Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss

Nihal Çallıoğlu, Derya K. Gül, İlke Ö. Arslan, İpek Geyikoğlu and Ergül Demirçivi
Saudi Medical Journal August 2024, 45 (8) 808-813; DOI: https://doi.org/10.15537/smj.2024.45.8.20240404
Nihal Çallıoğlu
From the Department of Perinatology (Çallıoğlu); from the Department of Obstetrics and Gynecology (Geyikoğlu), Başakşehir Çam and Sakura City Hospital, from the Department of Obstetrics and Gynecology (Gül), Medipol University School of Medicine Health, from the Department of Obstetrıc and Gynecology (Demirçivi), Clinic of Obstetrics and Gynecology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, and from the Department of Obstetrics and Gynecology (Arslan), Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nihal Çallıoğlu
  • For correspondence: [email protected]
Derya K. Gül
From the Department of Perinatology (Çallıoğlu); from the Department of Obstetrics and Gynecology (Geyikoğlu), Başakşehir Çam and Sakura City Hospital, from the Department of Obstetrics and Gynecology (Gül), Medipol University School of Medicine Health, from the Department of Obstetrıc and Gynecology (Demirçivi), Clinic of Obstetrics and Gynecology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, and from the Department of Obstetrics and Gynecology (Arslan), Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
İlke Ö. Arslan
From the Department of Perinatology (Çallıoğlu); from the Department of Obstetrics and Gynecology (Geyikoğlu), Başakşehir Çam and Sakura City Hospital, from the Department of Obstetrics and Gynecology (Gül), Medipol University School of Medicine Health, from the Department of Obstetrıc and Gynecology (Demirçivi), Clinic of Obstetrics and Gynecology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, and from the Department of Obstetrics and Gynecology (Arslan), Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
İpek Geyikoğlu
From the Department of Perinatology (Çallıoğlu); from the Department of Obstetrics and Gynecology (Geyikoğlu), Başakşehir Çam and Sakura City Hospital, from the Department of Obstetrics and Gynecology (Gül), Medipol University School of Medicine Health, from the Department of Obstetrıc and Gynecology (Demirçivi), Clinic of Obstetrics and Gynecology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, and from the Department of Obstetrics and Gynecology (Arslan), Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ergül Demirçivi
From the Department of Perinatology (Çallıoğlu); from the Department of Obstetrics and Gynecology (Geyikoğlu), Başakşehir Çam and Sakura City Hospital, from the Department of Obstetrics and Gynecology (Gül), Medipol University School of Medicine Health, from the Department of Obstetrıc and Gynecology (Demirçivi), Clinic of Obstetrics and Gynecology, Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, and from the Department of Obstetrics and Gynecology (Arslan), Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    NICE. Ectopic pregnancy and miscarriage: diagnosis and initial management. [Updated 2023; 2024 May 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/31393678/
  2. 2.↵
    1. Magnus MC,
    2. Wilcox AJ,
    3. Morken NH,
    4. Weinberg CR,
    5. Håberg SE
    . Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study. BMJ 2019; 364: l869.
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    1. Kolte AM,
    2. Bernardi LA,
    3. Christiansen OB,
    4. Quenby S,
    5. Farquharson RG,
    6. Goddijn M, et al.
    Terminology for pregnancy loss prior to viability: a consensus statement from the ESHRE early pregnancy special interest group. Hum Reprod 2015; 30: 495-498.
    OpenUrlCrossRefPubMed
  4. 4.↵
    NICE. Ectopic pregnancy and miscarriage: medical management of miscarriage. [Updated 2023; 2024 May 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/31393678/
  5. 5.↵
    1. Mouri M,
    2. Hall H,
    3. Rupp TJ
    . Threatened miscarriage. [Updated 2024; 2024 April 25]. Available from: https://pubmed.ncbi.nlm.nih.gov/28613498/
  6. 6.↵
    1. Calleja-Agius J,
    2. Muttukrishna S,
    3. Pizzey AR,
    4. Jauniaux E
    . Pro- and anti-inflammatory cytokines in threatened miscarriages. Am J Obstet Gynecol 2011; 205: 83.
    OpenUrlCrossRef
  7. 7.↵
    1. Calleja-Agius J,
    2. Jauniaux E,
    3. Pizzey AR,
    4. Muttukrishna S
    . Investigation of systemic inflammatory response in first trimester pregnancy failure. Hum Reprod 2012; 27: 349-357.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. Biyik I,
    2. Albayrak M,
    3. Keskin F
    . Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in missed abortion. Rev Bras Ginecol Obstet 2020; 42: 235-239.
    OpenUrl
  9. 9.
    1. Liu D,
    2. Huang X,
    3. Xu Z,
    4. Chen M,
    5. Wu M
    . Predictive value of NLR and PLR in missed miscarriage. J Clin Lab Anal 2022; 36: e24250.
    OpenUrl
  10. 10.↵
    1. Yazdizadeh M,
    2. Hivehchi N,
    3. Ghaemi M,
    4. Azizi S,
    5. Saeedzarandi M,
    6. Afrooz N, et al.
    Platelet to lymphocyte and neutrophil to lymphocyte ratio in the first trimester of pregnancy, are they useful for predicting spontaneous miscarriage? A case-control study. Int J Reprod Biomed 2023; 21: 463-470.
    OpenUrl
  11. 11.↵
    1. Biyik M,
    2. Biyik Z,
    3. Asil M,
    4. Keskin M
    . Systemic inflammation response index and systemic immune inflammation index are associated with clinical outcomes in patients with acute pancreatitis? J Invest Surg 2022; 35: 1613-1620.
    OpenUrl
  12. 12.
    1. Dziedzic EA,
    2. Gąsior JS,
    3. Tuzimek A,
    4. Paleczny J,
    5. Junka A,
    6. Dąbrowski M, et al.
    Investigation of the associations of novel inflammatory biomarkers-systemic inflammatory index (SII) and systemic inflammatory response index (SIRI)-with the severity of coronary artery disease and acute coronary syndrome occurrence. Int J Mol Sci 2022; 23: 9553.
    OpenUrl
  13. 13.↵
    1. Atasever Akkas E,
    2. Erdis E,
    3. Yucel B
    . Prognostic value of the systemic immune-inflammation index, systemic inflammation response index, and prognostic nutritional index in head and neck cancer. Eur Arch Otorhinolaryngol 2023; 280: 3821-3830.
    OpenUrl
  14. 14.↵
    1. Yakıştıran B,
    2. Tanacan A,
    3. Altınboğa O,
    4. Yücel A
    . Can derived neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and delta neutrophil index predict spontaneous abortion? Z Geburtshilfe Neonatol 2021; 225: 418-422.
    OpenUrl
  15. 15.↵
    1. Oğlak SC,
    2. Aydın MF
    . Are neutrophil to lymphocyte ratio and platelet to lymphocyte ratio clinically useful for the prediction of early pregnancy loss? Ginekol Pol 2020; 91: 524-527.
    OpenUrlCrossRef
  16. 16.↵
    1. Bruand M,
    2. Barras D,
    3. Mina M,
    4. Ghisoni E,
    5. Morotti M,
    6. Lanitis E, et al.
    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING. Cell Rep 2021; 36: 109412.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Comins-Boo A,
    2. Valdeolivas L,
    3. Pérez-Pla F,
    4. Cristóbal I,
    5. Subhi-Issa N,
    6. Domínguez-Soto Á, et al.
    Immunophenotyping of peripheral blood monocytes could help identify a baseline pro-inflammatory profile in women with recurrent reproductive failure. J Reprod Immunol 2022; 154: 103735.
    OpenUrl
  18. 18.↵
    1. Abu-Raya B,
    2. Michalski C,
    3. Sadarangani M,
    4. Lavoie PM
    . Maternal immunological adaptation during normal pregnancy. Front Immunol 2020; 11: 575197.
    OpenUrl
  19. 19.↵
    1. Ata N,
    2. Kulhan M,
    3. Kulhan NG,
    4. Turkler C
    . Can neutrophil-lymphocyte and platelet-lymphocyte ratios predict threatened abortion and early pregnancy loss? Ginekol Pol 2020; 91: 210-215.
    OpenUrl
  20. 20.↵
    1. Hua X,
    2. Long ZQ,
    3. Huang X,
    4. Deng JP,
    5. Wen W,
    6. He ZY, et al.
    The preoperative systemic inflammation response index (SIRI) independently predicts survival in postmenopausal women with breast cancer. Curr Probl Cancer 2020; 44: 100560.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Xu L,
    2. Yu S,
    3. Zhuang L,
    4. Wang P,
    5. Shen Y,
    6. Lin J, et al.
