Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Case ReportCase Report
Open Access

Fatal case of cerebral aspergilloma complicated by ventriculitis and bacteremia due to Salmonella species in a sickle cell disease patient

Fawzia E. Alotaibi
Saudi Medical Journal September 2018, 39 (9) 935-939; DOI: https://doi.org/10.15537/smj.2018.9.22821
Fawzia E. Alotaibi
From the Department of Pathology and Laboratory Medicine, College of Medicine, King Saud University and King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia
MD, MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

Abstract

To describe a fatal case of invasive Aspergillus flavus sinusitis in a 43-year old female with sickle cell disease (SCD) complicated by intracerebral aspergilloma and invasive Salmonella infection. Cerebral aspergilloma carries a very high mortality rate. The patient developed post-craniotomy intracerebral hemorrhage at the site of biopsy, Salmonella species sepsis and ventriculitis. She presented with a 2-month history of headache, dizziness, personality and behavioral changes, and vomiting. Initial clinical evaluation raised the suspicion of brain tumor. Brain magnetic resonance imaging revealed a left frontal, thick-walled ring-enhancing lesion with extensive surrounding edema suggestive of a neoplastic lesion, or a contiguous inflammatory or infectious process from the skull base. Despite early diagnosis and appropriate antifungal and surgical management, she eventually died from severe infection and respiratory arrest. In conclusion, invasive aspergillosis should be included in the differential diagnosis of SCD patients with central nervous system (CNS) lesions.

Cerebral aspergillosis, including infection of the sinuses is a serious infection and difficult to diagnose because it is usually misdiagnosed as tumor and is associated with high mortality.1,2 Surgical exploration and intra-operative diagnosis is required for accurate diagnosis and is made by histopathological examination.2 Early surgical intervention and aggressive antifungal treatment are considered as cornerstone management strategies.2 Aspergillosis of the sinuses is a spectrum of diseases that range from local infection involving the sinuses to invasive aspergillosis with extension to the brain and orbit.3,4 Invasive aspergillosis affects primarily immunocompromised hosts and rarely immunocompetent individuals.1-7 Causes of Immunosuppression such as hematological malignancies, prolonged neutropenia and solid organ transplant are among the recognized risk factors for invasive aspergillosis.1-6 Hematogenous dissemination of the infection to the brain or directly via the paranasal sinuses is associated with poor prognosis.3-7 Cerebral abscess and ventriculitis caused by Salmonella species as a postoperative complication of craniotomy associated with fungal infection are extremely rare. This report presents the challenge of postoperative infectious complications in patients presenting with cerebral aspergillosis. It describes an unusual case of invasive aspergillosis of the paranasal sinuses involving the brain in a sickle cell disease (SCD) patient who eventually died because of post-craniotomy Salmonella ventriculitis, abscess collections and severe brain edema. The rapid clinical progression and complications of invasive sinusitis presented in this case highlight the importance of early diagnosis and initiation of antifungal treatment in such cases. This is a case report of invasive aspergillosis in a SCD patient from the Middle East region.

Case Report

Patient information

A 43-year-old female, a known case of SCD, presented to the Emergency room with a 2-month history of headache, dizziness, personality and behavioral changes, and recurrent vomiting.

Clinical findings

Physical examination revealed an axillary temperature of 37.4°C; heart rate 156 bpm; respiratory rate 22 cpm; blood pressure 112/84 mmHg; and SpO2 99%. She was examined by the ear, nose, and throat (ENT) specialist, and endoscopic evaluation of the sinuses suggested that the sinuses was the source of infection.

Diagnostic assessment

Functional endoscopic sinus surgery was performed and endoscopic examination of the left nostril showed slough and dead tissue; pus was seen in the frontal sinus and the mucosa was unhealthy. During examination, she underwent debridement of the slough and dead tissue of the sphenoidal sinus, periorbita and septum mucosa. Local intranasal ceftriaxone and caspofungin were used during debridement of the sinuses. A brain computed tomography (CT) scan revealed a left frontal intra-axial thick-walled ring-enhancing lesion with extensive surrounding edema, possibly a high-grade neoplastic lesion (glioma) involving the corpus callosum, or a contiguous inflammatory or infectious process originating from the skull base. There were also bony and dural changes along the anterior skull base with erosion of the sella turcica and lateral sphenoid bone toward the cavernous sinus (Figure 1). Initial clinical and radiological evaluation raised the suspicion of a brain tumor. Based on clinical examination, the decision was to perform a craniotomy and excisional biopsy of the frontal lobe lesion for diagnostic and therapeutic purposes. The risks associated with the surgery included infection, bleeding, recollection of abscesses, and recurrence. During surgery, a neuronavigation-guided frozen section of the brain lesion was performed which was sent to the histopathology laboratory. The intraoperative diagnosis was left granulomatous invasive fungal sinusitis with erosion of the sella turcica and lateral sphenoid bone toward the cavernous sinus. A granuloma was observed histologically and a few days later, cultures from the brain lesion and nasal tissue yielded many septate branching fungal hyphae identified as Aspergillus flavus (Figure 2). The fungus was resistant to amphotericin B (minimum inhibitory concentration (MIC=2µg/mL), and susceptible to voriconazole (MIC=0.12µg/mL), itraconazole (MIC=0.12µg/mL) and posaconazole (MIC=0.06µg/mL). Aspergillus antigen test (galactomannan and IgG) yielded negative results. The final diagnoses, based on culture findings were invasive sinus aspergillosis and intracerebral aspergilloma.

Figure 1
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1

Post contrast administration MRI-Brain; A) Axial T1WI, A large mass lesion is noted in left frontal lobe, measuring about 6 x 5 cm. B) Axial T2WI, There is dural thickening and enhancement along the left cribriform plate, tuberculum sella and floor of sella. Mucosal thickening and abnormal density is noted in the sphenoid sinus and the left sphenoid sinus with well demarcated osseous defect on left side. C) Sagittal T1WI, bony and dural changes along the anterior skull base and left frontal intra-axial mass thick-walled ring enhancing lesion with extensive surrounding edema possibly aggressive neoplastic lesion, or less likely contiguous inflammatory or infectious process from skull base.

Figure 2
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 2

Photomicrograph of the brain lesion showing A) branched and septate fungal hyphae typical of aspergillosis in Grocott’s methenamine silver stain. B) aspergillus flavus conidiophore bearing vesicle (phialides arise circumferentially from the globose vesicle) in Lactophenol cotton blue (LPCB).

Therapeutic intervention

Unfortunately, diagnostic endonasal sinus debridement was incomplete due to extensive infection that might spread to involve the cavernous sinus on aggressive management. Therefore, she underwent surgery (craniotomy) and repeated debridements were also carried out. Post-operatively, she tolerated the operation well, she was intubated and transferred to the surgical intensive care unit for observation and started on antifungal medication voriconazole (600 mg/day) and caspofungin (70 mg/day IV) and (50 mg/day IV) thereafter.

Follow up and outcomes

She was afebrile, she had no basal discharge, she could move all limbs and was taking orally. Her Glasgow coma scale (GCS) score was 15/15 with no focal neurological deficit. The wound was clean and dry. She received cefazolin, dexamethasone, haloperidol (2.5 mg, IM, q6hr), metoclopramide (10 mg, q8hr), and phenytoin (100 mg, IV, q8hr). In the context of her clinical condition, vasculitis screening for antineutrophil cytoplasmic antibodies, antinuclear antibody, HIV test and CD4 count was requested. The results revealed reduced levels of IgG and IgM. Consultation with an immunologist suggested that the low immunoglobulin level could explain her underlying fungal infection. Seven days after surgery she showed decreased level of consciousness due to intracerebral hemorrhage at the biopsy site and sepsis caused by Gram-negative bacilli. She became febrile, tachycardic, and had leukocytosis (white blood cell [WBC] count, 12.34×109/L). She was evaluated by the infectious diseases and ENT specialists. Her renal function tests showed high creatinine (150 µmol/L) and blood urea nitrogen levels. Because of her new symptoms, she underwent a second craniotomy which revealed subgaleal, left epidural and subdural and intraventricular abscesses that were evacuated and irrigated thoroughly. Pure pus drained after insertion of an external ventricular drain in the right frontal abscess. Specimens were collected during surgery and pus from abscesses and tissue samples were sent for culture and histopathology. Cerebrospinal fluid (CSF) analysis showed a red blood cell count of 50/mm3 and WBC 700×106/L (90% polymorphs and 10% mononuclear cells). All cultures of specimens including blood, stool, CSF, brain abscess, and scalp wound yielded ampicillin and ciprofloxacin-resistant (MIC=0.094 µg/mL, Nalidixic Acid=R) group B Salmonella species. Intravenous (IV) ceftriaxone (2 g) 12-hourly was started. A brain CT scan showed purulent fluid, edema with subsequent mass effect on the frontal horn of the lateral ventricles and a small suspicious communication with the left frontal horn and abscess collection in the left lateral ventricle with mild enhancement of the ventricular outlines suggestive of ventriculitis (Figure 3). The patient developed seizures triggered by sepsis and neuroleptics. Her clinical condition deteriorated over time due to Salmonella sepsis and ventriculitis, renal impairment, malnutrition, pancytopenia and high risk of aspiration pneumonia. She was intubated, drowsy (GCS: 11/15), moved all 4 limbs, grasped both hands on command, and had symmetric and reactive pupils. She exhibited convulsive movements of the left eyelids and right distal foot. Despite aggressive management, the patient died due to severe infection and respiratory arrest. A timeline table showing the progress of the patient since admission and throughout the hospitalization course is shown in (Table 1).

Figure 3
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 3

Postoperative MRI-Brain. Complex signal abnormality noted at the surgical bed at bifrontal (A) and (B), region most likely representing subacute blood, some purulent fluid, pneumocephalus and edema with possible communication with the left lateral ventricle (C) and (D). No brain infarction or venous sinus thrombosis.

View this table:
  • View inline
  • View popup
  • Download powerpoint
Table 1

A timeline table showing the progress of the patient since admission and throughout the hospitalization course.

Discussion

Invasive aspergillosis is a fatal infection that commonly affects immunocompromised hosts. Individuals at the highest risk of acquiring invasive aspergillosis include patients with leukemia during induction therapy; solid organ transplant, prolonged neutropenia, immunodeficiency, and corticosteroid use.1-3 Invasive aspergillosis is rare in immunocompetent individuals.5-7

Although no clear association exists in the literature between SCD and invasive aspergillosis, SCD is suggested to have contributed to the pathogenesis of invasive aspergillosis in the present case. In addition, her underlying hematological disease combined with the incomplete sinus debridement, Intensive care unit admission, and surgical interventions triggered a complicated clinical course including intracerebral aspergilloma and Gram-negative Salmonella bacteremia. Additionally, multiple catheterization, abnormal renal function and mechanical ventilation might have adversely affected the immune function and led to the poor outcome.

The most frequent symptoms in patients with Central Nervous System (CNS) aspergillosis are headache, vomiting, convulsions, fever, and cranial nerve paralysis. Our patient presented mainly with prolonged headache and dizziness. This suggests that in SCD patients, such history should raise the clinical suspicion of possible fungal infection caused by Aspergillus species. In addition, environmental factors including airborne mold concentrations, geographic location, and constructional work may influence IA development.8

An interesting magnetic resonance imaging finding in this case is the observation of irregularity and mild narrowing of the arteries of the circle of Willis, including the terminal internal carotid, proximal middle cerebral, anterior cerebral and posterior cerebral arteries due to the patient’s SCD. We proposed that might be the reason for the rapid progression and invasiveness of the fungal infection in this case.

Voriconazole, isavuconazole and amphotericin B are the antifungal agents used for the first-line treatment of IA.9,10 Caspofungin have been shown to exert in vitro and in vivo activity against Aspergillus spp and is approved for the treatment of IA in patients who are intolerant to first-line therapy.9 Our patient was treated with voriconazole and caspofungin. Combination therapy with voriconazole and caspofungin in treatment of CNS aspergillosis is promosing.10 However, we believe that, the severity of infection, coinfection with Salmonella ventriculitis and sepsis contribute to the poor outcome in this patient.

In conclusion, invasive aspergillosis should be included in the differential diagnosis of SCD patients with CNS lesions, particularly if presented with chronic symptoms suggestive of CNS involvement. Rapid diagnosis and aggressive medical and surgical management are of the utmost importance.

Acknowledgment

We would like to thank Editage (http://www.editage.com/) for English language editing.

Footnotes

  • Disclosure. Authors have no conflict of interests, and the work was not supported or funded by any drug company.

  • Received May 6, 2018.
  • Accepted July 25, 2018.
  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

  1. ↵
    1. Taccone FS,
    2. Van den Abeele AM,
    3. Bulpa P,
    4. Misset B,
    5. Meersseman W,
    6. Cardoso T,
    7. et al.
    (2015) Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes. Crit Care 19:7.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Alsalman J,
    2. Zaid T,
    3. Makhlooq M,
    4. Madan M,
    5. Mohamed Z,
    6. Alarayedh A
    (2017) A retrospective study of the epidemiology and clinical manifestation of invasive aspergillosis in a major tertiary care hospital in Bahrain. J Infect Public Health 10:49–58.
    OpenUrl
  3. ↵
    1. Baeesa SS,
    2. Bokhari RF,
    3. Alghamdi KB,
    4. Alem HB,
    5. Al-Maghrabi JA,
    6. Madani TA
    (2017) Invasive aspergillus sinusitis with orbitocranial extension. Asian J Neurosurg 12:172–179.
    OpenUrl
  4. ↵
    1. Jariwal R,
    2. Heidari A,
    3. Sandhu A,
    4. Patel J,
    5. Shoaepour K,
    6. Natarajan P,
    7. et al.
    (2018) Granulomatous Invasive Aspergillus flavus Infection Involving the Nasal Sinuses and Brain. J Investig Med High Impact Case Rep 6:2324709618770473.
  5. ↵
    1. Ahmadzai H,
    2. Raley DA,
    3. Masters L,
    4. Davies M
    (2013) An unusual case of a pituitary fossa aspergilloma in an immunocompetent patient mimicking infiltrative tumour. J Surg Case Rep 2013:rjt018.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Ouyang T,
    2. Zhang N,
    3. Wang L,
    4. Jiao J,
    5. Zhao Y,
    6. Li Z,
    7. et al.
    (2015) Primary Aspergillus sellar abscess simulating pituitary tumor in immunocompetent patient. J Craniofac Surg 26:e86–e88.
    OpenUrl
  7. ↵
    1. Bangash M
    (2017) Aspergillus flavus Brain Abscess in Immunocompetent Teenagers: A Case Series with Review of Literature. Journal of Case Reports 7:8–12.
    OpenUrl
  8. ↵
    1. Garcia-Vidal C,
    2. Peghin M,
    3. Cervera C,
    4. Gudiol C,
    5. Ruiz-Camps I,
    6. Moreno A,
    7. et al.
    (2015) Causes of death in a contemporary cohort of patients with invasive aspergillosis. PLoS One 10:e0120370.
    OpenUrl
  9. ↵
    1. Patterson TF,
    2. Thompson GR 3rd.,
    3. Denning DW,
    4. Fishman JA,
    5. Hadley S,
    6. Herbrecht R,
    7. et al.
    (2016) Practice Guidelines for the Diagnosis and Management of Aspergillosis:2016 Update by the Infectious Diseases Society of America. Clin Infect Dis 63:e1–e60.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Bassetti M,
    2. Peghin M,
    3. Vena A
    (2018) Challenges and Solution of Invasive Aspergillosis in Non-neutropenic Patients: A Review. Infect Dis Ther 7:17–27.
    OpenUrl
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 39 (9)
Saudi Medical Journal
Vol. 39, Issue 9
1 Sep 2018
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Fatal case of cerebral aspergilloma complicated by ventriculitis and bacteremia due to Salmonella species in a sickle cell disease patient
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Fatal case of cerebral aspergilloma complicated by ventriculitis and bacteremia due to Salmonella species in a sickle cell disease patient
Fawzia E. Alotaibi
Saudi Medical Journal Sep 2018, 39 (9) 935-939; DOI: 10.15537/smj.2018.9.22821

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Fatal case of cerebral aspergilloma complicated by ventriculitis and bacteremia due to Salmonella species in a sickle cell disease patient
Fawzia E. Alotaibi
Saudi Medical Journal Sep 2018, 39 (9) 935-939; DOI: 10.15537/smj.2018.9.22821
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Case Report
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Cutaneous metastasis of signet ring cell adenocarcinoma of the colon
  • Giant left gastric artery aneurysm with intrathoracic extension
  • A rare case of a horseshoe kidney with a single left-sided ureter presented with recurrent urinary tract infection
Show more Case Report

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire