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Research ArticleOriginal Article
Open Access

The relationship between the visceral adiposity index and carotid atherosclerosis in different genders and age groups

Jing Cao, Shengpeng Liu, Hebin Xie, Yu Zhang and Yalin Zeng
Saudi Medical Journal February 2022, 43 (2) 169-176; DOI: https://doi.org/10.15537/smj.2022.43.2.20210824
Jing Cao
From the Department of Statistical Office (Cao), from the Science and Education Department (Xie), from the Rehabilitation Department (Zhang), from the Physical Examination Center (Zeng), The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha; and from the Pediatric Department (Liu), Shenzhen People’s Hospital, China.
MM, MS
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  • For correspondence: [email protected]
Shengpeng Liu
From the Department of Statistical Office (Cao), from the Science and Education Department (Xie), from the Rehabilitation Department (Zhang), from the Physical Examination Center (Zeng), The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha; and from the Pediatric Department (Liu), Shenzhen People’s Hospital, China.
MD, PhD
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Hebin Xie
From the Department of Statistical Office (Cao), from the Science and Education Department (Xie), from the Rehabilitation Department (Zhang), from the Physical Examination Center (Zeng), The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha; and from the Pediatric Department (Liu), Shenzhen People’s Hospital, China.
MM, MS
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Yu Zhang
From the Department of Statistical Office (Cao), from the Science and Education Department (Xie), from the Rehabilitation Department (Zhang), from the Physical Examination Center (Zeng), The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha; and from the Pediatric Department (Liu), Shenzhen People’s Hospital, China.
MM, MS
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Yalin Zeng
From the Department of Statistical Office (Cao), from the Science and Education Department (Xie), from the Rehabilitation Department (Zhang), from the Physical Examination Center (Zeng), The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha; and from the Pediatric Department (Liu), Shenzhen People’s Hospital, China.
MM, MS
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    Figure 1

    - Receiver operating characteristic of obesity indices (VAI, BMI, WC, HC) comparing the carotid atherosclerosis predictive values A) ROC curves in females 18-44 years of age, B) ROC curves in females >44 years of age, and C) ROC curves in all females. #The differences of AUC between VAI and the index were significant (p<0.001); ROC: receiver operating characteristic, BMI: body mass index, WC: waist circumference, HC: hip circumference

Tables

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    Table 1

    - Characteristics of patients stratified by visceral adiposity index tertiles.

    CharacteristicsFemale (n=1136)P-valueMale(n=863)P-value
    Tertile 1 (≤1.05)Tertile 2 (1.06 to 1.86)Tertile 3 (>1.86)Tertile 1 (≤1.26)Tertile 2 (1.27 to 2.17)Tertile 3(>2.17)
    No. of cases378382376 285287291 
    Age (years), x±s45.7±16.9748.45±16.3247.86±16.590.05744.42±16.9347.29±18.7845.57±17.660.153
    Body mass index (kg/m2), mean±SD22.86±3.6423.42±3.8224.66±4.34<0.00122.66±3.7423.78±4.0224.42±4.23<0.001
    Waist circumference (cm), mean±SD73.13±10.2275.13±10.2975.87±9.930.00175.17±10.8676.68±10.6778.78±10.59<0.001
    Hip circumference (cm), mean±SD89.14±8.6390.48±8.1890.69±7.890.02088.55±7.3488.67±8.3190.32±8.510.013
    Total cholesterol (mmol/L), mean±SD4.91±0.875.14±0.975.23±0.96<0.0014.98±0.915.13±0.955.2±0.990.016
    Triglyceride (mmol/L), M (P25,P75)0.80 (0.65,0.94)1.29 (1.08,1.51)2.25 (1.84,3.07)<0.0010.81 (0.64,0.95)1.30 (1.11,1.51)2.19 (1.77,2.76)<0.001
    High-density lipoprotein cholesterol (mmol/L), mean±SD1.59±0.331.28±0.241.06±0.18<0.0011.64±0.361.26±0.221.07±0.17<0.001
    Low-density lipoprotein cholesterol (mmol/L), mean±SD2.91±0.763.29±0.863.10±0.88<0.0012.9±0.783.29±0.873.14±0.93<0.001
    Fasting plasma glucos (mmol/L), mean±SD4.98 (4.71,5.36)5.09 (4.74,5.43)5.26 (4.94,5.80)<0.0014.99 (4.52,5.29)5.15 (4.57,5.48)5.24 (4.93,5.53)<0.001
    Family history of hypertension99 (26.1)116 (30.4)96 (25.5)0.26972 (25.3)60 (20.9)77 (26.5)0.262
    Family history of diabetes mellitus17 (4.5)20 (5.24)12 (3.19)0.37413 (4.56)9 (3.14)16 (5.5)0.379
    Hypertension168 (44.4)186 (48.7)189 (50.3)0.254131(46.0)138 (48.1)153 (52.6)0.268
    Diabetes mellitus41 (10.9)49 (12.8)66 (17.6)0.02329 (10.2)31 (10.8)56 (19.2)0.002
    Smoking5 (1.3)10 (2.6)19 (5.1)0.009140 (49.1)128 (44.6)134 (46.1)0.542
    Drinking9 (2.4)13 (3.4)18 (4.8)0.198114 (40.0)104 (36.2)118 (40.6)0.513
    Tea drinking ≥5 times / week118 (31.2)136 (35.6)136 (36.1)0.292145 (50.9)152 (53.0)167 (57.4)0.188
    Exercise ≥3 times / week105 (27.8)123 (32.2)102 (27.1)0.24670 (24.7)101 (35.2)84 (28.9)0.020
    High-salt diet99 (26.2)85 (22.3)101 (26.9)0.28580 (28.1)91 (31.7)83 (28.5)0.581
    Like pickled food39 (10.3)42 (11.0)34 (9.0)0.66519 (6.7)26 (9.1)23 (7.9)0.569
    Sweets ≥3 times / week64 (16.9)62 (16.2)54 (14.4)0.60751 (17.9)64 (22.3)56 (19.2)0.399
    Working hours over 10 hours /day10 (2.7)20 (5.2)19 (5.1)0.14723 (8.07)22 (7.7)37 (12.7)0.071
    • Values are presented as number and percentage (%), unless otherwise stated.

