Association between factor I fibrinogen (rs6050) and factor XI plasma thromboplastin (rs4253417) genetic polymorphisms and recurrent spontaneous miscarriage in Saudi women

Article Figures & Data

Table 1

- Association of Factor I fibrinogen rs6050 C/T polymorphism with recurrent spontaneous miscarriage (RSM) in pregnant Saudi women.

Genotype	RSM pregnant		Control		Patients (RSM pregnant) vs. control
Genotype	n (%)	OR	n (%)	OR	OR	CI	X²	P-value
CC	7 (14%)	0.16	13 (26%)	0.35	0.46	0.17 to 1.28	2.23	0.14
CT	31 (62%)	1.63	14 (28%)	0.39	4.18	1.81 to 9.73	11.56	0.001
TT	12 (24%)	0.32	23 (46%)	0.85	0.38	0.16 to 0.87	5.27	0.02
Total	50		50
Alleles frequencies
C	45 (45%)	0.82	40 (40%)	0.67	1.22	0.70 to 2.15
T	55 (55%)	1.22	60 (60%)	1.5	0.81	0.46 to 1.43	0.51	0.48

CI: Confidence interval, vs: versus, a p-value of ≤0.05 determined statistical significance, OR: odds ratio, X²: Chi-square

Table 2

- Recurrent susceptibility to spontaneous miscarriage and Factor I fibrinogen rs6050 C/T polymorphism in non-pregnant Saudi women

Genotype	RSM non-pregnant		Control		Patients (non-pregnant RSM) vs. Control
Genotype	n (%)	OR	n (%)	OR	OR	CI	X²	P-value
CC	6 (12%)	0.14	5 (10%)	0.11	1.27	0.35 to 4.32	0.10	0.75
CT	34 (68%)	2.13	14 (28%)	0.39	5.46	2.32 to 12.87	15.87	0.001
TT	10 (20%)	0.25	31 (62%)	1.63	0.15	0.06 to 0.38	18.05	0.001
Total	50		50
Alleles frequencies
C	46 (46%)	0.85	24 (24%)	0.32	2.66	1.47 to 4.94
T	54 (54%)	1.17	76 (76%)	3.17	0.37	0.20 to 0.78	10.58	0.001

CI: Confidence interval, vs: versus, A p-value of ≤0.05 determined statistical significance, OR: Odds ratio, X²: Chi-square

Table 3

- Factor XI plasma thromboplastin rs4253417 C/T polymorphism in pregnant Saudi women experiencing recurrent spontaneous miscarriage.

Genotype	RSM pregnant		Control		Patients (RSM pregnant) vs. Control
Genotype	n (%)	OR	n (%)	OR	OR	CI	X²	P-value
CC	15 (30%)	0.43	13 (26%)	0.35	1.23	0.51 to 2.93	0.20	0.66
CT	8 (16%)	0.19	15 (30%)	0.43	0.44	0.17 to 1.17	2.74	0.10
TT	27 (54%)	1.17	22 (44%)	0.79	1.48	0.68 to 3.29	0.99	0.32
Total	50		50
Alleles frequencies
C	38 (38%)	0.61	41 (41%)	0.69	0.88	0.50 to 1.56
T	62 (62%)	1.63	59 (59%)	1.44	1.13	0.64 to 2.00	0.19	0.66

CI: Confidence interval, vs: versus, A p-value of ≤0.05 determined statistical significance, OR: Odds ratio, X²: Chi-square

Table 4

- Factor XI plasma thromboplastin rs4253417 C/T polymorphism in non-pregnant Saudi women with recurrent spontaneous miscarriage.

Genotype	RSM non-pregnant		Control		Patients (RSM non-pregnant) vs. Control
Genotype	n (%)	OR	n (%)	OR	OR	CI	X²	P-value
CC	22 (44%)	0.79	22 (44%)	0.79	1.00	0.45 to 2.20	0.00	0.99
CT	6 (12%)	0.14	9 (18%)	0.22	0.64	0.20 to 1.90	0.70	0.40
TT	22 (44%)	0.79	19 (38%)	0.61	1.30	0.58 to 2.85	0.37	0.54
Total	50		50
Alleles frequencies
C	50 (50%)	1.00	53 (53%)	1.13	0.88	0.51 to 1.54
T	50 (50%)	1.00	47 (47%)	0.89	1.12	0.65 to 1.96	0.18	0.67

CI: Confidence interval, vs: versus, A p-value of ≤0.05 determined statistical significance, OR: odds ratio, X²: Chi-square

Table 5

- Comparison of the mean levels of fibrinogen and plasma thromboplastin in Saudi women with recurrent spontaneous miscarriage and healthy controls.