Review ArticleReview Article
Open Access

Nigella sativa and its active constituent thymoquinone in oral health

Safia A. AlAttas, Fat’heya M. Zahran and Shereen A. Turkistany
Saudi Medical Journal March 2016, 37 (3) 235-244; DOI: https://doi.org/10.15537/smj.2016.3.13006

References

  1. ↵
    1. Abd-Awn B,
    2. Al-Dhaher Z,
    3. Al-Dafaai R
    (2012) The effect of black seed oil extracts on mutans streptococci in comparison to chlorhexidine gluconate (in vitro). Journal of Baghdad College of Dentistry 24:126–131.
    OpenUrl
  2. ↵
    1. World Health Organization
    (2002) Traditional medicine strategy 2002-2005 (WHO Publications, Geneva (CH)), pp 1–6.
  3. ↵
    1. Ahmad I,
    2. Tripathi J,
    3. Sharma M,
    4. Karchulli MS,
    5. Umer L
    (2014) Nigella sativa - a medicinal herb with immense therapeutic potential (a systematic review). International Journal of Biological & Pharmaceutical Research 5:755–762.
    OpenUrl
  4. ↵
    1. Ahmad A,
    2. Husain A,
    3. Mujeeb M,
    4. Khan S,
    5. Najmi A,
    6. Siddique N,
    7. et al.
    (2013) A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed 3:337–352.
    OpenUrlCrossRefPubMed
  5. ↵
    1. Tariq M
    (2008) Nigella sativa feeds: folklore treatment in modern day medicine. Saudi J Gastroenterol 14:105–106.
    OpenUrl
  6. ↵
    1. Shrivastava R,
    2. Agrawal R,
    3. Parveen Z
    (2011) A review on therapeutic applications of Nigella Sativa. Journal of Chemistry and Chemical Sciences 1:241–248.
    OpenUrl
  7. ↵
    1. Gaur S,
    2. Shrivastava B,
    3. Gaur S,
    4. Bhardwaj R,
    5. Khanchandani R
    (2014) Medicinal and therapeutical potential of Nigella sativa. International Journal of Medical and Applied Sciences Research 1:32–39.
    OpenUrl
  8. ↵
    1. Tembhurne S,
    2. Feroz S,
    3. More B,
    4. Sakarkar D
    (2014) A review on therapeutic potential of Nigella sativa (kalonji) seeds. Journal of Medicinal Plants Research 8:167–177.
    OpenUrl
  9. ↵
    1. Rahmani AH,
    2. Alzohairy MA,
    3. Khan MA,
    4. Aly SM
    (2015) Nigella Sativa and its active constituents thymoquinone shows pivotal role in the diseases prevention and treatment. Asian Journal of Pharmaceutical and Clinical Research 8:48–53.
    OpenUrl
  10. ↵
    1. de Oliveira JR1,
    2. de Castro VC,
    3. das Graças Figueiredo Vilela P,
    4. Camargo SE,
    5. Carvalho CA,
    6. Jorge AO,
    7. et al.
    (2013) Cytotoxicity of Brazilian plant extracts against oral microorganisms of interest to dentistry. BMC Complement Altern Med 13:208.
    OpenUrlCrossRef
    1. Ocheng F,
    2. Bwanga F,
    3. Joloba M,
    4. Borg-Karlson AK,
    5. Gustafsson A,
    6. Obua C
    (2014) Antibacterial activities of extracts from Ugandan medicinal plants used for oral care. J Ethnopharmacol 155:852–855.
    OpenUrl
  12. ↵
    1. Haque M,
    2. Alsareii S
    (2015) A review of the therapeutic effects of using miswak (Salvadora Persica) on oral health. Saudi Med J 36:530–543.
    OpenUrlAbstract/FREE Full Text
  13. ↵
    1. Shaker A,
    2. Al-Wafi H
    (2014) Benefits of thymoquinone, a Nigella Sativa extract in preventing dental caries initiation and improving gingival health. ProQuest LLC, 72.
    1. Gómez SI,
    2. Jaramillo LM,
    3. Moreno GC,
    4. Roa NS,
    5. Rodríguez A
    (2015) Differential reactivity of salivary IgA and IgG against Streptococcus mutans proteins in humans with different caries experience. Acta Odontol Latinoam 28:3–12.
    OpenUrl
  15. ↵
    1. Angius F,
    2. Madeddu MA,
    3. Pompei R
    (2015) Nutritionally variant streptococci interfere with streptococcus mutans adhesion properties and biofilm formation. New Microbiol 38:259–266.
    OpenUrl
  16. ↵
    1. World Health Organization
    (2012) Oral Health Fact Sheet N°318 (World Health Organization, Geneva (CH)).
  17. ↵
    1. Pai MR,
    2. Acharya LD,
    3. Udupa N
    (2004) Evaluation of antiplaque activity of Azadirachta indica leaf extract gel a 6-week clinical study. J Ethnopharmacol 90:99–103.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Harzallah H,
    2. Kouidhi B,
    3. Flamini G,
    4. Bakhrouf A,
    5. Mahjoub T
    (2011) Chemical composition, antimicrobial potential against cariogenic bacteria and cytotoxic activity of Tunisian Nigella sativa essential oil and thymoquinone. Food Chemistry 129:1469–1474.
    OpenUrl
  19. ↵
    1. Gupta P,
    2. Gupta N,
    3. Pawar AP,
    4. Birajdar SS,
    5. Natt AS,
    6. Singh HP
    (2013) Role of sugar and sugar substitutes in dental caries: a review. ISRN Dent 2013, 519421.
  20. ↵
    1. Mazumdar M,
    2. Chatterjee A,
    3. Majumdar S,
    4. Chandrika M,
    5. Patki PS
    (2013) Evaluation of the Safety and Efficacy of Complete Care Herbal Toothpaste in Controlling Dental Plaque, Gingival Bleeding and Periodontal Diseases. J Homeop Ayurv Med 2:124.
    OpenUrl
  21. ↵
    1. Khalid A,
    2. Rehman U,
    3. Sethi A,
    4. Khilji S,
    5. Urooj F,
    6. Khan M,
    7. et al.
    (2011) Antimicrobial activity analysis of extracts of Acacia modesta, Artimisia absinthium, Nigella sativa and Saussurea lappa against Gram positive and Gram negative microorganisms. African Journal of Biotechnology 10:4574–4580.
    OpenUrl
  22. ↵
    1. Kouidhi B,
    2. Zmantar T,
    3. Jrah H,
    4. Souiden Y,
    5. Chaieb K,
    6. Mahdouani K,
    7. et al.
    (2011) Antibacterial and resistance-modifying activities of thymoquinone against oral pathogens. Ann Clin Microbiol Antimicrob 10:29.
    OpenUrlPubMed
  23. ↵
    1. Bakathir HA,
    2. Abbas NA
    (2011) Detection of the antibacterial effect of Nigella sativa ground seeds with water. Afr J Tradit Complement Altern Med 8:159–164.
    OpenUrlCrossRefPubMed
  24. ↵
    1. Mohammed NA
    (2012) Effect of Nigella Sativa L extracts against streptococcus mutans and streptococcus mitis in vitro. Journal of Baghdad College of Dentistry 24:154–157.
    OpenUrl
  25. ↵
    1. Lucas VS,
    2. Roberts GJ
    (2005) Oro-dental health in children with chronic renal failure and after renal transplantation: a clinical review. Pediatr Nephrol 20:1388–1394.
    OpenUrlCrossRefPubMedWeb of Science
  26. ↵
    1. Al-Bayaty F,
    2. Kamaruddin A,
    3. Ismail M,
    4. Abdulla M
    (2013) Formulation and Evaluation of a New Biodegradable Periodontal Chip Containing Thymoquinone in a Chitosan Base for the Management of Chronic Periodontitis. Journal of Nanomaterials 2013, 397308.
  27. ↵
    1. Loos BG
    (2006) Systemic effects of periodontitis. Int J Dent Hyg 4:34–38.
    OpenUrlCrossRef
  28. ↵
    1. Bokhari SA,
    2. Khan AA
    (2009) Growing burden of noncommunicable diseases: the contributory role of oral diseases, Eastern Mediterranean Region perspective. East Mediterr Health J 15:1011–1020.
    OpenUrlPubMed
  29. ↵
    1. Wahid A,
    2. Chaudhry S,
    3. Ehsan A,
    4. Butt S,
    5. Khan AA
    (2013) Bidirectional relationship between chronic kidney disease and periodontal disease. Pak J Med Sci 29:211–215.
    OpenUrl
  30. ↵
    1. Haas AN,
    2. Pannuti CM,
    3. Andrade AKP,
    4. Escobar EC,
    5. Almeida ER,
    6. Costa FO,
    7. et al.
    (2014) Mouthwashes for the control of supragingival biofilm and gingivitis in orthodontic patients: evidence-based recommendations for clinicians. Braz Oral Res 28:1–8.
    OpenUrl
  31. ↵
    1. Van Leeuwen MP,
    2. Slot DE,
    3. Van der Weijden GA
    (2011) Essential oils compared to chlorhexidine with respect to plaque and parameters of gingival inflammation: a systematic review. J Periodontol 82:174–194.
    OpenUrlCrossRefPubMed
  32. ↵
    1. Ozdemir H,
    2. Kara MI,
    3. Erciyas K,
    4. Ozer H,
    5. Ay S
    (2012) Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study. J Periodontal Res 47:74–80.
    OpenUrlPubMed
  33. ↵
    1. Nader MI,
    2. Al-Thwaini AN,
    3. Abdul-Hassan IA,
    4. Ali AW
    (2010) Effect of Nigella Sativa (black seed) Salvadora Persica (Siwak) and aluminum potassium sulphate (ALUM) aqueous extracts on isolated bacteria from teeth root canal. Iraqi J Biotech 9:99–104.
    OpenUrl
  34. ↵
    1. Senia ES,
    2. Marshall FJ,
    3. Rosen S
    (1971) The solvent action of sodium hypochlorite on pulp tissue of extracted teeth. Oral Surg Oral Med Oral Pathol 31:96–103.
    OpenUrlPubMed
  35. ↵
    1. Jhajharia K,
    2. Parolia A,
    3. Shetty KV,
    4. Mehta LK
    (2015) Biofilm in endodontics: A review. J Int Soc Prev Community Dent 5:1–12.
    OpenUrl
  36. ↵
    1. Omar OM,
    2. Khattab NM,
    3. Khater DS
    (2012) Nigella Sativa oil as a pulp medicament for pulpotomized teeth: a histopathological evaluation. J Clin Pediatr Dent 36:335–342.
    OpenUrlPubMed
  37. ↵
    1. Porter SR,
    2. Leao JC
    (2005) Review article: oral ulcers and its relevance to systemic disorders. Aliment Pharmacol Ther 21:295–306.
    OpenUrlCrossRefPubMedWeb of Science
  38. ↵
    1. Muñoz-Corcuera M,
    2. Esparza-Gómez G,
    3. González-Moles MA,
    4. Bascones-Martínez A
    (2009) Oral ulcers: clinical aspects. A tool for dermatologists. Part I. Acute ulcers. Clin Exp Dermatol 34:289–294.
    OpenUrlPubMed
  39. ↵
    1. Al-Douri A,
    2. Al-Kazaz S
    (2010) The effect of Nigella Sativa oil (black seed) on the healing of chemically induced oral ulcer in rabbit (experimental study). Al-Rafidain Dent J 10:151–157.
    OpenUrl
  40. ↵
    1. Lotfy AO,
    2. Zayed M
    (2009) Immunohistochemical study of the effect of Nigella Sativa L extract on chemotherapy induced oral mucositis in Albino rats. Cairo Dental Journal 25:159–166.
    OpenUrl
  41. ↵
    1. Ab Rahman MR,
    2. Abdul Razak F,
    3. Mohd Bakri M
    (2014) Evaluation of wound closure activity of Nigella sativa, Melastoma malabathricum, Pluchea indica, and Piper sarmentosum extracts on scratched monolayer of human gingival fibroblasts. Evid Based Complement Alternat Med 2014, 190342.
  42. ↵
    1. Al-Hijazi AY,
    2. Mohammed HS
    (2013) Evaluation of the effect of Nigella Sativa oil and powder on socket healing process. Journal of Natural Sciences Research 13:135–141.
    OpenUrl
  43. ↵
    1. Alnajar SSA,
    2. Mohammed SA
    (2009) Mechanical and histological significance of Nigella Sativa oil extract on bone-implant interface. Journal of Baghdad College of Dentistry 21:39–43.
    OpenUrl
  44. ↵
    1. El-Sweify AA,
    2. Hassan MM,
    3. Ahmed IH,
    4. Basha AA
    (2008) Comparative study between the effect of calcium hydroxide mixed with Nigella Sativa oil versus bioglass on healing of induced mandibular bone defects in rats. SCVMJ 13:449–459.
    OpenUrl
  45. ↵
    1. Laysar HA,
    2. Niakan M,
    3. Taghi GM,
    4. Jafarian Z,
    5. Mostafavizade M,
    6. Niakan S
    (2013) Comparison of the antibacterial activity of various concentrations of Nigella Sativa and Nanosilver on the growth of S. sanguis and S. mutans. J Res Dent Sci 9:179–186.
    OpenUrl
  46. ↵
    1. Farah CS,
    2. Lynch N,
    3. McCullough MJ
    (2010) Oral fungal infections: an update for the general practitioner. Aust Dent J 55(Suppl 1):48–54.
    OpenUrlCrossRefPubMed
  47. ↵
    1. Fani MM,
    2. Kohanteb J,
    3. Dayaghi M
    (2007) Inhibitory activity of garlic (Allium sativum) extract on multidrug-resistant Streptococcus mutans. J Indian Soc Pedod Prev Dent 25:164–168.
    OpenUrlCrossRefPubMed
    1. Alsaidy D
    (2014) Isolate, Diagnosis and Treatment of Yeast Candida albicans accompanying the human body. International Journal of Advanced Research 2:1081–1086.
    OpenUrl
    1. Doudi M,
    2. Setorki M,
    3. Hoveyda L
    (2014) Comparing the antifungal effects of five essential oils plants eucalyptus, cinnamon, wormwood, sagebrush and iranian rose damascena on three standard strains of candida albicans in vitro. International Journal of Biology, Pharmacy and Allied Sciences 3:490–500.
    OpenUrl
  50. ↵
    1. Fareid MA
    (2014) In vitro: evaluation of inhibitory activity of some plant extracts against oral candidiasis. New York Science Journal 7:66–76.
    OpenUrl
  51. ↵
    1. Randhawa MA,
    2. Gondal M,
    3. Al-Zahrani A,
    4. Rashid SG,
    5. Ali A
    (2015) Synthesis, morphology and antifungal activity of nano-particulated amphotericin-B, ketoconazole and thymoquinone against Candida albicans yeasts and Candida biofilm. J Environ Sci Health A Tox Hazard Subst Environ Eng 50:119–124.
    OpenUrl
  52. ↵
    1. Califano J,
    2. van der Riet P,
    3. Westra W,
    4. Nawroz H,
    5. Clayman G,
    6. Piantadosi S,
    7. et al.
    (1996) Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 56:2488–2492.
    OpenUrlAbstract/FREE Full Text
  53. ↵
    1. Jaiswal G,
    2. Jaiswal S,
    3. Kumar R,
    4. Sharma A
    (2013) Field cancerization: concept and clinical implications in head and neck squamous cell carcinoma. J Exp Ther Oncol 10:209–214.
    OpenUrlPubMed
  54. ↵
    1. Arnaoutakis D,
    2. Bishop J,
    3. Westra W,
    4. Califano JA
    (2013) Recurrence patterns and management of oral cavity premalignant lesions. Oral Oncol 49:814–817.
    OpenUrlCrossRefPubMed
  55. ↵
    1. Kuriakose MA,
    2. Sharan R
    (2006) Oral cancer prevention. Oral Maxillofac Surg Clin North Am 18:493–511.
    OpenUrl
  56. ↵
    1. Khan Z,
    2. Bisen PS
    (2013) Oncoapoptotic signaling and deregulated target genes in cancers: special reference to oral cancer. Biochim Biophys Acta 1836:123–145.
    OpenUrlPubMed
    1. Saba NF,
    2. Haigentz M Jr.,
    3. Vermorken JB,
    4. Strojan P,
    5. Bossi P,
    6. Rinaldo A,
    7. et al.
    (2015) Prevention of head and neck squamous cell carcinoma: removing the “chemo” from “chemoprevention” Oral Oncol 51:112–118.
    OpenUrl
  58. ↵
    1. Thompson L
    (2006) World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J 85:74.
    OpenUrlPubMed
  59. ↵
    1. Brown RK,
    2. Wilson G,
    3. Tucci MA,
    4. Benghuzzi HA
    (2014) The effects of thymoquinone and Doxorubicin on leukemia and cardiomyocyte cell lines. Biomed Sci Instrum 50:391–396.
    OpenUrl
  60. ↵
    1. Chu SC,
    2. Hsieh YS,
    3. Yu CC,
    4. Lai YY,
    5. Chen PN
    (2014) Thymoquinone induces cell death in human squamous carcinoma cells via caspase activation-dependent apoptosis and LC3-II activation-dependent autophagy. PloS One 9:e101579.
    OpenUrl
  61. ↵
    1. Sutton KM,
    2. Greenshields AL,
    3. Hoskin DW
    (2014) Thymoquinone a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53. Nutr Cancer 66:408–418.
    OpenUrl
  62. ↵
    1. Jafri SH,
    2. Glass J,
    3. Shi R,
    4. Zhang S,
    5. Prince M,
    6. Kleiner-Hancock H
    (2010) Thymoquinone and cisplatin as a therapeutic combination in lung cancer: in vitro and in vivo. J Exp Clin Cancer Res 29:87.
    OpenUrlPubMed
  63. ↵
    1. Rajkamal G,
    2. Suresh K,
    3. Sugunadevi G,
    4. Vijayaanand MA,
    5. Rajalingam K
    (2010) Evaluation of chemopreventive effects of Thymoquinone on cell surface glycoconjugates and cytokeratin expression during DMBA induced hamster buccal pouch carcinogenesis. BMB Rep 43:664–669.
    OpenUrlPubMed
  64. ↵
    1. Abdelfadil E,
    2. Cheng YH,
    3. Bau DT,
    4. Ting WJ,
    5. Chen LM,
    6. Hsu HH,
    7. et al.
    (2013) Thymoquinone induces apoptosis in oral cancer cells through p38beta inhibition. Am J Chin Med 41:683–696.
    OpenUrl
  65. ↵
    1. Speirs CK,
    2. Hwang M,
    3. Kim S,
    4. Li W,
    5. Chang S,
    6. Varki V,
    7. et al.
    (2011) Harnessing the cell death pathway for targeted cancer treatment. Am J Cancer Res 1:43–61.
    OpenUrlPubMed
  66. ↵
    1. Gewirtz DA
    (2013) Cytoprotective and nonprotective autophagy in cancer therapy. Autophagy 9:1263–1265.
    OpenUrl
  67. ↵
    1. Gali-Muhtasib HU,
    2. Abou Kheir WG,
    3. Kheir LA,
    4. Darwiche N,
    5. Crooks PA
    (2004) Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs 15:389–399.
    OpenUrlCrossRefPubMed
  68. ↵
    1. ElKhoely A,
    2. Hafez HF,
    3. Ashmawy AM,
    4. Badary O,
    5. Abdelaziz A,
    6. Mostafa A,
    7. et al.
    (2015) Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives. J Nat Med 69:313–323.
    OpenUrl
  69. ↵
    1. Al-Attas SA,
    2. Munshi A,
    3. Noorwali A,
    4. Algrigri MA,
    5. Abohager EA,
    6. Zahran FM
    (2015) Nigella sativa extract chemoprevention in oral cancer: in vivo study. Advances in Environmental Biology 9:75–90.
    OpenUrl
  70. ↵
    1. Al-Quorain AA
    (2015) Nigella Sativa. Saudi J Med Med Sci 3:1.
    OpenUrl
  71. ↵
    1. Bashir MU,
    2. Qureshi HJ
    (2010) Analgesic effect of Nigella sativa seeds extract on experimentally induced pain in albino mice. J Coll Physicians Surg Pak 20:464–467.
    OpenUrlPubMed
  72. ↵
    1. Osman MT,
    2. Hamza AJ,
    3. Omar E,
    4. Adnan A
    (2014) The new miracle of Habbatus Sauda: its major component thymoquinone can be used in the management of autoimmune diseases. Procedia -Social and Behavioral Sciences 121:304–314.
    OpenUrl
  73. ↵
    1. Salem ML
    (2005) Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 5:1749–1770.
    OpenUrlCrossRefPubMedWeb of Science
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