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    Table 2

    - Relationship between VAI and CAS in different genders.

    GenderModel oneModel two
    OR (95%CI)P-valueOR (95%CI)P-value
    Female
    Tertile 1Reference Reference 
    Tertile 21.99(1.48~2.67)<0.0012.16(1.51~3.08)<0.001
    Tertile 32.26(1.68~3.03)<0.0012.44(1.50~3.98)<0.001
    Male
    Tertile 1Reference Reference 
    Tertile 21.40(1.01~1.95)0.0441.47(0.97~2.23)0.071
    Tertile 31.44(1.04~2.00)0.0291.74(1.05~3.16)0.056
    • Model one was not adjusted. Model 2 was adjusted for body mass index, waist circumference, Hip circumference, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, diabetes mellitus, and current smoking. VAI: visceral adiposity index, CAS: carotid atherosclerosis, CI: confidence interval

    • View popup
    Table 3

    - Relationship between VAI and CAS in different ages.

    AgeFemaleMale
    Model oneModel twoModel oneModel two
    OR (95%CI)P-valueOR (95%CI)P-valueOR(95%CI)P-valueOR(95%CI)P-value
    18-44 years
    Tertile 1Reference Reference Reference Reference 
    Tertile 21.59(0.99~2.56)0.061.54(0.85~2.79)0.1561.41(0.86~2.29)0.1721.716(0.90~3.26)0.099
    Tertile 31.75(1.10~2.80)0.0191.52(0.67~3.44)0.3151.23(0.75~2.01)0.4072.44(0.832~4.64)0.124
    >44years
    Tertile 1Reference Reference Reference Reference 
    Tertile 22.17(1.50~3.19)<0.0012.42(1.53~3.82)<0.0011.40(0.88~2.20)0.1531.65(0.94~2.90)0.084
    Tertile 32.68(1.81~3.97)<0.0013.09(1.64~5.82)<0.0011.86(1.17~2.95)0.0092.00(0.95~4.42)0.069
    • Model one was not adjusted. Model 2 was adjusted for body mass index, waist circumference, hip circumference, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, diabetes mellitus, and current smoking. VAI: visceral adiposity index; CAS: carotid atherosclerosis; CI: cofidence interval

    • View popup
    Table 4

    - Area under the curve and 95%CI of VAI for identifying CAS by gender and age.

    Different populationsAUCStandarderrorsP-value95%CI for AUC
    Lower boundUpper bound
    All subject groups0.5610.013<0.0010.5350.586
    All females0.5950.017<0.0010.5620.628
    In female 18–44 years of age0.5750.0280.0080.520.629
    In female >44years of age0.6100.022<0.0010.5660.653
    All males0.5370.020.0600.4990.575
    In female 18–44 years of age0.5140.0290.6400.4570.57
    In female >44years of age0.5530.0270.0560.4990.606
    • AUC: area under the curve, VAI: visceral adiposity index, CAS: carotid atherosclerosis, CI: confidence interval

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The relationship between the visceral adiposity index and carotid atherosclerosis in different genders and age groups
Jing Cao, Shengpeng Liu, Hebin Xie, Yu Zhang, Yalin Zeng
Saudi Medical Journal Feb 2022, 43 (2) 169-176; DOI: 10.15537/smj.2022.43.2.20210824

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The relationship between the visceral adiposity index and carotid atherosclerosis in different genders and age groups
Jing Cao, Shengpeng Liu, Hebin Xie, Yu Zhang, Yalin Zeng
Saudi Medical Journal Feb 2022, 43 (2) 169-176; DOI: 10.15537/smj.2022.43.2.20210824
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Keywords

  • visceral adiposity index
  • carotid atherosclerosis
  • lipid metabolism disorder
  • visceral obesity

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