Research ArticleOriginal Article
Open Access

Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease

Chenggui Liu, Yinzhong Yang, Duanliang Peng, Linong Chen and Jun Luo
Saudi Medical Journal July 2015, 36 (7) 839-846; DOI: https://doi.org/10.15537/smj.2015.7.11453

References

  1. 1.↵
    1. Vedanthan R,
    2. Seligman B,
    3. Fuster V
    (2014) Global perspective on acute coronary syndrome: a burden on the young and poor. Circ Res 114:1959–1975.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. Ruggiero D,
    2. Paolillo S,
    3. Ratta GD,
    4. Mariniello A,
    5. Formisano T,
    6. Pellegrino AM,
    7. et al.
    (2013) [Endothelial function as a marker of pre-clinical atherosclerosis: assessment techniques and clinical implications]. Monaldi Arch Chest Dis 80:106–110, Italian.
    OpenUrlPubMed
  3. 3.↵
    1. Subbotin VM
    (2012) Neovascularization of coronary tunica intima (DIT) is the cause of coronary atherosclerosis. Lipoproteins invade coronary intima via neovascularization from adventitial vasa vasorum, but not from the arterial lumen: a hypothesis. Theor Biol Med Model 9:11.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Matsuzawa Y,
    2. Lerman A
    (2014) Endothelial dysfunction and coronary artery disease: assessment, prognosis, and treatment. Coron Artery Dis 25:713–724.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Wen J,
    2. Wen Y,
    3. Zhiliang L,
    4. Lingling C,
    5. Longxing C,
    6. Ming W,
    7. et al.
    (2013) A decrease in the percentage of circulating mDC precursors in patients with coronary heart disease: a relation to the severity and extent of coronary artery lesions? Heart Vessels 28:135–142.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Antoniades C,
    2. Antonopoulos AS,
    3. Tousoulis D,
    4. Marinou K,
    5. Stefanadis C
    (2009) Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J 30:6–15.
    OpenUrlCrossRefPubMedWeb of Science
  7. 7.↵
    1. Zeng R,
    2. Xu CH,
    3. Xu YN,
    4. Wang YL,
    5. Wang M
    (2015) The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis. Public Health Nutr 18:1514–1521.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Liu Y,
    2. Tian T,
    3. Zhang H,
    4. Gao L,
    5. Zhou X
    (2014) The effect of homocysteine-lowering therapy with folic acid on flow-mediated vasodilation in patients with coronary artery disease: a meta-analysis of randomized controlled trials. Atherosclerosis 235:31–35.
    OpenUrl
  9. 9.↵
    1. Mahalle N,
    2. Kulkarni MV,
    3. Garg MK,
    4. Naik SS
    (2013) Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease. J Cardiol 61:289–294.
    OpenUrl
  10. 10.↵
    1. Wang HJ,
    2. Wang ZH,
    3. Yu WT,
    4. Zhang B,
    5. Zhai FY
    (2008) [Changes of waist circumference distribution and the prevalence of abdominal adiposity among Chinese adults from 1993 to 2006]. Zhonghua Liu Xing Bing Xue Za Zhi 29:953–958, Chinese.
    OpenUrlPubMed
  11. 11.↵
    1. Eren E,
    2. Ellidag HY,
    3. Aydin O,
    4. Yılmaz N
    (2014) Homocysteine, Paraoxonase-1 and Vascular Endothelial Dysfunction: Omnibus viis Romam Pervenitur. J Clin Diagn Res 8:1–4.
    OpenUrl
  12. 12.↵
    1. Pushpakumar S,
    2. Kundu S,
    3. Sen U
    (2014) Endothelial dysfunction: the link between homocysteine and hydrogen sulfide. Curr Med Chem 21:3662–3672.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Karbach S,
    2. Wenzel P,
    3. Waisman A,
    4. Munzel T,
    5. Daiber A
    (2014) eNOS uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation. Curr Pharm Des 20:3579–3594.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Emeksiz HC,
    2. Serdaroglu A,
    3. Biberoglu G,
    4. Gulbahar O,
    5. Arhan E,
    6. Cansu A,
    7. et al.
    (2013) Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. Seizure 22:124–127.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Esse R,
    2. Florindo C,
    3. Imbard A,
    4. Rocha MS,
    5. de Vriese AS,
    6. Smulders YM,
    7. et al.
    (2013) Global protein and histone arginine methylation are affected in a tissue-specific manner in a rat model of diet-induced hyperhomocysteinemia. Biochim Biophys Acta 1832:1708–1714.
    OpenUrlWeb of Science
  16. 16.↵
    1. Rocha MS,
    2. Teerlink T,
    3. Janssen MC,
    4. Kluijtmans LA,
    5. Smulders Y,
    6. Jakobs C,
    7. et al.
    (2012) Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency. Atherosclerosis 222:509–511.
    OpenUrl
  17. 17.↵
    1. Fabian E,
    2. Kickinger A,
    3. Wagner KH,
    4. Elmadfa I
    (2011) Homocysteine and asymmetric dimethylarginine in relation to B vitamins in elderly people. Wien Klin Wochenschr 123:496–501.
    OpenUrlPubMed
  18. 18.↵
    1. Akyürek Ö,
    2. Akbal E,
    3. Güneş F
    (2014) Increase in the risk of ST elevation myocardial infarction is associated with homocysteine level. Arch Med Res 45:501–506.
    OpenUrl
  19. 19.
    1. Wu Y,
    2. Huang Y,
    3. Hu Y,
    4. Zhong J,
    5. He Z,
    6. Li W,
    7. et al.
    (2013) Hyperhomocysteinemia is an independent risk factor in young patients with coronary artery disease in southern China. Herz 38:779–784.
    OpenUrl
  20. 20.
    1. Alam N,
    2. Khan HI,
    3. Chowdhury AW,
    4. Haque MS,
    5. Ali MS,
    6. Sabah KM,
    7. et al.
    (2012) Elevated serum homocysteine level has a positive correlation with serum cardiac troponin I in patients with acute myocardial infarction. Bangladesh Med Res Counc Bull 38:9–13.
    OpenUrlPubMed
  21. 21.↵
    1. Balogh E,
    2. Bereczky Z,
    3. Katona E,
    4. Koszegi Z,
    5. Edes I,
    6. Muszbek L,
    7. et al.
    (2012) Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: a case-control study. Thromb Res 129:133–138.
    OpenUrlPubMed
  22. 22.↵
    1. Esteghamati A,
    2. Hafezi-Nejad N,
    3. Zandieh A,
    4. Sheikhbahaei S,
    5. Ebadi M,
    6. Nakhjavani M
    (2014) Homocysteine and metabolic syndrome: From clustering to additional utility in prediction of coronary heart disease. J Cardiol 64:290–296.
    OpenUrl
  23. 23.↵
    1. Verdoia M,
    2. Schaffer A,
    3. Barbieri L,
    4. Cassetti E,
    5. Di Giovine G,
    6. Marino P,
    7. et al.
    (2015) Homocysteine and risk of periprocedural myocardial infarction in patients undergoing coronary stenting. J Cardiovasc Med (Hagerstown) 16:100–105.
    OpenUrl
  24. 24.↵
    1. Homocysteine Studies Collaboration
    (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288:2015–2022.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Humphrey LL,
    2. Fu R,
    3. Rogers K,
    4. Freeman M,
    5. Helfand M
    (2008) Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin Proc 83:1203–1212.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.↵
    1. Veeranna V,
    2. Zalawadiya SK,
    3. Niraj A,
    4. Pradhan J,
    5. Ference B,
    6. Burack RC,
    7. et al.
    (2011) Homocysteine and reclassification of cardiovascular disease risk. J Am Coll Cardiol 58:1025–1033.
    OpenUrlFREE Full Text
  27. 27.↵
    1. Drewes YM,
    2. Poortvliet RK,
    3. Blom JW,
    4. de Ruijter W,
    5. Westendorp RG,
    6. Stott DJ,
    7. et al.
    (2014) Homocysteine levels and treatment effect in the PROspective Study of Pravastatin in the Elderly at Risk. J Am Geriatr Soc 62:213–221.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Wu S,
    2. Gao X,
    3. Yang S,
    4. Meng M,
    5. Yang X,
    6. Ge B
    (2015) The role of endoplasmic reticulum stress in endothelial dysfunction induced by homocysteine thiolactone. Fundam Clin Pharmacol 29:252–259.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Lentz SR
    (2005) Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost 3:1646–1654.
    OpenUrlCrossRefPubMedWeb of Science
  30. 30.↵
    1. Laskowska M,
    2. Laskowska K,
    3. Terbosh M,
    4. Oleszczuk J
    (2013) A comparison of maternal serum levels of endothelial nitric oxide synthase, asymmetric dimethylarginine, and homocysteine in normal and preeclamptic pregnancies. Med Sci Monit 19:430–437.
    OpenUrl
  31. 32.↵
    1. Xiao Y,
    2. Huang W,
    3. Zhang J,
    4. Peng C,
    5. Xia M,
    6. Ling W
    (2015) Increased plasma S-adenosylhomocysteine-accelerated atherosclerosis is associated with epigenetic regulation of endoplasmic reticulum stress in apoE-/- mice. Arterioscler Thromb Vasc Biol 35:60–70.
    OpenUrlAbstract/FREE Full Text
  32. 32.↵
    1. Cao H,
    2. Hu X,
    3. Zhang Q,
    4. Li J,
    5. Liu B,
    6. Wang J,
    7. et al.
    (2014) Hyperhomocysteinaemia, low folate concentrations and MTHFR C677T mutation in abdominal aortic aneurysm. Vasa 43:181–188.
    OpenUrl
  33. 33.↵
    1. Shamkani WA,
    2. Jafar NS,
    3. Narayanan SR,
    4. Rajappan AK
    (2015) Acute Myocardial Infarction in a Young Lady due to Vitamin B12 Deficiency Induced Hyperhomocysteinemia. Heart Views 16:25–29.
    OpenUrl
  34. 34.↵
    1. Ji Y,
    2. Tan S,
    3. Xu Y,
    4. Chandra A,
    5. Shi C,
    6. Song B,
    7. et al.
    (2013) Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: a meta-analysis. Neurology 81:1298–1307.
    OpenUrlCrossRefPubMed
  35. 35.↵
    1. Cheng D,
    2. Kong H,
    3. Pang W,
    4. Yang H,
    5. Lu H,
    6. Huang C,
    7. et al.
    (Jun 18, 2014) B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutr Neurosci, [Epub ahead of print].
  36. 36.↵
    1. Obersby D,
    2. Chappell DC,
    3. Dunnett A,
    4. Tsiami AA
    (2013) Plasma total homocysteine status of vegetarians compared with omnivores: a systematic review and meta-analysis. Br J Nutr 109:785–794.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. Liu XD,
    2. Gao B,
    3. Sun D,
    4. Shi M,
    5. Ma YY,
    6. Liu ZR,
    7. et al.
    (2015) Prevalence of hyperhomocysteinaemia and some of its major determinants in Shaanxi Province, China: a cross-sectional study. Br J Nutr 113:691–698.
    OpenUrl
  38. 38.↵
    1. Katko M,
    2. Zavaczki E,
    3. Jeney V,
    4. Paragh G,
    5. Balla J,
    6. Varga Z
    (2012) Homocysteine metabolism in peripheral blood mononuclear cells: evidence for cystathionine beta-synthase activity in resting state. Amino Acids 43:317–326.
    OpenUrlPubMed
  39. 39.↵
    1. Taguchi T,
    2. Mori H,
    3. Hamada A,
    4. Yamori Y,
    5. Mori M
    (2012) Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese. Asia Pac J Clin Nutr 21:291–295.
    OpenUrlPubMed
  40. 40.↵
    1. Ward M,
    2. Wilson CP,
    3. Strain JJ,
    4. Horigan G,
    5. Scott JM,
    6. McNulty H
    (2011) B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertension. Int J Vitam Nutr Res 81:240–244.
    OpenUrlCrossRefPubMed
  41. 41.↵
    1. Bozok Çetintaş V,
    2. Gündüz C
    (2014) Association between polymorphism of MTHFR c.677C>T and risk of cardiovascular disease in Turkish population: a meta-analysis for 2.780 cases and 3.022 controls. Mol Biol Rep 41:397–409.
    OpenUrlCrossRefPubMed
  42. 42.↵
    1. Taban-Shomal O,
    2. Kilter H,
    3. Wagner A,
    4. Schorr H,
    5. Umanskaya N,
    6. Hübner U,
    7. et al.
    (2009) The cardiac effects of prolonged vitamin B12 and folate deficiency in rats. Cardiovasc Toxicol 9:95–102.
    OpenUrlPubMed
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