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Research ArticleOriginal Article
Open Access

Prevalence and clinical considerations of Y chromosome microdeletions in azoospermic and oligozoopsermic infertile men from Al Madinah Al Munawarah, Saudi Arabia

Monis B. Shamsi, Rima Dada, Reham M. Balahmar, Dimah Zaytuni, Ghadeer Alharbi, Syed N. Imam, Emad Rajih, Muhammad Latif and Saif Ahmad
Saudi Medical Journal February 2025, 46 (2) 124-130; DOI: https://doi.org/10.15537/smj.2025.46.2.20240764
Monis B. Shamsi
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
MS, PhD
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  • ORCID record for Monis B. Shamsi
  • For correspondence: [email protected]
Rima Dada
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
MD, PhD
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Reham M. Balahmar
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
MS, PhD
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Dimah Zaytuni
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
BS
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Ghadeer Alharbi
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
BS
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Syed N. Imam
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
MD
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Emad Rajih
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
MBBS, MD
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Muhammad Latif
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
MS, PhD
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Saif Ahmad
From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
MS, PhD
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Article Information

vol. 46 no. 2 124-130
DOI 
https://doi.org/10.15537/smj.2025.46.2.20240764
PubMed 
39933777

Published By 
Saudi Medical Journal
Online ISSN 
1658-3175
History 
  • Received September 9, 2024
  • Accepted December 26, 2024
  • Published online February 10, 2025.

Copyright & Usage 
Copyright: © Saudi Medical Journal This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

Author Information

  1. Monis B. Shamsi, MS, PhD⇑,
  2. Rima Dada, MD, PhD,
  3. Reham M. Balahmar, MS, PhD,
  4. Dimah Zaytuni, BS,
  5. Ghadeer Alharbi, BS,
  6. Syed N. Imam, MD,
  7. Emad Rajih, MBBS, MD,
  8. Muhammad Latif, MS, PhD and
  9. Saif Ahmad, MS, PhD
  1. From the Center for Genetics and Inherited Diseases (Shamsi, Balahmar, Zaytuni, Alharbi, Latif); from the Department of Basic Medical Sciences (Shamsi, Imam, Latif); from the Department of General and Specialized Surgery (Rajih), College of Medicine, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia, from the Department of Anatomy (Dada), Laboratory of Molecular Reproduction & Genetics, All India Institute of Medical Sciences, New Delhi, India, and from the Department of Translational Neuroscience (Ahmad), Barrow Neurological Institute, Phoenix, United States of America.
  1. Address correspondence and reprint request to: Dr. Monis B. Shamsi, Centre for Genetics and Inherited Diseases, Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia. E-mail: monisbilalshamsi{at}gmail.com
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Prevalence and clinical considerations of Y chromosome microdeletions in azoospermic and oligozoopsermic infertile men from Al Madinah Al Munawarah, Saudi Arabia
Monis B. Shamsi, Rima Dada, Reham M. Balahmar, Dimah Zaytuni, Ghadeer Alharbi, Syed N. Imam, Emad Rajih, Muhammad Latif, Saif Ahmad
Saudi Medical Journal Feb 2025, 46 (2) 124-130; DOI: 10.15537/smj.2025.46.2.20240764

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Prevalence and clinical considerations of Y chromosome microdeletions in azoospermic and oligozoopsermic infertile men from Al Madinah Al Munawarah, Saudi Arabia
Monis B. Shamsi, Rima Dada, Reham M. Balahmar, Dimah Zaytuni, Ghadeer Alharbi, Syed N. Imam, Emad Rajih, Muhammad Latif, Saif Ahmad
Saudi Medical Journal Feb 2025, 46 (2) 124-130; DOI: 10.15537/smj.2025.46.2.20240764
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Keywords

  • Y chromosome microdeletions
  • male infertility
  • azoospermia
  • oligozoospermia
  • STS markers

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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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