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Systematic ReviewSystematic Review
Open Access

The diagnostic accuracy of RT-PCR from self-collected saliva versus nasopharyngeal sampling

A systematic review and meta-analysis

Do Hyun Kim, Mohammed A. Basurrah, Jae Hong Han, Sung Won Kim and Se Hwan Hwang
Saudi Medical Journal January 2022, 43 (1) 9-30; DOI: https://doi.org/10.15537/smj.2022.43.1.20210743
Do Hyun Kim
From the Department of Otolaryngology-Head and Neck Surgery (DH. Kim, Han, SW. Kim), Seoul Saint Mary’s Hospital; from the Department of Otolaryngology-Head and Neck Surgery (Hwang), Bucheon Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, and from the Department of Surgery (Basurrah), College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia.
MD, PhD
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Mohammed A. Basurrah
From the Department of Otolaryngology-Head and Neck Surgery (DH. Kim, Han, SW. Kim), Seoul Saint Mary’s Hospital; from the Department of Otolaryngology-Head and Neck Surgery (Hwang), Bucheon Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, and from the Department of Surgery (Basurrah), College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia.
MD
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Jae Hong Han
From the Department of Otolaryngology-Head and Neck Surgery (DH. Kim, Han, SW. Kim), Seoul Saint Mary’s Hospital; from the Department of Otolaryngology-Head and Neck Surgery (Hwang), Bucheon Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, and from the Department of Surgery (Basurrah), College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia.
MD
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Sung Won Kim
From the Department of Otolaryngology-Head and Neck Surgery (DH. Kim, Han, SW. Kim), Seoul Saint Mary’s Hospital; from the Department of Otolaryngology-Head and Neck Surgery (Hwang), Bucheon Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, and from the Department of Surgery (Basurrah), College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia.
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Se Hwan Hwang
From the Department of Otolaryngology-Head and Neck Surgery (DH. Kim, Han, SW. Kim), Seoul Saint Mary’s Hospital; from the Department of Otolaryngology-Head and Neck Surgery (Hwang), Bucheon Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, and from the Department of Surgery (Basurrah), College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia.
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  • For correspondence: [email protected]
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Article Information

vol. 43 no. 1 9-30
DOI 
https://doi.org/10.15537/smj.2022.43.1.20210743
PubMed 
35022280

Published By 
Saudi Medical Journal
Online ISSN 
1658-3175
History 
  • Received September 21, 2021
  • Accepted December 7, 2021
  • Published online January 11, 2022.

Copyright & Usage 
Copyright: © Saudi Medical Journal This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

Author Information

  1. Do Hyun Kim, MD, PhD,
  2. Mohammed A. Basurrah, MD,
  3. Jae Hong Han, MD,
  4. Sung Won Kim, MD, PhD and
  5. Se Hwan Hwang, MD, PhD⇑
  1. From the Department of Otolaryngology-Head and Neck Surgery (DH. Kim, Han, SW. Kim), Seoul Saint Mary’s Hospital; from the Department of Otolaryngology-Head and Neck Surgery (Hwang), Bucheon Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, and from the Department of Surgery (Basurrah), College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia.
  1. Address correspondence and reprint request to: Dr. Se Hwan Hwang, Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. E-mail: yellobird{at}catholic.ac.kr ORCID ID: https://orcid.org/0000-0002-2838-7820
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Saudi Medical Journal: 43 (1)
Saudi Medical Journal
Vol. 43, Issue 1
1 Jan 2022
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The diagnostic accuracy of RT-PCR from self-collected saliva versus nasopharyngeal sampling
Do Hyun Kim, Mohammed A. Basurrah, Jae Hong Han, Sung Won Kim, Se Hwan Hwang
Saudi Medical Journal Jan 2022, 43 (1) 9-30; DOI: 10.15537/smj.2022.43.1.20210743

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The diagnostic accuracy of RT-PCR from self-collected saliva versus nasopharyngeal sampling
Do Hyun Kim, Mohammed A. Basurrah, Jae Hong Han, Sung Won Kim, Se Hwan Hwang
Saudi Medical Journal Jan 2022, 43 (1) 9-30; DOI: 10.15537/smj.2022.43.1.20210743
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  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Appendix 1 - Participants, interventions, comparisons, outcomes, timings, and study design (PICOTS)
    • Appendix 2 - Study characteristics
    • Appendix 3 - Methodological quality of all included studies
    • Appendix 4 - Forest plots of the sensitivity of the included studies
    • Appendix 5 - Forest plots of the specificity of the included studies
    • Appendix 6 - Forest plots of the negative predictive value of the included studies
    • Appendix 7 - Forest plots of the positive predictive value of the included studies
    • Appendix 8 - Forest plots of A) the sensitivity, B) the specificity, C) the negative predictive value, and D) the positive predictive value regarding the effect of geographic differences on self-collected saliva for COVID-19
    • Appendix 9 - Forest plots of A) the sensitivity, B) the specificity, C) the negative predictive value, and D) the positive predictive value regarding the effect of saliva collection method on self-collected saliva for COVID-19
    • Appendix 10 - Forest plots of A) the sensitivity, B) the specificity, C) the negative predictive value, and D) the positive predictive value regarding the effect of presence or absence of symptoms on the diagnostic odds ratios on self-collected saliva for COVID-19
    • Appendix 11 - The effect of geographic differences on the diagnostic odds ratios of self-collected saliva for COVID-19
    • Appendix 12 - The effect of saliva collection method on the diagnostic odds ratios of self-collected saliva for COVID-19
    • Appendix 13 - The effect of presence or absence of symptoms on the diagnostic odds ratios of self-collected saliva for COVID-19
    • Footnotes
    • References
  • Figures & Data
  • eLetters
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  • PDF

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Keywords

  • coronavirus infections
  • nasopharynx
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  • specimen handling

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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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