Research ArticleOriginal Article
Open Access

Prediction of squamous cell carcinoma cases from squamous cell hyperplasia in throat lesions using CT radiomics model

Osama A. Khodrog, Fengzhi Cui, Nannan Xu, Qinghe Han, Jianhua Liu, Tingting Gong and Qinghai Yuan
Saudi Medical Journal March 2021, 42 (3) 284-292; DOI: https://doi.org/10.15537/smj.2021.42.3.20200617

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    - Flowchart representing the patient selection criteria process. SCH: squamous cell hyperplasia, SCC: squamous cell carcinoma (SCC)

  • Figure 2
    Figure 2

    - The segmentation process by ITK-SNAP software for squamous cell carcinoma showing A-C) malignant and D-G) the squamous cell hyperplasia benign.

  • Figure 3
    Figure 3

    - Box plot of area-under-the-curve (AUC) values for throat cancer illustrating the higher values of computed tomography normal (CTN) parameters as compared to computed tomography artery (CTA) and computed tomography venous (CTV).

  • Figure 4
    Figure 4

    - The least absolute shrinkage and selection operator (LASSO) features after univariate logistic regression and removing redundancies, for each parameter was used in our study. A) The right and left image of compared to computed tomography artery (CTA), B) the right and left image of computed tomography normal (CTN), C) the right and left image of computed tomography venous (CTV).

Tables

  • Table 1

    - The performance of the CT parameters based on the radiomics model.

    CT parametersTraining dataTesting data
    Acc.Sen.Spe.PPV.NPV.Acc.Sen.Spe.PPV.NPV.
    CTA0.910.920.90.930.90.780.930.00.830.0
    CTN0.930.930.9330.950.900.840.940.330.880.50
    CTV0.920.970.870.910.960.780.75110.43

    • CTA: computed tomography artery, CTV: computed tomography venous, CTN: computed tomography normal, Acc: accuracy, Sen: sensitivity, Spe: specificity, PPV: positive predictive value, NPV: negative predictive value

  • Table 2

    - The statistically significant for least absolute shrinkage and selection operator (LASSO) features selected of throat cancer for each parameter used in this study.

    ModelTraining cohort (p-value)Validation cohort (p-value)
    CTA<0.000*0.014*
    CTN<0.000*<0.008*
    CTV<0.000*<0.002*

    • ↵* p-value is determined by the Spearman’s rank correlation test and p<0.05 is statistically significant. CTA: computed tomography artery, CTV: computed tomography venous, CTN: computed tomography normal

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