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Research ArticleOriginal Article
Open Access

The effect of low flow anesthesia with sevoflurane on oxidative status

A prospective, randomized study

Hülya Kaşıkara, Ayça T. Dumanlı Özcan, Cemile K. Biçer, Almila Şenat, Abdüssamet Yalçın, Cemile Altın, Şemsi Mustafa Aksoy and Abdülkadir But
Saudi Medical Journal March 2022, 43 (3) 227-235; DOI: https://doi.org/10.15537/smj.2022.43.3.20210876
Hülya Kaşıkara
From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
MD, PhD
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  • For correspondence: [email protected]
Ayça T. Dumanlı Özcan
From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
MD, PhD
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Cemile K. Biçer
From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
MD, PhD
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Almila Şenat
From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
MD, PhD
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Abdüssamet Yalçın
From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
MD, PhD
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Cemile Altın
From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
MD, PhD
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Şemsi Mustafa Aksoy
From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
MD, PhD
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Abdülkadir But
From the Department of Anesthesiology and Reanimation (Kaşıkara, Dumanlı Özcan), Ankara City Hospital, from the Department of Medical Biochemistry (Biçer), School of Medicine; from the Department of General Surgery (Yalçın); from the Department of Anesthesiology and Reanimation (Aksoy, But); Ankara Yıldırım Beyazıt University, and from the Department of Anesthesiology and Reanimation (Altın), Hacettepe University, Ankara, Turkey.
MD, PhD
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References

