Research ArticleOriginal Article
Open Access

The impact of emergency antibiotic administration time on patients with sepsis

Saqer M. Althunayyan, Mohammed A. Aljanoubi, Sultan M. Alghadeer, Musab Z. Alharthi, Raied N. Alotaibi, Abdullah M. Mubarak and Abdulaziz M. Almutary
Saudi Medical Journal September 2021, 42 (9) 1002-1008; DOI: https://doi.org/10.15537/smj.2021.42.9.20210447

References

  1. 1.↵
    1. Singer M,
    2. Deutschman CS,
    3. Seymour CW,
    4. Shankar-Hari M,
    5. Annane D,
    6. Bauer M, et al.
    The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016; 315: 801–810.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Saria S,
    2. Henry KE.
    Too many definitions of sepsis: can machine learning leverage the electronic health record to increase accuracy and bring consensus? Crit Care Med 2020; 48: 137–141.
    OpenUrl
  3. 3.↵
    1. Rudd KE,
    2. Johnson SC,
    3. Agesa KM,
    4. Shackelford KA,
    5. Tsoi D,
    6. Kievlan DR, et al.
    Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study. Lancet 2020; 395: 200–211.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Sakr Y,
    2. Jaschinski U,
    3. Wittebole X,
    4. Szakmany T,
    5. Lipman J,
    6. Ñamendys-Silva SA, et al.
    , editors. Sepsis in intensive care unit patients: worldwide data from the intensive care over nations audit. Open Forum Infect Dis 2018; 5: ofy313.
  5. 5.↵
    1. Levy MM,
    2. Artigas A,
    3. Phillips GS,
    4. Rhodes A,
    5. Beale R,
    6. Osborn T, et al.
    Outcomes of the surviving sepsis campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis 2012; 12: 919–924.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Dellinger RP,
    2. Levy MM,
    3. Rhodes A,
    4. Annane D,
    5. Gerlach H,
    6. Opal SM, et al.
    Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41: 580–637.
    OpenUrlCrossRefPubMedWeb of Science
  7. 7.↵
    1. Landoni G,
    2. Baiardo Redaelli M,
    3. Sartini C,
    4. Zangrillo A,
    5. Bellomo R
    1. Nardelli P,
    2. Senarighi G,
    3. Votta CD.
    Goal-Directed Therapy. In: Landoni G, Baiardo Redaelli M, Sartini C, Zangrillo A, Bellomo R, editors. Reducing Mortality in Critically Ill Patients. Cham: Springer International Publishing; 2021. p. 99–106.
  8. 8.↵
    1. Levy MM,
    2. Evans LE,
    3. Rhodes A.
    The surviving sepsis campaign bundle: 2018 update. Intensive Care Med 2018; 44: 925–928.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Wang L,
    2. Ma X,
    3. He H,
    4. Su L,
    5. Guo Y,
    6. Shan G, et al.
    Compliance with the Surviving Sepsis Campaign Guideline 1-hour bundle for septic shock in China in 2018. Ann Transl Med 2021; 9: 278.
    OpenUrl
  10. 10.↵
    1. Filbin MR,
    2. Thorsen JE,
    3. Zachary TM,
    4. Lynch JC,
    5. Matsushima M,
    6. Belsky JB, et al.
    Antibiotic delays and feasibility of a 1-hour-from-triage antibiotic requirement: analysis of an emergency department sepsis quality improvement database. Ann Emerg Med 2020; 75: 93–99.
    OpenUrlPubMed
  11. 11.↵
    1. Seymour CW,
    2. Gesten F,
    3. Prescott HC,
    4. Friedrich ME,
    5. Iwashyna TJ,
    6. Phillips GS, et al.
    Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med 2017; 376: 2235–2244.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Peltan ID,
    2. Brown SM,
    3. Bledsoe JR,
    4. Sorensen J,
    5. Samore MH,
    6. Allen TL, et al.
    ED door-to-antibiotic time and long-term mortality in sepsis. Chest 2019; 155: 938–946.
    OpenUrl
  13. 13.↵
    1. Castaño P,
    2. Plaza M,
    3. Molina F,
    4. Hincapié C,
    5. Maya W,
    6. Cataño J, et al.
    Antimicrobial agent prescription: a prospective cohort study in patients with sepsis and septic shock. Trop Med Int Health 2019; 24: 175–184.
    OpenUrl
  14. 14.↵
    1. Abe T,
    2. Kushimoto S,
    3. Tokuda Y,
    4. Phillips GS,
    5. Rhodes A,
    6. Sugiyama T, et al.
    Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study. Critical Care 2019; 23: 1–11.
    OpenUrlCrossRef
  15. 15.↵
    1. Rothrock SG,
    2. Cassidy DD,
    3. Barneck M,
    4. Schinkel M,
    5. Guetschow B,
    6. Myburgh C, et al.
    Outcome of immediate versus early antibiotics in severe sepsis and septic shock: a systematic review and meta-analysis. Ann Emerg Med 2020; 76: 427–441.
    OpenUrlPubMed
  16. 16.↵
    1. Almutary A,
    2. Althunayyan S,
    3. Alenazi K,
    4. Alqahtani A,
    5. Alotaibi B,
    6. Ahmed M, et al.
    National Early Warning Score (NEWS) as prognostic triage tool for septic patients. Infect Drug Resist 2020; 13: 3843.
    OpenUrl
  17. 17.↵
    1. Shapiro SS,
    2. Wilk MB.
    An analysis of variance test for normality (complete samples). Biometrika 1965; 52: 591–611.
    OpenUrlCrossRefWeb of Science
  18. 18.↵
    1. Mann HB,
    2. Whitney DR.
    On a Test of whether one of two random variables is stochastically larger than the other. Ann Math Stat 1947; 18: 50–60.
    OpenUrl
  19. 19.↵
    1. Freund Y,
    2. Khoury A,
    3. Möckel M,
    4. Karamercan M,
    5. Dodt C,
    6. Leach R, et al.
    European Society of Emergency Medicine position paper on the 1-hour sepsis bundle of the Surviving Sepsis Campaign: expression of concern. Eur J Emerg Med 2019; 26: 232–233.
    OpenUrl
  20. 20.↵
    1. Campaign SS.
    SSC hour-1 bundle updated. Surviving sepsis campaign. [Update 2019; Accessed 2021 January 11]. Available from: https://www.sccm.org/SurvivingSepsisCampaign/Guidelines/Adult-Patients
  21. 21.↵
    IDSA Sepsis Task Force. Infectious Diseases Society of America (IDSA) POSITION STATEMENT: Why IDSA Did Not Endorse the Surviving Sepsis Campaign Guidelines. Clin Infect Dis 2018; 66: 1631–1635.
    OpenUrlCrossRef
  22. 22.↵
    1. Sterling SA,
    2. Miller WR,
    3. Pryor J,
    4. Puskarich MA,
    5. Jones AE.
    The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: a systematic review and meta-analysis. Crit Care Med 2015; 43: 1907.
    OpenUrlCrossRefPubMed
  23. 23.↵
    1. Jalili M,
    2. Barzegari H,
    3. Pourtabatabaei N,
    4. Honarmand AR,
    5. Boreiri M,
    6. Mehrvarz A, et al.
    Effect of door-to-antibiotic time on mortality of patients with sepsis in emergency department: a prospective cohort study. Acta Medica Iranica 2013; 51: 454–460.
    OpenUrl
  24. 24.↵
    1. Whiles BB,
    2. Deis AS,
    3. Simpson SQ.
    Increased time to initial antimicrobial administration is associated with progression to septic shock in severe sepsis patients. Crit Care Med 2017; 45: 623–629.
    OpenUrl
  25. 25.↵
    1. Sherwin R,
    2. Winters ME,
    3. Vilke GM,
    4. Wardi G.
    Does early and appropriate antibiotic administration improve mortality in emergency department patients with severe sepsis or septic shock? J Emerg Med 2017; 53: 588–595.
    OpenUrl
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