Article Figures & Data
Figures
- Figure 1
- Linear regression lines demonstrating the correlation of BMI with (a) estrogen during the follicular phase, (b) progesterone during the follicular phase, and (c) Migraine pain intensity by the visual analog scale.
Tables
- Table 1
- Comparison of the general characteristics and the hormonal levels between the migraineurs of MM, NMM migraine types and the controls during the follicular and luteal phases using ANOVA and LSD post hoc test.
Characteristics Control (n=21) MM (n=9) P-value1 NMM (n=5) P-value2 Mean±SD Mean±SD Mean±SD Age (years) 21.83±2.02 21.76±2.73 0.936 22.36±4.48 0.596 Body weight (Kg) 56.59±10.95 58.44±7.08 0.596 65.55±15.68* 0.027 BMI 21.78±4.24 22.60±2.55 0.552 25.77±6.53* 0.013 Follicular phase estrogen (pg/ml) 11.96±4.68 8.88±5.56 0.379 30.00±19.60** <0.001 Luteal phase estrogen (pg/ml) 25.18±13.17 21.41±15.36 0.506 39.79±11.45* 0.037 Follicular phase progesterone (ng/ml) 2.90±1.11 2.82±1.64 0.927 4.20±4.77 0.232 Luteal phase progesterone (ng/ml) 8.29±4.56 7.36±5.56 0.619 10.63±2.45 0.299 Follicular phase testosterone (ng/ml) 0.91±0.28 1.00±0.32 0.549 1.14±0.68 0.226 Luteal phase testosterone (ng/ml) 0.83±0.26 1.10±0.31* 0.023 0.60±0.22 0.089 MM - menstrually related, NMM - non-menstrual related, ANOVA - analysis of variance, LSD - least significant difference, BMI - body mass index, SD - standard deviation. P-value1 reflects the level of significance of LSD test comparing MM to the controls, P-value2 reflects the level of significance of LSD test comparing NMM to the controls. * p<0.05, ** p<0.001.
- Table 2
- Comparison of the sex hormone levels during the actual attacks of follicular versus luteal onset. (using independent samples student t-test).
Sex hormone levels Migraineurs with follicular onset (n=9) Migraineurs with luteal onset (n=5) P-value Mean±SD Mean±SD Follicular phase Estrogen (pg/ml) 16.41±14.23 16.41±21.56 1.000 Luteal phase Estrogen (pg/ml) 32.49±14.07 13.96±7.88* 0.036 Follicular phase Progesterone (ng/ml) 3.97±3.39 1.68±0.38 0.213 Luteal phase Progesterone (ng/ml) 9.93±4.56 5.21±2.49 0.087 Follicular phase Testosterone (ng/ml) 1.10±0.49 0.94±0.43 0.609 Luteal phase Testosterone (ng/ml) 0.96±0.35 0.96±0.35 0.964 SD - standard deviation.
* p<0.05,
↵** p<0.001.
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