Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Genetic influence on circulating vitamin D among Saudi Arabians

Mir Sadat-Ali, Haifa A. Al-Turki, Mohammed Q. Azam and Abdulmohsen H. Al-Elq
Saudi Medical Journal September 2016, 37 (9) 996-1001; DOI: https://doi.org/10.15537/smj.2016.9.14700
Mir Sadat-Ali
1From the Departments of Orthopaedic Surgery (Sadat-Ali, Azam), Obstetrics and Gynecology (Al-Turki), Internal Medicine (Al-Elq), College of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Kingdom of Saudi Arabia.
MS, FRCS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Haifa A. Al-Turki
1From the Departments of Orthopaedic Surgery (Sadat-Ali, Azam), Obstetrics and Gynecology (Al-Turki), Internal Medicine (Al-Elq), College of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Kingdom of Saudi Arabia.
MBBS, SSC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mohammed Q. Azam
1From the Departments of Orthopaedic Surgery (Sadat-Ali, Azam), Obstetrics and Gynecology (Al-Turki), Internal Medicine (Al-Elq), College of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Kingdom of Saudi Arabia.
MBBS, MS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abdulmohsen H. Al-Elq
1From the Departments of Orthopaedic Surgery (Sadat-Ali, Azam), Obstetrics and Gynecology (Al-Turki), Internal Medicine (Al-Elq), College of Medicine, University of Dammam, King Fahd Hospital of the University, AlKhobar, Kingdom of Saudi Arabia.
MBBS, ABOG
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. ↵
    1. Chacko SA,
    2. Song Y,
    3. Manson JE,
    4. Van Horn L,
    5. Eaton C,
    6. Martin LW,
    7. et al.
    (2011) Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women. Am J Clin Nutr 94:209–217.
    OpenUrlAbstract/FREE Full Text
  2. ↵
    1. Reid IR
    (2015) What diseases are causally linked to vitamin D deficiency? Arch Dis Child 0:1–5.
  3. ↵
    1. Sadat-Ali M,
    2. Al-Elq AH,
    3. Al-Shaikh IH,
    4. Al-Turki HA,
    5. Al-Ali AK,
    6. Al-Othman AA
    (2014) Assessment of low vitamin D among Saudi Arabians. Did we overshoot the runway? Saudi Med J 35:1243–1249.
    OpenUrl
  4. ↵
    1. Holick MF
    (2007) Vitamin D deficiency. N Engl J Med 357:266–281.
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. Cheung CL,
    2. Lau KS,
    3. Sham PC,
    4. Tan KC,
    5. Kung AW
    (2013) Genetic variant in vitamin D binding protein is associated with serum 25-hydroxyvitamin D and vitamin D insufficiency in southern Chinese. J Hum Genet 58:749–751.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Engelman CD,
    2. Meyers KJ,
    3. Ziegler JT,
    4. Taylor KD,
    5. Palmer ND,
    6. Haffner SM,
    7. et al.
    (2010) Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study. J Steroid Biochem Mol Biol 122:186–192.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Wang TJ,
    2. Zhang F,
    3. Richards JB,
    4. Kestenbaum B,
    5. van Meurs JB,
    6. Berry D,
    7. et al.
    (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 17(376):180–188.
    OpenUrl
  8. ↵
    1. Ahn J,
    2. Yu K,
    3. Stolzenberg-Solomon R,
    4. Simon KC,
    5. McCullough ML,
    6. Gallicchio L,
    7. et al.
    (2010) Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 19:2739–2745.
    OpenUrlCrossRefPubMedWeb of Science
    1. McGrath JJ,
    2. Saha S,
    3. Burne TH,
    4. Eyles DW
    (2010) A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol 121:471–477.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    1. Ardawi MS,
    2. Qari MH,
    3. Rouzi AA,
    4. Maimani AA,
    5. Raddadi RM
    (2011) Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women. Osteoporos Int 22:463–475.
    OpenUrlCrossRefPubMed
  10. ↵
    1. ElSammak MY,
    2. Al-Wossaibi AA,
    3. Al-Howeish A,
    4. Alsaeed J
    (2010) Vitamin D deficiency in Saudi Arabs. Horm Metab Res 42:1–5.
    OpenUrlCrossRefPubMed
  11. ↵
    1. Al-Elq AM
    (2012) The status of Vitamin D in medical students in the preclerkship years of a Saudi medical school. J Family Community Med 19:100–104.
    OpenUrlPubMed
  12. ↵
    1. Li LH,
    2. Yin XY,
    3. Wu XH,
    4. Zhang L,
    5. Pan SY,
    6. Zheng ZJ,
    7. et al.
    (2014) Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese. Endocr J 61:133–141.
    OpenUrl
  13. ↵
    1. Coşkun S,
    2. Şimşek Ş,
    3. Camkurt MA,
    4. Çim A,
    5. Çelik SB
    (2016) Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder. Gene 588:109–114.
    OpenUrl
  14. ↵
    1. Pike JW,
    2. Meyer MB,
    3. Benkusky NA,
    4. Lee SM,
    5. St John H,
    6. Carlson A,
    7. et al.
    (2016) Genomic Determinants of Vitamin D-Regulated Gene Expression. Vitam Horm 100:21–44.
    OpenUrlCrossRef
  15. ↵
    1. Engelman CD,
    2. Fingerlin TE,
    3. Langefeld CD,
    4. Hicks PJ,
    5. Rich SS,
    6. Wagenknecht LE,
    7. et al.
    (2008) Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab 93:3381–388.
    OpenUrlCrossRefPubMedWeb of Science
  16. ↵
    1. Elkum F,
    2. Alkayal F,
    3. Noronha F,
    4. Ali MM,
    5. Melhem M,
    6. Al-Arouj M,
    7. et al.
    (2014) Vitamin D Insufficiency in Arabs and South Asians Positively Associates with Polymorphisms in GC and CYP2R1 Genes. PLOS one 18:e113102.
    OpenUrl
  17. ↵
    1. Nissen J,
    2. Rasmussen LB,
    3. Ravn-Haren G,
    4. Andersen EW,
    5. Hansen B,
    6. Andersen R,
    7. et al.
    (2014) Common Variants in CYP2R1 and GC Genes Predict Vitamin D Concentrations in Healthy Danish Children and Adults. PLoS One 27:e89907.
    OpenUrl
  18. ↵
    1. Robien K,
    2. Butler LM,
    3. Wang R,
    4. Beckman KB,
    5. Walek D,
    6. Koh W,
    7. et al.
    (2013) Genetic and environmental predictors of serum 25 hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore. British Journal of Nutrition 109:493–502.
    OpenUrlCrossRefPubMed
  19. ↵
    1. Slater NA,
    2. Rager ML,
    3. Havrda DE,
    4. Harralson AF
    (2015) Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status. J Pharm Pract 2:pii:0897190015585876.
  20. ↵
    1. Souberbielle JC,
    2. Body JJ,
    3. Lappe JM,
    4. Plebani M,
    5. Shoenfeld Y,
    6. Wang TJ,
    7. et al.
    (2010) Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Auto immun Rev 9:709–715.
    OpenUrl
  21. ↵
    1. Tagliabue E,
    2. Raimondi S,
    3. Gandini S
    (2015) Meta-analysis of Vitamin D-Binding Protein and Cancer Risk. Cancer Epidemiol Biomarkers Prev 24:1758–1765.
    OpenUrlAbstract/FREE Full Text
  22. ↵
    1. Nabi G,
    2. Hobani Y,
    3. Sarwat M
    (2015) High prevalence of vitamin D deficiency and cancer in Saudi Arabian populations: Can we hypothesize a link? Medical Hypotheses, 85:117–179.
  23. ↵
    1. Alghamdi IG,
    2. Hussain II,
    3. Alghamdi MS,
    4. El-Sheemy MA
    (2013) The incidence rate of female breast cancer in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001-2008. Breast Cancer (Dove Med Press) 17:103–109.
    OpenUrl
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 37 (9)
Saudi Medical Journal
Vol. 37, Issue 9
1 Sep 2016
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Genetic influence on circulating vitamin D among Saudi Arabians
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Genetic influence on circulating vitamin D among Saudi Arabians
Mir Sadat-Ali, Haifa A. Al-Turki, Mohammed Q. Azam, Abdulmohsen H. Al-Elq
Saudi Medical Journal Sep 2016, 37 (9) 996-1001; DOI: 10.15537/smj.2016.9.14700

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Genetic influence on circulating vitamin D among Saudi Arabians
Mir Sadat-Ali, Haifa A. Al-Turki, Mohammed Q. Azam, Abdulmohsen H. Al-Elq
Saudi Medical Journal Sep 2016, 37 (9) 996-1001; DOI: 10.15537/smj.2016.9.14700
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Hematological parameters in recent and past dengue infections in Jazan Province, Saudi Arabia
  • Longitudinal analysis of foodborne disease outbreaks in Saudi Arabia
  • Psychological stress and its association with bronchial asthma in Saudi Arabia
Show more Original Article

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire