Specific association of MTHFD1 expressions with small cell lung cancer development and chemoradiotherapy outcome

References

1. 1.↵
   1. Bade BC,
   2. Dela Cruz CS

   . Lung cancer 2020: epidemiology, etiology, and prevention. Clin Chest Med 2020; 41: 1-24.

   OpenUrlCrossRefPubMed
2. 2.↵
   1. Wu F,
   2. Wang L,
   3. Zhou C

   . Lung cancer in China: current and prospect. Curr Opin Oncol 2021; 33: 40-46.

   OpenUrlCrossRef
3. 3.↵
   1. Tseng JS,
   2. Chiang CJ,
   3. Chen KC,
   4. Zheng ZR,
   5. Yang TY,
   6. Lee WC, et al.

   Association of smoking with patient characteristics and outcomes in small cell lung carcinoma, 2011-2018. JAMA Netw Open 2022; 5: e224830.

   OpenUrl
4. 4.↵
   1. Larsson SC,
   2. Burgess S

   . Appraising the causal role of smoking in multiple diseases: a systematic review and meta-analysis of Mendelian randomization studies. EBioMedicine 2022; 82: 104154.

   OpenUrl
5. 5.↵
   1. Baumeister SE,
   2. Baurecht H,
   3. Nolde M,
   4. Alayash Z,
   5. Gläser S,
   6. Johansson M, et al.

   Cannabis use, pulmonary function, and lung cancer susceptibility: a Mendelian randomization study. J Thorac Oncol 2021; 16: 1127-1135.

   OpenUrl
6. 6.↵
   1. Dekhne AS,
   2. Hou Z,
   3. Gangjee A,
   4. Matherly LH

   . Therapeutic targeting of mitochondrial one-carbon metabolism in cancer. Mol Cancer Ther 2020; 19: 2245-2255.

   OpenUrlAbstract/FREE Full Text
7. 7.↵
   1. Yu H,
   2. Wang H,
   3. Xu HR,
   4. Zhang YC,
   5. Yu XB,
   6. Wu MC, et al.

   Overexpression of MTHFD1 in hepatocellular carcinoma predicts poorer survival and recurrence. Future Oncol 2019; 15: 1771-1780.

   OpenUrl
8. 8.
   1. Zheng Y,
   2. Zhu L,
   3. Qin ZY,
   4. Guo Y,
   5. Wang S,
   6. Xue M, et al.

   Modulation of cellular metabolism by protein crotonylation regulates pancreatic cancer progression. Cell Rep 2023; 42: 112666.

   OpenUrl
9. 9.↵
   1. Guan J,
   2. Li M,
   3. Wang Y,
   4. Zhang Y,
   5. Que Y,
   6. Lu S, et al.

   MTHFD1 regulates the NADPH redox homeostasis in MYCN-amplified neuroblastoma. Cell Death Dis 2024; 15: 124.

   OpenUrl
10. 10.↵
    1. Zhou Y,
    2. Zhou B,
    3. Pache L,
    4. Chang M,
    5. Khodabakhshi AH,
    6. Tanaseichuk O, et al.

    Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 2019; 10: 1523.

    OpenUrlCrossRefPubMed
11. 11.↵
    1. Khaki AA,
    2. Tanoomand A,
    3. Hajibemani A,
    4. Abouhamzeh B

    . Detection of polymorphisms in MTHFD1 G1958A and its possible association with idiopathic male infertility. Urol J 2019; 16: 586-591.

    OpenUrl
12. 12.↵
    1. Seijo LM,
    2. Peled N,
    3. Ajona D,
    4. Boeri M,
    5. Field JK,
    6. Sozzi G, et al.

    Biomarkers in lung cancer screening: achievements, promises, and challenges. J Thorac Oncol 2019; 14: 343-357.

    OpenUrlCrossRef
13. 13.↵
    1. Chemi F,
    2. Pearce SP,
    3. Clipson A,
    4. Hill SM,
    5. Conway AM,
    6. Richardson SA, et al.

    cfDNA methylome profiling for detection and subtyping of small cell lung cancers. Nat Cancer 2022; 3: 1260-1270.

    OpenUrl
14. 14.↵
    1. Zhang P,
    2. Pei S,
    3. Gong Z,
    4. Feng Y,
    5. Zhang X,
    6. Yang F, et al.

    By integrating single-cell RNA-seq and bulk RNA-seq in sphingolipid metabolism, CACYBP was identified as a potential therapeutic target in lung adenocarcinoma. Front Immunol 2023; 14: 1115272.

    OpenUrl
15. 15.↵
    1. C L, S P,
    2. Kashyap AH,
    3. Rahaman A,
    4. Niranjan S,
    5. Niranjan V.

    Novel biomarker prediction for lung cancer using random forest classifiers. Cancer Inform 2023; 22: 11769351231167992.
16. 16.↵
    1. Zhang Y,
    2. Chen Q,
    3. Huang T,
    4. Zhu D,
    5. Lu Y

    . Bioinformatics-based screening of key genes for transformation of tyrosine kinase inhibitor-resistant lung adenocarcinoma to small cell lung cancer. Front Med (Lausanne) 2023; 10: 1203461.

    OpenUrl
17. 17.↵
    1. Zhang X,
    2. Yang L,
    3. Huang B,
    4. Yin J,
    5. Wei Y

    . Identification and validation of cyclin A2 and cyclin E2 as potential biomarkers in small cell lung cancer. Oncol Res Treat 2023; 46: 246-258.

    OpenUrl
18. 18.↵
    1. Liu M,
    2. Xu K,
    3. Saaoud F,
    4. Shao Y,
    5. Zhang R,
    6. Lu Y, et al.

    29 m⁶A-RNA methylation (epitranscriptomic) regulators are regulated in 41 diseases including atherosclerosis and tumors potentially via ROS regulation - 102 transcriptomic dataset analyses. J Immunol Res 2022; 2022: 1433323.

    OpenUrl
19. 19.↵
    1. Meng Q,
    2. Lu YX,
    3. Wei C,
    4. Wang ZX,
    5. Lin JF,
    6. Liao K, et al.

    Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis. Oncogene 2022; 41: 3912-3924.

    OpenUrl
20. 20.↵
    1. Ponomaryova AA,
    2. Schegoleva AA,
    3. Gervas PA,
    4. Pancova OV,
    5. Gerashchenko TS,
    6. Zarubin AA, et al.

    DNA methylome analysis reveals potential alterations contributing to the progression of bronchial hyperplasia. Mol Biol Rep 2023; 50: 7941-7947.

    OpenUrl
21. 21.↵
    1. Chen Y,
    2. Liu X,
    3. Li Y,
    4. Quan C,
    5. Zheng L,
    6. Huang K

    . Lung cancer therapy targeting histone methylation: opportunities and challenges. Comput Struct Biotechnol J 2018; 16: 211-223.

    OpenUrlCrossRef