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Review ArticleSystematic Review
Open Access

Influence of the CYP4F2 polymorphism on the risk of hemorrhagic complications in coumarin-treated patients

Peng Chen, Ye-Qi Sun, Guo-Ping Yang, Rong Li, Jie Pan and Yu-Sheng Zhou
Saudi Medical Journal April 2016, 37 (4) 361-368; DOI: https://doi.org/10.15537/smj.2016.4.14036
Peng Chen
From the Institute of Pharmacy & Pharmacology (Chen), University of South China, the Department of Pathology (Sun), First Affiliated Hospital of University of South China, the Department of Pharmacy (Li, Pan, Zhou), Second Affiliated Hospital of University of South China, Hengyang, the Center of Clinical Pharmacology (Yang), Third Xiangya Hospital, Central South University, Changsha, China
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Ye-Qi Sun
From the Institute of Pharmacy & Pharmacology (Chen), University of South China, the Department of Pathology (Sun), First Affiliated Hospital of University of South China, the Department of Pharmacy (Li, Pan, Zhou), Second Affiliated Hospital of University of South China, Hengyang, the Center of Clinical Pharmacology (Yang), Third Xiangya Hospital, Central South University, Changsha, China
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Guo-Ping Yang
From the Institute of Pharmacy & Pharmacology (Chen), University of South China, the Department of Pathology (Sun), First Affiliated Hospital of University of South China, the Department of Pharmacy (Li, Pan, Zhou), Second Affiliated Hospital of University of South China, Hengyang, the Center of Clinical Pharmacology (Yang), Third Xiangya Hospital, Central South University, Changsha, China
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Rong Li
From the Institute of Pharmacy & Pharmacology (Chen), University of South China, the Department of Pathology (Sun), First Affiliated Hospital of University of South China, the Department of Pharmacy (Li, Pan, Zhou), Second Affiliated Hospital of University of South China, Hengyang, the Center of Clinical Pharmacology (Yang), Third Xiangya Hospital, Central South University, Changsha, China
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Jie Pan
From the Institute of Pharmacy & Pharmacology (Chen), University of South China, the Department of Pathology (Sun), First Affiliated Hospital of University of South China, the Department of Pharmacy (Li, Pan, Zhou), Second Affiliated Hospital of University of South China, Hengyang, the Center of Clinical Pharmacology (Yang), Third Xiangya Hospital, Central South University, Changsha, China
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Yu-Sheng Zhou
From the Institute of Pharmacy & Pharmacology (Chen), University of South China, the Department of Pathology (Sun), First Affiliated Hospital of University of South China, the Department of Pharmacy (Li, Pan, Zhou), Second Affiliated Hospital of University of South China, Hengyang, the Center of Clinical Pharmacology (Yang), Third Xiangya Hospital, Central South University, Changsha, China
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    Figure 1

    Flow diagram showing the number of citations identified, retrieved, extracted, and included in the final analysis.

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    Figure 2

    Forest plots of bleeding in carriers of CYP4F2*3 compared with CYP4F2*1*1 in: A) showing the association between CYP4F2*3 and total hemorrhages; and B) showed the association between CYP4F2*3 and major hemorrhage. Events/total - the numbers of patients with events/the numbers of total patients.

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    Figure 3

    Forest plots of over-anticoagulation in the CYP4F2*3 variant as compared with CYP4F2*1*1 in: A) showed the relative over-anticoagulation of carriers of CYP4F2*3 compared with CYP4F2*1*1, and subgroup analysis according to coumarin drugs, and B) showed the relative over-anticoagulation of homozygotes for CYP4F2*3 compared with CYP4F2*1*1. Events/total - the numbers of patients with events/the numbers of total patients.

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Saudi Medical Journal: 37 (4)
Saudi Medical Journal
Vol. 37, Issue 4
1 Apr 2016
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Influence of the CYP4F2 polymorphism on the risk of hemorrhagic complications in coumarin-treated patients
Peng Chen, Ye-Qi Sun, Guo-Ping Yang, Rong Li, Jie Pan, Yu-Sheng Zhou
Saudi Medical Journal Apr 2016, 37 (4) 361-368; DOI: 10.15537/smj.2016.4.14036

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Influence of the CYP4F2 polymorphism on the risk of hemorrhagic complications in coumarin-treated patients
Peng Chen, Ye-Qi Sun, Guo-Ping Yang, Rong Li, Jie Pan, Yu-Sheng Zhou
Saudi Medical Journal Apr 2016, 37 (4) 361-368; DOI: 10.15537/smj.2016.4.14036
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