Research ArticleOriginal Article
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Differential diagnosis between pancreatic neuroendocrine and solid pseudopapillary neoplasms on endoscopic ultrasound-guided fine-needle aspiration

An immunohistochemical study

Emad M. Raddaoui, Majid A. Almadi, Abdulrahman M. Aljebreen, Faisal A. Alsaif, Ahlam A. AlShedoukhy, Abed H. Al-Lehibi, Khalid A. Almohameed, Apostolos V. Tsolakis, Mousa A. AlAbbadi and Amna R. Almutrafi
Saudi Medical Journal July 2016, 37 (7) 744-749; DOI: https://doi.org/10.15537/smj.2016.7.14212

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    Pancreatic endocrine neoplasm, highly cellular aspirate composed of uniform, discohesive cells and A) revealing the typical finely distributed “salt-and-pepper” chromatin, Pap Stain (50x), B) Immunohistochemistry stains performed on cellblock showed that tumor cells are positive for synaptophysin, IHC stain (40x), C) with membranous positivity for E-cadherin, IHC stain (40x), D) IHC staining for B-catenin revealed membranous/cytoplasmic distribution with clear absence of nuclear staining, IHC stain (40x). IHC - immunohistochemical

  • Figure 2
    Figure 2

    Solid pseudopapillary neoplasm, cellular smear with loose clusters as well as scattered well-formed papillary structures. A) The cells have delicate to clear cytoplasm and bland nuclei with fine chromatin, Pap stain (40x), B) Immunohistochemistry stains obtained on cellblock preparation showed that tumor cells are positive for B-catenin, nuclear pattern, IHC stain (40x), and C) Same cells are negative for E-cadherin, IHC stain (40x). IHC - immunohistochemical

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