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Research ArticleOriginal Article
Open Access

Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways

Prashant P. Bavi, Jehad A. Abubaker, Zeenath D. Jehan, Naif A. Al-Jomah, Abdul K. Siraj, Sayer R. Al-Harbi, Valerie L. Atizado, Alaa S. Abduljabbar, Samar J. Alhomoud, Luai H. Ashari, Fouad H. Al-Dayel, Shahab Uddin, Khawla S. Al-Kuraya and Nasser A. Alsanea
Saudi Medical Journal January 2008, 29 (1) 75-80;
Prashant P. Bavi
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Jehad A. Abubaker
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Zeenath D. Jehan
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Naif A. Al-Jomah
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Abdul K. Siraj
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Sayer R. Al-Harbi
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Valerie L. Atizado
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Alaa S. Abduljabbar
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Samar J. Alhomoud
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Luai H. Ashari
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Fouad H. Al-Dayel
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Shahab Uddin
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Khawla S. Al-Kuraya
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Nasser A. Alsanea
Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Abstract

OBJECTIVE: To evaluate the overall incidence of microsatellite instability (MSI), hereditary non polyposis colorectal cancer, and tumor supressor gene (TP53) mutations in Saudi colorectal carcinomas.

METHODS: We studied the MSI pathway in Saudi colorectal cancers (CRC) from 179 unselected patients using 2

MSI by polymerase chain reaction, and immunohistochemistry detection of mutL homologs 1 and mutS homologs 2 proteins. The TP53 mutations were studied by sequencing exons 5, 6, 7, and 8.

RESULTS: Of the 150 colorectal carcinomas analyzed for MSI, 16% of the tumors showed high level instability (MSI-H), 19.3% had low-level instability (MSI-L) and the remaining 64% tumors were stable. Survival of the MSI-H group was better as compared to the MSI-L or microsatellite stable group (p=0.0217). In the MSI-H group, 48% were familial MSI tumors, which could be attributable to the high incidence of consanguinity in the Saudi population. The TP53 mutations were found in 24% of the cases studied.

CONCLUSION: A high proportion of familial MSI cases and a lower incidence of TP53 mutations are some of the hallmarks of the Saudi colorectal carcinomas, which need to be explored further.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 29 (1)
Saudi Medical Journal
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Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways
Prashant P. Bavi, Jehad A. Abubaker, Zeenath D. Jehan, Naif A. Al-Jomah, Abdul K. Siraj, Sayer R. Al-Harbi, Valerie L. Atizado, Alaa S. Abduljabbar, Samar J. Alhomoud, Luai H. Ashari, Fouad H. Al-Dayel, Shahab Uddin, Khawla S. Al-Kuraya, Nasser A. Alsanea
Saudi Medical Journal Jan 2008, 29 (1) 75-80;

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Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways
Prashant P. Bavi, Jehad A. Abubaker, Zeenath D. Jehan, Naif A. Al-Jomah, Abdul K. Siraj, Sayer R. Al-Harbi, Valerie L. Atizado, Alaa S. Abduljabbar, Samar J. Alhomoud, Luai H. Ashari, Fouad H. Al-Dayel, Shahab Uddin, Khawla S. Al-Kuraya, Nasser A. Alsanea
Saudi Medical Journal Jan 2008, 29 (1) 75-80;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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