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Case ReportCase Report
Open Access

Obstructive uropathy in STAT 3 hyper immunoglobulin E syndrome

A 5 year old Middle Eastern boy

Esraa M. Bukhari and Ashwag A. Alsaidalani
Saudi Medical Journal August 2024, 45 (8) 851-856; DOI: https://doi.org/10.15537/smj.2024.45.8.20240123
Esraa M. Bukhari
From the Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
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Ashwag A. Alsaidalani
From the Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
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  • Figure 1
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    Figure 1

    - Enhanced CT of the chest. a) Sagittal reformats in bone window showing a rib fracture (arrow). b) Coronal reformats showing right upper lobe pneumatocele (asterisk).

  • Figure 2
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    Figure 2

    - Coronal enhanced CT abdomen and pelvis showing multiple walled-off collections (asterisks) displacing the thickened urinary bladder (circle) and compressing the right iliac vein (small arrows). Multiple bilateral inguinal enlarged lymph nodes (bold arrows), one showing central necrosis (arrowheads). These collections were compressing the ureters causing bilateral upstream pelvicalyceal dilatation (not shown).

  • Figure 3
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    Figure 3

    - The timeline from the initial patient presentation until the discharge.

  • Appendix 1
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    Appendix 1

    - Hyper immunoglobulin E syndrome scoring system/Grimbacher scale.

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    Table 1

    - Laboratory results.

    VariablesComplete blood countReference range
    WBC15.12 k/uL4-11 k/uL
    neutrophils8.27 k/uL1-8.5 k/uL
    lymphocytes4.83 k/uL2-8 k/uL
    eosinophils1.29 k/uL0.2-0.8 k/uL
    Hemoglobin8.5 k/uL10.2-15.2 k/uL
    Hematocrit29.1 k/uL34-48 k/uL
    Platelet272 k/uL150-450 k/uL
    CRP22.7 mg/L0-3 mg/L
    Urea and electrolytes
    Urea19.6 mmol/L3.2-8.2 mmol/L
    creatinine309 µmol/L 
    potassium6.4 mmol/L3.5-5.1 mmol/L
    sodium134 mmol/L136-145 mmol/L
    Albumin42 g/L40.2-47.6 g/L
    Serology
    HIVNegative 
    Immunoglobulins
    IgA1.01 g/L0.4-2 g/L
    IgG11.9 g/L4.9-16.1 g/L
    IgM1.27 g/L0.5-2 g/L
    IgE14100 IU/ml150-1000 IU/ml

    Methicillin-resistant Staphylococcus aureus nasal swab, positive; tuberculosis quantiferone, negative.

    WBC: white blood cells, CRP: C-reactive protein, HIV: human immunodeficiency virus, IgA: immunoglobulin A, IgG: immunoglobulin G, IgM: immunoglobulin M, IgE: immunoglobulin E

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    Saudi Medical Journal: 45 (8)
    Saudi Medical Journal
    Vol. 45, Issue 8
    1 Aug 2024
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    Obstructive uropathy in STAT 3 hyper immunoglobulin E syndrome
    Esraa M. Bukhari, Ashwag A. Alsaidalani
    Saudi Medical Journal Aug 2024, 45 (8) 851-856; DOI: 10.15537/smj.2024.45.8.20240123

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    Obstructive uropathy in STAT 3 hyper immunoglobulin E syndrome
    Esraa M. Bukhari, Ashwag A. Alsaidalani
    Saudi Medical Journal Aug 2024, 45 (8) 851-856; DOI: 10.15537/smj.2024.45.8.20240123
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    Keywords

    • STAT 3
    • HIES
    • AKI
    • pelvic abscess
    • eczema

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