    Systemic inflammation response index (SIRI) predicts prognosis in hepatocellular carcinoma patients. Oncotarget 2017; 8: 34954-34960.
    OpenUrl
  22. 22.↵
    1. Seyhanli Z,
    2. Bayraktar B,
    3. Baysoz OB,
    4. Karabay G,
    5. Sucu ST,
    6. Ulusoy CO, et al.
    The role of first trimester serum inflammatory indexes (NLR, PLR, MLR, SII, SIRI, and PIV) and the β-hCG to PAPP-A ratio in predicting preeclampsia. J Reprod Immunol 2024; 162: 104190.
    OpenUrl
  23. 23.↵
    1. Sahin R,
    2. Tanacan A,
    3. Serbetci H,
    4. Agaoglu Z,
    5. Karagoz B,
    6. Haksever M, et al.
    The role of first-trimester NLR (neutrophil to lymphocyte ratio), systemic immune-inflammation index (SII), and, systemic immune-response index (SIRI) in the prediction of composite adverse outcomes in pregnant women with systemic lupus erythematosus. J Reprod Immunol 2023; 158: 103978.
    OpenUrl
  24. 24.↵
    1. Hu B,
    2. Yang XR,
    3. Xu Y,
    4. Sun YF,
    5. Sun C,
    6. Guo W, et al.
    Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 2014; 20: 6212-6222.
    OpenUrlAbstract/FREE Full Text
  25. 25.↵
    1. Liu X,
    2. Guan G,
    3. Cui X,
    4. Liu Y,
    5. Liu Y,
    6. Luo F
    . Systemic immune-inflammation index (SII) can be an early indicator for predicting the severity of acute pancreatitis: a retrospective study. Int J Gen Med 2021; 14: 9483-9489.
    OpenUrl
  26. 26.↵
    1. Ji P,
    2. He J
    . Prognostic value of pretreatment systemic immune-inflammation index in patients with endometrial cancer: a meta-analysis. Biomark Med 2024; 18: 345-356.
    OpenUrl
  27. 27.↵
    1. Turgut E,
    2. Yildirim M,
    3. Sakcak B,
    4. Ayhan SG,
    5. Tekin OM,
    6. Sahin D
    . Predicting miscarriage using systemic immune-inflammation index. J Obstet Gynaecol Res 2022; 48: 587-592.
    OpenUrl
  28. 28.↵
    1. Wincup C,
    2. Parnell C,
    3. Cleanthous S,
    4. Tejera Segura B,
    5. Nguyen MH,
    6. Bryant K, et al.
    Red cell distribution width correlates with fatigue levels in a diverse group of patients with systemic lupus erythematosus irrespective of anaemia status. Clin Exp Rheumatol 2019; 37: 852-854.
    OpenUrlPubMed
  29. 29.↵
    1. Jagroop IA,
    2. Clatworthy I,
    3. Lewin J,
    4. Mikhailidis DP
    . Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy. Platelets 2000; 11: 28-32.
    OpenUrlCrossRefPubMedWeb of Science
  30. 30.↵
    1. Alonso A,
    2. Soto I,
    3. Urgellés MF,
    4. Corte JR,
    5. Rodríguez MJ,
    6. Pinto CR
    . Acquired and inherited thrombophilia in women with unexplained fetal losses. Am J Obstet Gynecol 2002; 187: 1337-1342.
    OpenUrlCrossRefPubMedWeb of Science
  31. 31.↵
    1. Aynıoglu O,
    2. Isık H,
    3. Sahbaz A,
    4. Harma MI,
    5. Isık M,
    6. Kokturk F
    . Can plateletcrit be a marker for recurrent pregnancy loss? Clin Appl Thromb Hemost 2016; 22: 447-452.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 45 (8)
Saudi Medical Journal
Vol. 45, Issue 8
1 Aug 2024
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss
Nihal Çallıoğlu, Derya K. Gül, İlke Ö. Arslan, İpek Geyikoğlu, Ergül Demirçivi
Saudi Medical Journal Aug 2024, 45 (8) 808-813; DOI: 10.15537/smj.2024.45.8.20240404

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss
Nihal Çallıoğlu, Derya K. Gül, İlke Ö. Arslan, İpek Geyikoğlu, Ergül Demirçivi
Saudi Medical Journal Aug 2024, 45 (8) 808-813; DOI: 10.15537/smj.2024.45.8.20240404
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Psychological stress and its association with bronchial asthma in Saudi Arabia
  • The factors affecting comfort and the comfort levels of patients hospitalized in the coronary intensive care unit
  • Exploring communication challenges with children and parents among pharmacists in Saudi Arabia
Show more Original Article

Similar Articles

Keywords

  • early pregnancy loss
  • systemic immune-inflammatory index
  • systemic inflammatory response index
  • mean platelet volume
  • inflammatory biomarkers

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire