Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Vascular cell adhesion molecule-1 in rheumatoid arthritis patients

Relation to disease activity, oxidative stress, and systemic inflammation

Heba R. Salem and Enas S. Zahran
Saudi Medical Journal June 2021, 42 (6) 620-628; DOI: https://doi.org/10.15537/smj.2021.42.6.20200753
Heba R. Salem
From the Medical Physiology Department (Salem), and from Internal Medicine Department (Zahran), Immunology & Rheumatology Unit, Faculty of Medicine, Menoufia University, Egypt.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Enas S. Zahran
From the Medical Physiology Department (Salem), and from Internal Medicine Department (Zahran), Immunology & Rheumatology Unit, Faculty of Medicine, Menoufia University, Egypt.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Das S,
    2. Padhan P.
    An overview of the extraarticular involvement in rheumatoid arthritis and its management. J Pharmacol Pharmacother 2017; 8: 81.
    OpenUrlPubMed
  2. 2.↵
    1. Lee KS,
    2. Kronbichler A,
    3. Eisenhut M,
    4. Lee KH,
    5. Shin JI.
    Cardiovascular involvement in systemic rheumatic diseases: an integrated view for the treating physicians. Autoimmun Rev 2018; 17: 201–214.
    OpenUrlPubMed
  3. 3.↵
    1. Hannawi S,
    2. Hannawi H,
    3. Al Salmi I.
    Cardiovascular disease and subclinical atherosclerosis in rheumatoid arthritis. Hypertension Research 2020; 43: 982–984.
    OpenUrl
  4. 4.↵
    1. Reiss AB,
    2. Silverman A,
    3. Khalfan M,
    4. Vernice NA,
    5. Kasselman LJ,
    6. Carsons SE, et al.
    Accelerated atherosclerosis in rheumatoid arthritis: Mechanisms and treatment. Curr Pharm Des 2019; 25: 969–986.
    OpenUrl
  5. 5.↵
    1. Mahmoudi M,
    2. Aslani S,
    3. Fadaei R,
    4. Jamshidi AR.
    New insights to the mechanisms underlying atherosclerosis in rheumatoid arthritis. Int J Rheum Dis 2017; 20: 287–297.
    OpenUrl
  6. 6.↵
    1. Bergholm R,
    2. Leirisalo-Repo M,
    3. Vehkavaara S,
    4. Mäkimattila S,
    5. Taskinen M-R,
    6. Yki-Järvinen H.
    Impaired responsiveness to NO in newly diagnosed patients with rheumatoid arthritis. Arterioscler Thromb Vasc Biol 2002; 22: 1637–1641.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Totoson P,
    2. Maguin-Gaté K,
    3. Nappey M,
    4. Wendling D,
    5. Demougeot C.
    Endothelial dysfunction in rheumatoid arthritis: mechanistic insights and correlation with circulating markers of systemic inflammation. PloS One 2016; 11: e0146744.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Edlinger C,
    2. Lichtenauer M,
    3. Wernly B,
    4. Pistulli R,
    5. Paar V,
    6. Prodinger C, et al.
    Disease-specific characteristics of vascular cell adhesion molecule-1 levels in patients with peripheral artery disease. Heart Vessels 2019; 34: 976–983.
    OpenUrl
  9. 9.↵
    1. Lopez-Vilchez I,
    2. Diaz-Ricart M,
    3. Navarro V,
    4. Torramade S,
    5. Zamorano-Leon J,
    6. Lopez-Farre A, et al.
    Endothelial damage in major depression patients is modulated by SSRI treatment, as demonstrated by circulating biomarkers and an in vitro cell model. Transl Psychiatry 2016; 6: e886.
    OpenUrl
  10. 10.↵
    1. Schlesinger M,
    2. Bendas G.
    Vascular cell adhesion molecule-1 (VCAM-1)-An increasing insight into its role in tumorigenicity and metastasis. Int J Cancer 2015; 136: 2504–2514.
    OpenUrl
  11. 11.↵
    1. Cook-Mills JM,
    2. Marchese ME,
    3. Abdala-Valencia H.
    Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid Redox Signal 2011; 15: 1607–1638.
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.↵
    1. Alunno A,
    2. Carubbi F,
    3. Giacomelli R,
    4. Gerli R.
    Cytokines in the pathogenesis of rheumatoid arthritis: new players and therapeutic targets. BMC Rheumatol 2017; 1: 1–13.
    OpenUrl
  13. 13.↵
    1. Quiñonez-Flores CM,
    2. González-Chávez SA,
    3. Del Río Nájera D,
    4. Pacheco-Tena C.
    Oxidative stress relevance in the pathogenesis of the rheumatoid arthritis: a systematic review. Biomed Res Int 2016; 2016: 6097417.
    OpenUrl
  14. 14.↵
    1. Castañeda S,
    2. Nurmohamed MT,
    3. González-Gay MA.
    Cardiovascular disease in inflammatory rheumatic diseases. Best Pract Res Clin Rheumatol 2016; 30: 851–869.
    OpenUrlCrossRef
  15. 15.↵
    1. Aletaha D,
    2. Neogi T,
    3. Silman AJ,
    4. Funovits J,
    5. Felson DT,
    6. Bingham Iii CO, et al.
    2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62: 2569–2581.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. McWilliams DF,
    2. Kiely PD,
    3. Young A,
    4. Joharatnam N,
    5. Wilson D,
    6. Walsh DA.
    Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis. BMC Rheumatol 2018; 2: 1–12.
    OpenUrl
  17. 17.↵
    1. Dobiás-ová M,
    2. Frohlich J.
    The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma (FERHDL). Clin Biochem 2001; 34: 583–588.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Boo S,
    2. Oh H,
    3. Froelicher ES,
    4. Suh C-H.
    Knowledge and perception of cardiovascular disease risk among patients with rheumatoid arthritis. PloS One 2017; 12: e0176291.
    OpenUrl
  19. 19.↵
    1. England BR,
    2. Thiele GM,
    3. Anderson DR,
    4. Mikuls TR.
    Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications. BMJ 2018; 361: k1036.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Kong D-H,
    2. Kim YK,
    3. Kim MR,
    4. Jang JH,
    5. Lee S.
    Emerging roles of vascular cell adhesion molecule-1 (VCAM-1) in immunological disorders and cancer. Int J Mol Sci 2018; 19: 1057.
    OpenUrlCrossRef
  21. 21.↵
    1. Anyfanti P,
    2. Triantafyllou A,
    3. Gkaliagkousi E,
    4. Triantafyllou G,
    5. Koletsos N,
    6. Chatzimichailidou S, et al.
    Subendocardial viability ratio in patients with rheumatoid arthritis: comparison with healthy controls and identification of prognostic factors. Clin Rheumatol 2017; 36: 1229–1236.
    OpenUrl
  22. 22.↵
    1. Södergren A,
    2. Karp K,
    3. Bengtsson C,
    4. Möller B,
    5. Rantapää-Dahlqvist S,
    6. Wållberg-Jonsson S.
    Biomarkers associated with cardiovascular disease in patients with early rheumatoid arthritis. PloS One 2019; 14: e0220531.
    OpenUrl
  23. 23.↵
    1. Denys A,
    2. Clavel G,
    3. Lemeiter D,
    4. Schischmanoff O,
    5. Boissier M-C,
    6. Semerano L.
    Aortic VCAM-1: an early marker of vascular inflammation in collagen-induced arthritis. J Cell Mol Med 2016; 20: 855–863.
    OpenUrlCrossRefPubMed
  24. 24.↵
    1. Galkina E,
    2. Ley K.
    Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 2007; 27: 2292–301.
    OpenUrlAbstract/FREE Full Text
  25. 25.↵
    1. Steyers CM,
    2. Miller FJ.
    Endothelial dysfunction in chronic inflammatory diseases. Int J Mol Sci 2014; 15: 11324–1149.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Denys A,
    2. Clavel G,
    3. Lemeiter D,
    4. Schischmanoff O,
    5. Boissier MC,
    6. Semerano L.
    Aortic VCAM-1: an early marker of vascular inflammation in collagen induced arthritis. J Cell Mol Med 2016; 20: 855–863.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Hidayat R,
    2. Isbagio H,
    3. Alwi I,
    4. Soewondo P,
    5. Setiabudy R,
    6. Jusman SW, et al.
    The effect of hydroxychloroquine on endothelial dysfunction in patients with rheumatoid arthritis: A doubleblind randomized clinical trial. Int J Clin Rheumtol 2019; 14: 59.
    OpenUrl
  28. 28.↵
    1. Smith M,
    2. Slavotinek J,
    3. Au V,
    4. Weedon H,
    5. Parker A,
    6. Coleman M, et al.
    Successful treatment of rheumatoid arthritis is associated with a reduction in synovial membrane cytokines and cell adhesion molecule expression. Rheumatology 2001; 40: 965–977.
    OpenUrlCrossRefPubMedWeb of Science
  29. 29.↵
    1. Low AS,
    2. Symmons DP,
    3. Lunt M,
    4. Mercer LK,
    5. Gale CP,
    6. Watson KD, et al.
    Relationship between exposure to tumour necrosis factor inhibitor therapy and incidence and severity of myocardial infarction in patients with rheumatoid arthritis. Ann Rheum Dis 2017; 76: 654–660.
    OpenUrlAbstract/FREE Full Text
  30. 30.↵
    1. Oberoi R,
    2. Schuett J,
    3. Schuett H,
    4. Koch A-K,
    5. Luchtefeld M,
    6. Grote K, et al.
    Targeting tumor necrosis factor-α with adalimumab: effects on endothelial activation and monocyte adhesion. PLoS One 2016; 11: e0160145.
    OpenUrl
  31. 31.↵
    1. Lee JL,
    2. Sinnathurai P,
    3. Buchbinder R,
    4. Hill C,
    5. Lassere M,
    6. March L.
    Biologics and cardiovascular events in inflammatory arthritis: a prospective national cohort study. Arthritis Res Ther 2018; 20: 1–9.
    OpenUrlPubMed
  32. 32.↵
    1. Davies R,
    2. Iacono D,
    3. Jordan L,
    4. Williams J,
    5. Rawlings C,
    6. Lang D, et al.
    Serum vascular cell adhesion molecule-1 (VCAM-1) levels are associated with vascular dysfunction and increased cardiovascular risk in an animal model and patients with rheumatoid arthritis: Abstract Number: 1575. Arthritis & Rheumatology 2015; 67: 1965–1967.
    OpenUrl
  33. 33.↵
    1. Batún JG,
    2. Olan F,
    3. Hernández ÉN.
    Dyslipidemia and atherogenic risk in patients with rheumatoid arthritis. Clin Investig Arterioscler 2016; 28: 123–131.
    OpenUrl
  34. 34.↵
    1. Dhonthula R,
    2. Ram T.
    Study of Dyslipidemia and Cardio vascular risk in rheumatoid arthritis patients. Indian J Public Health Res Dev 2019; 10: 160–163.
    OpenUrl
  35. 35.↵
    1. Fonseca LJSd,
    2. Nunes-Souza V,
    3. Goulart MOF,
    4. Rabelo LA
    . Oxidative stress in rheumatoid arthritis: What the future might hold regarding novel biomarkers and add-on therapies. Oxid Med Cell Longev 2019; 2019: 7536805.
  36. 36.↵
    1. Das DC,
    2. Jahan I,
    3. Uddin MG,
    4. Hossain MM,
    5. Chowdhury MAZ,
    6. Fardous Z, et al.
    Serum CRP, MDA, Vitamin C, and trace elements in Bangladeshi patients with rheumatoid arthritis. Biol Trace Elem Res 2021; 199: 76–84.
    OpenUrl
  37. 37.↵
    1. England BR,
    2. Duryee MJ,
    3. Roul P,
    4. Mahajan TD,
    5. Singh N,
    6. Poole JA, et al.
    Malondialdehyde-Acetaldehyde Adducts and Antibody Responses in Rheumatoid Arthritis-Associated Interstitial Lung Disease. Arthritis Rheumatol 2019; 71: 1483–1493.
    OpenUrl
  38. 38.↵
    1. Zhou L,
    2. Feng J-T,
    3. Zhang L,
    4. Kuang Y.
    Clinical significance of serum total oxidant/antioxidant status for the disease activity in active rheumatoid arthritis. Int J Clin Exp Pathol. 2017;10(8):8895.
    OpenUrl
  39. 39.↵
    1. Mititelu RR,
    2. Pădureanu R,
    3. Băcănoiu M,
    4. Pădureanu V,
    5. Docea AO,
    6. Calina D, et al.
    Inflammatory and oxidative stress markers-mirror tools in rheumatoid arthritis. Biomedicines 2020; 8: 125.
    OpenUrl
  40. 40.↵
    1. Steven S,
    2. Frenis K,
    3. Oelze M,
    4. Kalinovic S,
    5. Kuntic M,
    6. Bayo Jimenez MT, et al.
    Vascular inflammation and oxidative stress: major triggers for cardiovascular disease. Oxid Med Cell Longev 2019; 23; 2019.
    OpenUrl
  41. 41.↵
    1. Steven S,
    2. Frenis K,
    3. Oelze M,
    4. Kalinovic S,
    5. Kuntic M,
    6. Bayo Jimenez MT, et al.
    Vascular inflammation and oxidative stress: Major triggers for cardiovascular disease. Oxid Med Cell Longev 2019; 2019: 7092151.
    OpenUrlCrossRef
  42. 42.↵
    1. Bordy R,
    2. Totoson P,
    3. Prati Cm,
    4. Marie C,
    5. Wendling D,
    6. Demougeot Cl
    . Microvascular endothelial dysfunction in rheumatoid arthritis. Nat Rev Rheumatol 2018; 14: 404–420.
    OpenUrlCrossRefPubMed
  43. 43.↵
    1. Grönwall C,
    2. Amara K,
    3. Hardt U,
    4. Krishnamurthy A,
    5. Steen J,
    6. Engström M, et al.
    Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis. J Autoimmun 2017; 84: 29–45.
    OpenUrlPubMed
  44. 44.↵
    1. Orr CK,
    2. Najm A,
    3. Young F,
    4. McGarry T,
    5. Biniecka M,
    6. Fearon U, et al.
    The utility and limitations of CRP, ESR and DAS28-CRP in appraising disease activity in rheumatoid arthritis. Front Med 2018; 5: 185.
    OpenUrl
  45. 45.↵
    1. Serkova VK,
    2. Pavlov SV,
    3. Romanava VA,
    4. Monastyrskiy YI,
    5. Ziepko SM,
    6. Kuzminova NV, et al.
    Medical expert system for assessment of coronary heart disease destabilization based on the analysis of the level of soluble vascular adhesion molecules. (Proceedings). Wilga (PL): Photonics Applications in Astronomy, Communications, Industry, and High Energy Physics Experiments; 2017.
  46. 46.↵
    1. Habas K,
    2. Shang L.
    Alterations in intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in human endothelial cells. Tissue Cell 2018; 54: 139–143.
    OpenUrl
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 42 (6)
Saudi Medical Journal
Vol. 42, Issue 6
1 Jun 2021
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Vascular cell adhesion molecule-1 in rheumatoid arthritis patients
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Vascular cell adhesion molecule-1 in rheumatoid arthritis patients
Heba R. Salem, Enas S. Zahran
Saudi Medical Journal Jun 2021, 42 (6) 620-628; DOI: 10.15537/smj.2021.42.6.20200753

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Vascular cell adhesion molecule-1 in rheumatoid arthritis patients
Heba R. Salem, Enas S. Zahran
Saudi Medical Journal Jun 2021, 42 (6) 620-628; DOI: 10.15537/smj.2021.42.6.20200753
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Comment on: Vascular cell adhesion molecule-1 in rheumatoid arthritis
  • Google Scholar

More in this TOC Section

  • Psychological stress and its association with bronchial asthma in Saudi Arabia
  • The factors affecting comfort and the comfort levels of patients hospitalized in the coronary intensive care unit
  • Exploring communication challenges with children and parents among pharmacists in Saudi Arabia
Show more Original Article

Similar Articles

Keywords

  • VCAM-1
  • endothelial dysfunction
  • oxidative stress
  • rheumatoid arthritis

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire