 2017; 92: 1085–1102.
    OpenUrlPubMed
  4. 4.↵
    1. Quaglino P,
    2. Pimpinelli N,
    3. Berti E,
    4. Calzavara-Pinton P,
    5. Alfonso Lombardo G,
    6. Rupoli S, et al.
    Time course, clinical pathways, and long-term hazards risk trends of disease progression in patients with classic mycosis fungoides: a multicenter, retrospective follow-up study from the Italian Group of Cutaneous Lymphomas. Cancer 2012; 118: 5830–5839.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Pimpinelli N,
    2. Olsen EA,
    3. Santucci M,
    4. Vonderheid E,
    5. Haeffner AC,
    6. Stevens S, et al.
    Defining early mycosis fungoides. J Am Acad Dermatol 2005; 53: 1053–1063.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Burg G,
    2. Dummer R,
    3. Nestle FO,
    4. Doebbeling U,
    5. Haeffner A
    . Cutaneous lymphomas consist of a spectrum of nosologically different entities including mycosis fungoides and small plaque parapsoriasis. Arch Dermatol 1996; 132: 567–572.
    OpenUrlCrossRefPubMedWeb of Science
  7. 7.↵
    1. Keehn CA,
    2. Belongie IP,
    3. Shistik G,
    4. Fenske NA,
    5. Glass LF
    . The diagnosis, staging, and treatment options for mycosis fungoides. Cancer Control 2007; 14: 102–111.
    OpenUrlPubMed
  8. 8.↵
    1. Vaidya T,
    2. Badri T
    ; 2024. Mycosis fungoides. Stat [Internet]. In: Treasure Island (FL): StatPearls Publishing; 2024 January.
  9. 9.
    1. Scarisbrick JJ,
    2. Quaglino P,
    3. Prince HM,
    4. Papadavid E,
    5. Hodak E,
    6. Bagot M, et al.
    The PROCLIPI international registry of early-stage mycosis fungoides identifies substantial diagnostic delay in most patients. Br J Dermatol 2019; 181: 350–357.
    OpenUrlPubMed
  10. 10.↵
    1. Tebeică T,
    2. Andrei R,
    3. Zurac S,
    4. Stăniceanu F
    . Practical aspects regarding the histopathological diagnosis of early mycosis fungoides. Rom J Intern Med 2016; 54: 3–10.
    OpenUrlPubMed
  11. 11.↵
    1. Murphy M,
    2. Fullen D,
    3. Carlson JA
    . Low CD7 expression in benign and malignant cutaneous lymphocytic infiltrates: experience with an antibody reactive with paraffin-embedded tissue. Am J Dermatopathol 2002; 24: 6–16.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Morgan SM,
    2. Hodges E,
    3. Mitchell TJ,
    4. Harris S,
    5. Whittaker SJ,
    6. Smith JL
    . Molecular analysis of T-cell receptor beta genes in cutaneous T-cell lymphoma reveals Jbeta1 bias. J Invest Dermatol 2006; 126: 1893–1899.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Zackheim HS,
    2. McCalmont TH
    . Mycosis fungoides: the great imitator. J Am Acad Dermatol 2002; 47: 914–918.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. van Doorn R,
    2. Van Haselen CW,
    3. van Voorst Vader PC,
    4. Geerts ML,
    5. Heule F,
    6. de Rie M, et al.
    Mycosis fungoides: disease evolution and prognosis of 309 Dutch patients. Arch Dermatol 2000; 136: 504–510.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Arafah M,
    2. Zaidi SN,
    3. Kfoury HK,
    4. Al Rikabi A,
    5. Al Ghamdi K
    . The histological spectrum of early mycosis fungoides: a study of 58 Saudi Arab patients. Oman Med J 2012; 27: 134–139.
    OpenUrlPubMed
  16. 16.↵
    1. Smoller BR,
    2. Bishop K,
    3. Glusac E,
    4. Kim YH,
    5. Hendrickson M
    . Reassessment of histological parameters in the diagnosis of mycosis fungoiides. Am J Surg Pathol 1995; 19: 1423–1430.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Fischer AH,
    2. Jacobson KA,
    3. Rose J,
    4. Zeller R
    . Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc 2008; 2008: pdb.prot4986.
  18. 18.↵
    1. Fung MA.
    2. Fung Ma
    . Epidermotropism’ vs. ‘exocytosis’ of lymphocytes 101: definition of terms. J Cutan Pathol 2010; 37: 525–529.
    OpenUrlPubMed
  19. 19.↵
    1. Yeh YA,
    2. Hudson AR,
    3. Prieto VG,
    4. Shea CR,
    5. Smoller BR
    . Reassessment of lymphocytic atypia in the Diagnosis of Mycosis Fungoides. Mod Pathol 2001; 14: 285–288.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Jang MS,
    2. Kang DY,
    3. Jong Bin Park,
    4. Kang JS,
    5. Kim ST,
    6. Suh KS
    . Comment on “Pseudopautrier’s abscess”. Ann Dermatol 2012; 24: 376–379.
    OpenUrlPubMed
  21. 21.↵
    1. Yamashita T,
    2. Abbade LPF,
    3. Marques MEA,
    4. Marques SA
    . Mycosis fungoides and Sézary syndrome: clinical, histopathological and immunohistochemical review and update. An Bras Dermatol 2012; 87: 817–828; quiz 829-830.
    OpenUrlPubMed
  22. 22.↵
    1. Kounelis S,
    2. Kapranos N,
    3. Malamos N,
    4. Kouri-Bairaktari E
    . Evaluation of HER2 gene status in breast cancer by chromogenic in situ hybridization: comparison with immunohistochemistry. Anticancer Res 2005; 25: 939–946.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Kelati A,
    2. Gallouj S,
    3. Tahiri L,
    4. Harmouche T,
    5. Mernissi FZ
    . Defining the mimics and clinico-histological diagnosis criteria for mycosis fungoides to minimize misdiagnosis. Int J Womens Dermatol 2017; 3: 100–106.
    OpenUrlPubMed
  24. 24.↵
    1. Skov AG,
    2. Gniadecki R
    . Delay in the histopathologic diagnosis of mycosis fungoides. Acta Derm Venereol 2015; 95: 472–475.
    OpenUrlPubMed
  25. 25.↵
    1. Vandergriff T,
    2. Nezafati KA,
    3. Susa J,
    4. Karai L,
    5. Sanguinetti A,
    6. Hynan LS, et al.
    Defining early mycosis fungoides: validation of a diagnostic algorithm proposed by the International Society for Cutaneous Lymphomas. J Cutan Pathol 2015; 42: 318–328.
    OpenUrlPubMed
  26. 26.↵
    1. Sant M,
    2. Allemani C,
    3. Tereanu C,
    4. De Angelis R,
    5. Capocaccia R,
    6. Visser O, et al.
    Incidence of hematologic malignancies in Europe by morphologic subtype: results of the haemacare project. Blood 2010; 116: 3724–3734.
    OpenUrlAbstract/FREE Full Text
  27. 27.↵
    1. Bradford PT,
    2. Devesa SS,
    3. Anderson WF,
    4. Toro JR
    . Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. Blood 2009; 113: 5064–5073.
    OpenUrlAbstract/FREE Full Text
  28. 28.↵
    1. Binamer Y
    . Cutaneous T-cell lymphoma in Saudi Arabia: retrospective single-center review. Ann Saudi Med 2017; 37: 212–215.
    OpenUrlPubMed
  29. 29.
    1. AlGhamdi KM,
    2. Arafah MM,
    3. Al-Mubarak LA,
    4. Khachemoune A,
    5. Al-Saif FM
    . Profile of mycosis fungoides in 43 Saudi patients. Ann Saudi Med 2012; 32: 283–287.
    OpenUrlPubMedWeb of Science
  30. 30.↵
    1. Cai ZR,
    2. Chen ML,
    3. Weinstock MA,
    4. Kim YH,
    5. Novoa RA,
    6. Linos E
    . Incidence trends of primary cutaneous T-cell lymphoma in the US from 2000 to 2018: a SEER population data analysis. JAMA Oncol 2022; 8: 1690–1692.
    OpenUrlPubMed
  31. 31.↵
    1. Massone C,
    2. Kodama K,
    3. Kerl H,
    4. Cerroni L
    . Histopathologic features of early (patch) lesions of mycosis fungoides: a morphologic study on 745 biopsy specimens from 427 patients. Am J Surg Pathol 2005; 29: 550–560.
    OpenUrlCrossRefPubMedWeb of Science
  32. 32.↵
    1. Shamim H,
    2. Johnson EF,
    3. Gibson LE,
    4. Comfere N
    . Mycosis fungoides with spongiosis: a potential diagnostic pitfall. J Cutan Pathol 2019; 46: 645–652.
    OpenUrlPubMed
  33. 33.↵
    1. Jawed SI,
    2. Myskowski PL,
    3. Horwitz S,
    4. Moskowitz A,
    5. Querfeld C
    . Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers. J Am Acad Dermatol 2014; 70: 205.e1–16; quiz 221–222.
    OpenUrlCrossRef
  34. 34.↵
    1. Shapiro PE,
    2. Pinto FJ
    . The histologic spectrum of mycosis fungoides/Sézary syndrome (cutaneous T-cell lymphoma). A review of 222 biopsies, including newly described patterns and the earliest pathologic changes. Am J Surg Pathol 1994; 18: 645–667.
    OpenUrlCrossRefPubMedWeb of Science
  35. 35.↵
    1. Furlan FC,
    2. Sanches JA
    . Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology. An Bras Dermatol 2013; 88: 954–960.
    OpenUrlCrossRefPubMed
  36. 36.
    1. Ito A,
    2. Sugita K,
    3. Ikeda A,
    4. Yamamoto O
    . CD4/CD8 Double-negative mycosis fungoides: a case report and literature review. Yonago Acta Med 2019; 62: 153–158.
    OpenUrlPubMed
  37. 37.↵
    1. Schachter O,
    2. Tabibian-Keissar H,
    3. Debby A,
    4. Segal O,
    5. Baum S,
    6. Barzilai A
    . Evaluation of the polymerase chain reaction-based T-cell receptor β clonality test in the diagnosis of early mycosis fungoides. J Am Acad Dermatol 2020; 83: 1400–1405.
    OpenUrlPubMed
  38. 38.↵
    1. Sari Aslani F,
    2. Naseri M,
    3. Boub R
    . CD7 expression in differentiating mycosis fungoides from benign cutaneous lymphocytic infiltrates. Iran J Med Sci 2008; 33: 144–149.
    OpenUrl
  39. 39.↵
    1. Miyagaki T
    . Diagnosis of early mycosis fungoides. Diagnostics (Basel) 2021; 11: 1721.
    OpenUrlPubMed
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Differentiating mycosis fungoides lesions from their mimickers clinically and histologically
Fatimah M. Budair, Ahmed A. Alsayyah, Omar M. Alakloby
Saudi Medical Journal Dec 2024, 45 (12) 1355-1367; DOI: 10.15537/smj.2024.45.12.20240796

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Differentiating mycosis fungoides lesions from their mimickers clinically and histologically
Fatimah M. Budair, Ahmed A. Alsayyah, Omar M. Alakloby
Saudi Medical Journal Dec 2024, 45 (12) 1355-1367; DOI: 10.15537/smj.2024.45.12.20240796
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