The re-awakening of hCG expression. Its role in the diagnosis of cervical squamous cell carcinoma

IIllustration of immunohistochemical staining for hCG, demonstrating strong expression is related to squamous cell carcinoma (SCC). Panel a) weak immunohistochemical staining in high grade squamous intraepithelial lesions (HSIL) for human chorionic gonadotropin (hCG) (x100 photomicrograph); Panel b) weak immunohistochemical staining for hCG expression in high grade squamous intraepithelial lesions HSIL and adjacent NSE (x100 photomicrograph); Panel c) strong immunohistochemical staining for hCG expression in SCC, prominent at the periphery of the tumor (x40 photomicrograph); Panel d) strong, score 1 (1-10% of tumor cells) immunohistochemical staining for hCG expression (x100 photomicrograph); Panel e) strong, score 2 (50% of tumor cells) immunohistochemical staining for hCG expression (x200 photomicrograph); Panel f) strong, score 3 (≥50% of tumor cells) immunohistochemical staining for hCG (x200 photomicrograph).