Differential diagnosis between pancreatic neuroendocrine and solid pseudopapillary neoplasms on endoscopic ultrasound-guided fine-needle aspiration: An immunohistochemical study

Emad M. Raddaoui; Majid A. Almadi; Abdulrahman M. Aljebreen; Faisal A. Alsaif; Ahlam A. AlShedoukhy; Abed H. Al-Lehibi; Khalid A. Almohameed; Apostolos V. Tsolakis; Mousa A. AlAbbadi; Amna R. Almutrafi

doi:10.15537/smj.2016.7.14212

References

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1. Wilson JL,
2. Kalade A,
3. Prasad S,
4. Cade R,
5. Thomson B,
6. Banting S,
7. et al.
(2009) Diagnosis of solid pancreatic masses by endoscopic ultrasound-guided fine-needle aspiration. Intern Med J 39:32–37.
OpenUrl CrossRef PubMed
↵
1. Frankel WL
(2006) Update on pancreatic endocrine tumors. Arch Pathol Lab Med 130:963–966.
OpenUrl PubMed
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1. Geers C,
2. Moulin P,
3. Gigot JF,
4. Weynand B,
5. Deprez P,
6. Rahier J,
7. et al.
(2006) Solid and pseudopapillary tumor of the pancreas--review and new insights into pathogenesis. Am J Surg Pathol 30:1243–1249.
OpenUrl CrossRef PubMed Web of Science
↵
1. Chen G,
2. Liu S,
3. Zhao Y,
4. Dai M,
5. Zhang T
(2013) Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration for pancreatic cancer: a meta-analysis. Pancreatology 13:298–304.
OpenUrl
↵
1. Abdelgawwad MS,
2. Alston E,
3. Eltoum IA
(2013) The frequency and cancer risk associated with the atypical cytologic diagnostic category in endoscopic ultrasound-guided fine-needle aspiration specimens of solid pancreatic lesions: a meta-analysis and argument for a Bethesda System for Reporting Cytopathology of the Pancreas. Cancer Cytopathol 121:620–628.
OpenUrl CrossRef PubMed
↵
1. Ehehalt F,
2. Saeger HD,
3. Schmidt CM,
4. Grützmann R
(2009) Neuroendocrine tumors of the pancreas. Oncologist 14:456–467.
OpenUrl Abstract/FREE Full Text
↵
1. Lepage C,
2. Bouvier AM,
3. Phelip JM,
4. Hatem C,
5. Vernet C,
6. Faivre J
(2004) Incidence and management of malignant digestive endocrine tumours in a well defined French population. Gut 53:549–553.
OpenUrl Abstract/FREE Full Text
↵
1. Puli SR,
2. Kalva N,
3. Bechtold ML,
4. Pamulaparthy SR,
5. Cashman MD,
6. Estes NC,
7. et al.
(2013) Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: a systematic review and meta analysis. World J Gastroenterol 19:3678–3684.
OpenUrl
↵
1. Law JK,
2. Ahmed A,
3. Singh VK,
4. Akshintala VS,
5. Olson MT,
6. Raman SP,
7. et al.
(2014) A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas 43:331–337.
OpenUrl CrossRef PubMed
↵
1. Li L,
2. Othman M,
3. Rashid A,
4. Wang H,
5. Li Z,
6. Katz MH,
7. et al.
(2013) Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells. Histopathology 62:465–471.
OpenUrl
↵
1. Jung WS,
2. Kim JK,
3. Yu JS,
4. Kim JH,
5. Cho ES,
6. Chung JJ
(2014) Comparison of abdominal ultrasonographic findings with endoscopic ultrasonographic findings of solid pseudopapillary neoplasms of the pancreas. Ultrasound Q 30:173–178.
OpenUrl
↵
1. Law JK,
2. Stoita A,
3. Wever W,
4. Gleeson FC,
5. Dries AM,
6. Blackford A,
7. et al.
(2014) Endoscopic ultrasound-guided fine needle aspiration improves the pre-operative diagnostic yield of solid-pseudopapillary neoplasm of the pancreas: an international multicenter case series (with video). Surg Endosc 28:2592–2598.
OpenUrl
↵
1. Terris B,
2. Cavard C
(2014) Diagnosis and molecular aspects of solid-pseudopapillary neoplasms of the pancreas. Semin Diagn Pathol 31:484–490.
OpenUrl
↵
1. Jhala N,
2. Siegal GP,
3. Jhala D
(2008) Large, clear cytoplasmic vacuolation: an under-recognized cytologic clue to distinguish solid pseudopapillary neoplasms of the pancreas from pancreatic endocrine neoplasms on fine-needle aspiration. Cancer 114:249–254.
OpenUrl CrossRef PubMed
↵
1. Samad A,
2. Shah AA,
3. Stelow EB,
4. Alsharif M,
5. Cameron SE,
6. Pambuccian SE
(2013) Cercariform cells: another cytologic feature distinguishing solid pseudopapillary neoplasms from pancreatic endocrine neoplasms and acinar cell carcinomas in endoscopic ultrasound-guided fine-needle aspirates. Cancer Cytopathol 121:298–310.
OpenUrl
↵
1. Layfield LJ,
2. Ehya H,
3. Filie AC,
4. Hruban RH,
5. Jhala N,
6. Joseph L,
7. et al.
(2014) Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: the Papanicolaou Society of Cytopathology guidelines for pancreatobiliary cytology. Diagn Cytopathol 42:351–362.
OpenUrl CrossRef PubMed
↵
1. Notohara K,
2. Hamazaki S,
3. Tsukayama C,
4. Nakamoto S,
5. Kawabata K,
6. Mizobuchi K,
7. et al.
(2000) Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and CD10. Am J Surg Pathol 24:1361–1371.
OpenUrl CrossRef PubMed Web of Science
↵
1. Burford H,
2. Baloch Z,
3. Liu X,
4. Jhala D,
5. Siegal GP,
6. Jhala N
(2009) E-cadherin/beta-catenin and CD10: a limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreas. Am J Clin Pathol 132:831–839.
OpenUrl CrossRef PubMed
↵
1. Adams AL,
2. Siegal GP,
3. Jhala NC
(2008) Solid pseudopapillary tumor of the pancreas: a review of salient clinical and pathologic features. Adv Anat Pathol 15:39–45.
OpenUrl CrossRef PubMed Web of Science
↵
1. El-Bahrawy MA,
2. Rowan A,
3. Horncastle D,
4. Tomlinson I,
5. Theis BA,
6. Russell RC,
7. et al.
(2008) E-cadherin/catenin complex status in solid pseudopapillary tumor of the pancreas. Am J Surg Pathol 32:1–7.
OpenUrl CrossRef PubMed Web of Science
↵
1. Scarpa A,
2. Mantovani W,
3. Capelli P,
4. Beghelli S,
5. Boninsegna L,
6. Bettini R,
7. et al.
(2010) Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients. Mod Pathol 23:824–833.
OpenUrl CrossRef PubMed Web of Science
↵
1. Franchi G,
2. Manzoni MF
(2014) Cytological Ki-67 in pancreatic endocrine tumors: a new “must”? Gland Surg 3:219–221.
OpenUrl PubMed
↵
1. Hasegawa T,
2. Yamao K,
3. Hijioka S,
4. Bhatia V,
5. Mizuno N,
6. Hara K,
7. et al.
(2014) Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors. Endoscopy 46:32–38.
OpenUrl CrossRef PubMed
↵
1. Vinayek R,
2. Capurso G,
3. Larghi A
(2014) Grading of EUS-FNA cytologic specimens from patients with pancreatic neuroendocrine neoplasms: it is time move to tissue core biopsy? Gland Surg 3:222–225.
OpenUrl
↵
1. Hooper K,
2. Mukhtar F,
3. Li S,
4. Eltoum IA
(2013) Diagnostic error assessment and associated harm of endoscopic ultrasound-guided fine-needle aspiration of neuroendocrine neoplasms of the pancreas. Cancer Cytopathol 121:653–660.
OpenUrl