  1. 1.↵
    1. Tsuchiya M,
    2. Shiomoto K,
    3. Mizutani K,
    4. Fujioka K,
    5. Suehiro K,
    6. Yamada T, et al.
    Reduction of oxidative stress a key for enhanced postoperative recovery with fewer complications in esophageal surgery patients: randomized control trial to investigate therapeutic impact of anesthesia management and usefulness of simple blood test for prediction of high-risk patients. Medicine (Baltimore) 2018; 97: e12845.
    OpenUrl
  2. 2.↵
    1. Lucio LMC,
    2. Braz MG,
    3. do Nascimento Junior P,
    4. Braz JRC,
    5. Braz LG
    . [Occupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gases]. Braz J Anesthesiol 2018; 68: 33–41. [in Portuguese]
    OpenUrl
  3. 3.
    1. Stevens JL,
    2. Feelisch M,
    3. Martin DS.
    Perioperative oxidative stress: the unseen enemy. Anesth Analg 2019; 129: 1749–1760.
    OpenUrl
  4. 4.↵
    1. Yılmaz Doğru H,
    2. Benli İ,
    3. Doğru S.
    The oxidative/anti-oxidative effects of sevoflurane on reproductive system of females: an experimental study. Turk J Obstet Gynecol 2017; 14: 228–232.
    OpenUrl
  5. 5.↵
    1. Kundović SA,
    2. Rašić D,
    3. Popović L,
    4. Peraica M,
    5. Črnjar K.
    Oxidative stress under general intravenous and inhalation anaesthesia. Arh Hig Rada Toksikol 2020; 71: 169–177.
    OpenUrl
  6. 6.↵
    1. Turell L,
    2. Radi R,
    3. Alvarez B.
    The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med 2013; 65: 244–253.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Köseoğlu H,
    2. Alışık M,
    3. Başaran M,
    4. Tayfur Yürekli Ö,
    5. Solakoğlu T,
    6. Tahtacı M, et al.
    Dynamic thiol/disulphide homeostasis in acute pancreatitis. Turk J Gastroenterol 2018; 29: 348–353.
    OpenUrl
  8. 8.↵
    1. Varughese S,
    2. Ahmed R.
    Environmental and occupational considerations of anesthesia: a narrative review and update. Anesth Analg 2021; 133: 826–835.
    OpenUrl
  9. 9.↵
    1. Ozcan ATD,
    2. Doger C,
    3. Ozturk L,
    4. Yungul A,
    5. Kurtsahin M,
    6. Neselioglu S, et al.
    Comparison of the effects of sevoflurane and desflurane on thiol-disulfide homeostasis in patients undergoing laparoscopic cholecystectomy. Eurasian J Med 2019; 51: 70–74.
    OpenUrl
  10. 10.↵
    1. Karabayirli S,
    2. Surgit O,
    3. Kasikara H,
    4. Koca Bicer C,
    5. Ergin M,
    6. Irem Demircioglu R, et al.
    The effects of adding ischemic preconditioning during desflurane inhalation anesthesia or propofol total intravenous anesthesia on pneumoperitoneum-induced oxidative stress. Acta Chir Belg 2017; 117: 36–44.
    OpenUrlPubMed
  11. 11.↵
    1. Erel O,
    2. Neselioglu S.
    A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014; 47: 326–332.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Amodeo G,
    2. Bugada D,
    3. Franchi S,
    4. Moschetti G,
    5. Grimaldi S,
    6. Panerai A, et al.
    Immune function after major surgical interventions: the effect of postoperative pain treatment. J Pain Res 2018; 11: 1297–1305.
    OpenUrlPubMed
  13. 13.↵
    1. Toro-Pérez J,
    2. Rodrigo R.
    Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome. Redox Rep 2021; 26: 35–44.
    OpenUrl
  14. 14.↵
    1. Singer M,
    2. Young PJ,
    3. Laffey JG,
    4. Asfar P,
    5. Taccone FS,
    6. Skrifvars MB, et al.
    Dangers of hyperoxia. Crit Care 2021; 25: 440.
    OpenUrl
  15. 15.↵
    1. Cronin WA,
    2. Forbes AS,
    3. Wagner KL,
    4. Kaplan P,
    5. Cataneo R,
    6. Phillips M, et al.
    Exhaled volatile organic compounds precedes pulmonary injury in a swine pulmonary oxygen toxicity model. Front Physiol 2019; 10: 1297.
    OpenUrl
  16. 16.↵
    1. Tollinche L,
    2. Tan K,
    3. Han A,
    4. Ojea L,
    5. Yeoh C.
    Analyzing volatile anesthetic consumption by auditing fresh gas flow: an observational study at an academic hospital. Int J Anesth Anesth 2018; 5: 064.
    OpenUrl
  17. 17.↵
    1. Glenski TA,
    2. Levine L.
    The implementation of low-flow anesthesia at a tertiary pediatric center: a quality improvement initiative. Paediatr Anaesth 2020; 30: 1139–1145.
    OpenUrl
  18. 18.↵
    1. Forman HJ,
    2. Zhang H.
    Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov 2021; 20: 689–709.
    OpenUrlCrossRef
  19. 19.↵
    1. Baba SP,
    2. Bhatnagar A.
    Role of thiols in oxidative stress. Curr Opin Toxicol 2018; 7: 133–139.
    OpenUrl
  20. 20.↵
    1. Ulrich K,
    2. Jakob U.
    The role of thiols in antioxidant systems. Free Radic Biol Med 2019; 140: 14–27.
    OpenUrlCrossRef
  21. 21.↵
    1. Cruz FF,
    2. Rocco PR,
    3. Pelosi P.
    Anti-inflammatory properties of anesthetic agents. Crit Care 2017; 21: 67.
    OpenUrl
  22. 22.↵
    1. Bingöl Tanrıverdi T,
    2. Tercan M,
    3. Güsun Halitoğlu A,
    4. Kaya A,
    5. Patmano G.
    Comparison of the effects of low-flow and normal-flow desflurane anaesthesia on inflammatory parameters in patients undergoing laparoscopic cholecystectomy. Turk J Anaesthesiol Reanim 2021; 49: 18–24.
    OpenUrl
  23. 23.↵
    1. Yuan JL,
    2. Kang K,
    3. Li B,
    4. Lu J,
    5. Miao MR,
    6. Kang X, et al.
    The effects of sevoflurane vs. propofol for inflammatory responses in patients undergoing lung resection: a meta-analysis of randomized controlled trials. Front Surg 2021; 8: 692734.
    OpenUrl
  24. 24.↵
    1. Zhou T,
    2. Guo S,
    3. Wang S,
    4. Li Q,
    5. Zhang M.
    Protective effect of sevoflurane on myocardial ischemia-reperfusion injury in rat hearts and its impact on HIF-1α and caspase-3 expression. Exp Ther Med 2017; 14: 4307–4311.
    OpenUrl
  25. 25.↵
    1. Liu D,
    2. Jin X,
    3. Zhang C,
    4. Shang Y.
    Sevoflurane relieves hepatic ischemia-reperfusion injury by inhibiting the expression of Grp78. Biosci Rep 2018; 38: BSR20180549.
    OpenUrlAbstract/FREE Full Text
  26. 26.↵
    1. Wang CM,
    2. Chen WC,
    3. Zhang Y,
    4. Lin S,
    5. He HF.
    Update on the mechanism and treatment of sevoflurane-induced postoperative cognitive dysfunction. Front Aging Neurosci 2021; 13: 702231.
    OpenUrl
  27. 27.↵
    1. Huang H,
    2. Hu C,
    3. Xu L,
    4. Zhu X,
    5. Zhao L,
    6. Min J.
    The effects of hesperidin on neuronal apoptosis and cognitive impairment in the sevoflurane anesthetized rat are mediated through the PI3/Akt/PTEN and Nuclear Factor-κB (NF-κB) signaling pathways. Med Sci Monit 2020; 26: e920522.
    OpenUrl
  28. 28.↵
    1. Jafarzadeh A,
    2. Hadavi M,
    3. Hassanshahi G,
    4. Rezaeian M,
    5. Vazirinejad R.
    General anesthetics on immune system cytokines: a narrative review article. Anesth Pain Med 2020; 10: e103033.
    OpenUrl
  29. 29.↵
    1. Campdesuner V,
    2. Teklie Y,
    3. Alkayali T,
    4. Pierce D,
    5. George J.
    Nitrous oxide-induced vitamin B12 deficiency resulting in myelopathy. Cureus 2020; 12: e9088.
    OpenUrl
  30. 30.↵
    1. Ayanoğlu Taş B,
    2. Şanlı Karip C,
    3. Abitağaoğlu S,
    4. Öztürk MC,
    5. Erdoğan Arı D.
    Comparison of minimal-flow sevoflurane versus desflurane anesthesia: randomized clinical trial. Braz J Anesthesiol 2022; 72: 77–82.
    OpenUrl
  31. 31.↵
    1. Bonanata J,
    2. Turell L,
    3. Antmann L,
    4. Ferrer-Sueta G,
    5. Botasini S,
    6. Méndez E, et al.
    The thiol of human serum albumin: acidity, microenvironment and mechanistic insights on its oxidation to sulfenic acid. Free Radic Biol Med 2017; 108: 952–962.
    OpenUrlCrossRefPubMed
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The effect of low flow anesthesia with sevoflurane on oxidative status
Hülya Kaşıkara, Ayça T. Dumanlı Özcan, Cemile K. Biçer, Almila Şenat, Abdüssamet Yalçın, Cemile Altın, Şemsi Mustafa Aksoy, Abdülkadir But
Saudi Medical Journal Mar 2022, 43 (3) 227-235; DOI: 10.15537/smj.2022.43.3.20210876

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The effect of low flow anesthesia with sevoflurane on oxidative status
Hülya Kaşıkara, Ayça T. Dumanlı Özcan, Cemile K. Biçer, Almila Şenat, Abdüssamet Yalçın, Cemile Altın, Şemsi Mustafa Aksoy, Abdülkadir But
Saudi Medical Journal Mar 2022, 43 (3) 227-235; DOI: 10.15537/smj.2022.43.3.20210876
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Keywords

  • low-flow anesthesia
  • Sevoflurane
  • thiol/disulfide homeostasis
  • oxidative status

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