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[1] ↵
Wilson JL,
Kalade A,
Prasad S,
Cade R,
Thomson B,
Banting S,
et al.
(2009) Diagnosis of solid pancreatic masses by endoscopic ultrasound-guided fine-needle aspiration. Intern Med J 39:32–37.
OpenUrl CrossRef PubMed

[2] Wilson JL,

[3] Kalade A,

[4] Prasad S,

[5] Cade R,

[6] Thomson B,

[7] Banting S,

[8] et al.

[9] ↵
Frankel WL
(2006) Update on pancreatic endocrine tumors. Arch Pathol Lab Med 130:963–966.
OpenUrl PubMed

[10] Frankel WL

[11] ↵
Geers C,
Moulin P,
Gigot JF,
Weynand B,
Deprez P,
Rahier J,
et al.
(2006) Solid and pseudopapillary tumor of the pancreas--review and new insights into pathogenesis. Am J Surg Pathol 30:1243–1249.
OpenUrl CrossRef PubMed Web of Science

[12] Geers C,

[13] Moulin P,

[14] Gigot JF,

[15] Weynand B,

[16] Deprez P,

[17] Rahier J,

[18] et al.

[19] ↵
Chen G,
Liu S,
Zhao Y,
Dai M,
Zhang T
(2013) Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration for pancreatic cancer: a meta-analysis. Pancreatology 13:298–304.
OpenUrl

[20] Chen G,

[21] Liu S,

[22] Zhao Y,

[23] Dai M,

[24] Zhang T

[25] ↵
Abdelgawwad MS,
Alston E,
Eltoum IA
(2013) The frequency and cancer risk associated with the atypical cytologic diagnostic category in endoscopic ultrasound-guided fine-needle aspiration specimens of solid pancreatic lesions: a meta-analysis and argument for a Bethesda System for Reporting Cytopathology of the Pancreas. Cancer Cytopathol 121:620–628.
OpenUrl CrossRef PubMed

[26] Abdelgawwad MS,

[27] Alston E,

[28] Eltoum IA

[29] ↵
Ehehalt F,
Saeger HD,
Schmidt CM,
Grützmann R
(2009) Neuroendocrine tumors of the pancreas. Oncologist 14:456–467.
OpenUrl Abstract/FREE Full Text

[30] Ehehalt F,

[31] Saeger HD,

[32] Schmidt CM,

[33] Grützmann R

[34] ↵
Lepage C,
Bouvier AM,
Phelip JM,
Hatem C,
Vernet C,
Faivre J
(2004) Incidence and management of malignant digestive endocrine tumours in a well defined French population. Gut 53:549–553.
OpenUrl Abstract/FREE Full Text

[35] Lepage C,

[36] Bouvier AM,

[37] Phelip JM,

[38] Hatem C,

[39] Vernet C,

[40] Faivre J

[41] ↵
Puli SR,
Kalva N,
Bechtold ML,
Pamulaparthy SR,
Cashman MD,
Estes NC,
et al.
(2013) Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: a systematic review and meta analysis. World J Gastroenterol 19:3678–3684.
OpenUrl

[42] Puli SR,

[43] Kalva N,

[44] Bechtold ML,

[45] Pamulaparthy SR,

[46] Cashman MD,

[47] Estes NC,

[48] et al.

[49] ↵
Law JK,
Ahmed A,
Singh VK,
Akshintala VS,
Olson MT,
Raman SP,
et al.
(2014) A systematic review of solid-pseudopapillary neoplasms: are these rare lesions? Pancreas 43:331–337.
OpenUrl CrossRef PubMed

[50] Law JK,

[51] Ahmed A,

[52] Singh VK,

[53] Akshintala VS,

[54] Olson MT,

[55] Raman SP,

[56] et al.

[57] ↵
Li L,
Othman M,
Rashid A,
Wang H,
Li Z,
Katz MH,
et al.
(2013) Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells. Histopathology 62:465–471.
OpenUrl

[58] Li L,

[59] Othman M,

[60] Rashid A,

[61] Wang H,

[62] Li Z,

[63] Katz MH,

[64] et al.

[65] ↵
Jung WS,
Kim JK,
Yu JS,
Kim JH,
Cho ES,
Chung JJ
(2014) Comparison of abdominal ultrasonographic findings with endoscopic ultrasonographic findings of solid pseudopapillary neoplasms of the pancreas. Ultrasound Q 30:173–178.
OpenUrl

[66] Jung WS,

[67] Kim JK,

[68] Yu JS,

[69] Kim JH,

[70] Cho ES,

[71] Chung JJ

[72] ↵
Law JK,
Stoita A,
Wever W,
Gleeson FC,
Dries AM,
Blackford A,
et al.
(2014) Endoscopic ultrasound-guided fine needle aspiration improves the pre-operative diagnostic yield of solid-pseudopapillary neoplasm of the pancreas: an international multicenter case series (with video). Surg Endosc 28:2592–2598.
OpenUrl

[73] Law JK,

[74] Stoita A,

[75] Wever W,

[76] Gleeson FC,

[77] Dries AM,

[78] Blackford A,

[79] et al.

[80] ↵
Terris B,
Cavard C
(2014) Diagnosis and molecular aspects of solid-pseudopapillary neoplasms of the pancreas. Semin Diagn Pathol 31:484–490.
OpenUrl

[81] Terris B,

[82] Cavard C

[83] ↵
Jhala N,
Siegal GP,
Jhala D
(2008) Large, clear cytoplasmic vacuolation: an under-recognized cytologic clue to distinguish solid pseudopapillary neoplasms of the pancreas from pancreatic endocrine neoplasms on fine-needle aspiration. Cancer 114:249–254.
OpenUrl CrossRef PubMed

[84] Jhala N,

[85] Siegal GP,

[86] Jhala D

[87] ↵
Samad A,
Shah AA,
Stelow EB,
Alsharif M,
Cameron SE,
Pambuccian SE
(2013) Cercariform cells: another cytologic feature distinguishing solid pseudopapillary neoplasms from pancreatic endocrine neoplasms and acinar cell carcinomas in endoscopic ultrasound-guided fine-needle aspirates. Cancer Cytopathol 121:298–310.
OpenUrl

[88] Samad A,

[89] Shah AA,

[90] Stelow EB,

[91] Alsharif M,

[92] Cameron SE,

[93] Pambuccian SE

[94] ↵
Layfield LJ,
Ehya H,
Filie AC,
Hruban RH,
Jhala N,
Joseph L,
et al.
(2014) Utilization of ancillary studies in the cytologic diagnosis of biliary and pancreatic lesions: the Papanicolaou Society of Cytopathology guidelines for pancreatobiliary cytology. Diagn Cytopathol 42:351–362.
OpenUrl CrossRef PubMed

[95] Layfield LJ,

[96] Ehya H,

[97] Filie AC,

[98] Hruban RH,

[99] Jhala N,

[100] Joseph L,

[101] et al.

[102] ↵
Notohara K,
Hamazaki S,
Tsukayama C,
Nakamoto S,
Kawabata K,
Mizobuchi K,
et al.
(2000) Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and CD10. Am J Surg Pathol 24:1361–1371.
OpenUrl CrossRef PubMed Web of Science

[103] Notohara K,

[104] Hamazaki S,

[105] Tsukayama C,

[106] Nakamoto S,

[107] Kawabata K,

[108] Mizobuchi K,

[109] et al.

[110] ↵
Burford H,
Baloch Z,
Liu X,
Jhala D,
Siegal GP,
Jhala N
(2009) E-cadherin/beta-catenin and CD10: a limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreas. Am J Clin Pathol 132:831–839.
OpenUrl CrossRef PubMed

[111] Burford H,

[112] Baloch Z,

[113] Liu X,

[114] Jhala D,

[115] Siegal GP,

[116] Jhala N

[117] ↵
Adams AL,
Siegal GP,
Jhala NC
(2008) Solid pseudopapillary tumor of the pancreas: a review of salient clinical and pathologic features. Adv Anat Pathol 15:39–45.
OpenUrl CrossRef PubMed Web of Science

[118] Adams AL,

[119] Siegal GP,

[120] Jhala NC

[121] ↵
El-Bahrawy MA,
Rowan A,
Horncastle D,
Tomlinson I,
Theis BA,
Russell RC,
et al.
(2008) E-cadherin/catenin complex status in solid pseudopapillary tumor of the pancreas. Am J Surg Pathol 32:1–7.
OpenUrl CrossRef PubMed Web of Science

[122] El-Bahrawy MA,

[123] Rowan A,

[124] Horncastle D,

[125] Tomlinson I,

[126] Theis BA,

[127] Russell RC,

[128] et al.

[129] ↵
Scarpa A,
Mantovani W,
Capelli P,
Beghelli S,
Boninsegna L,
Bettini R,
et al.
(2010) Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients. Mod Pathol 23:824–833.
OpenUrl CrossRef PubMed Web of Science

[130] Scarpa A,

[131] Mantovani W,

[132] Capelli P,

[133] Beghelli S,

[134] Boninsegna L,

[135] Bettini R,

[136] et al.

[137] ↵
Franchi G,
Manzoni MF
(2014) Cytological Ki-67 in pancreatic endocrine tumors: a new “must”? Gland Surg 3:219–221.
OpenUrl PubMed

[138] Franchi G,

[139] Manzoni MF

[140] ↵
Hasegawa T,
Yamao K,
Hijioka S,
Bhatia V,
Mizuno N,
Hara K,
et al.
(2014) Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors. Endoscopy 46:32–38.
OpenUrl CrossRef PubMed

[141] Hasegawa T,

[142] Yamao K,

[143] Hijioka S,

[144] Bhatia V,

[145] Mizuno N,

[146] Hara K,

[147] et al.

[148] ↵
Vinayek R,
Capurso G,
Larghi A
(2014) Grading of EUS-FNA cytologic specimens from patients with pancreatic neuroendocrine neoplasms: it is time move to tissue core biopsy? Gland Surg 3:222–225.
OpenUrl

[149] Vinayek R,

[150] Capurso G,

[151] Larghi A

[152] ↵
Hooper K,
Mukhtar F,
Li S,
Eltoum IA
(2013) Diagnostic error assessment and associated harm of endoscopic ultrasound-guided fine-needle aspiration of neuroendocrine neoplasms of the pancreas. Cancer Cytopathol 121:653–660.
OpenUrl

[153] Hooper K,

[154] Mukhtar F,

[155] Li S,

[156] Eltoum IA

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Differential diagnosis between pancreatic neuroendocrine and solid pseudopapillary neoplasms on endoscopic ultrasound-guided fine-needle aspiration

An immunohistochemical study

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Differential diagnosis between pancreatic neuroendocrine and solid pseudopapillary neoplasms on endoscopic ultrasound-guided fine-needle aspiration

An immunohistochemical study

References

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