Research ArticleOriginal Article
Open Access

Efficacy of resveratrol against breast cancer and hepatocellular carcinoma cell lines

Nouf A. ALkharashi
Saudi Medical Journal March 2023, 44 (3) 246-252; DOI: https://doi.org/10.15537/smj.2023.44.3.20220768

References

  1. 1.↵
    1. Sung H,
    2. Ferlay J,
    3. Siegel RL,
    4. Laversanne M,
    5. Soerjomataram I,
    6. Jemal A, et al.
    Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71: 209–249.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Qiao J,
    2. Liu Z,
    3. Fu YX.
    Adapting conventional cancer treatment for immunotherapy. J Mol Med (Berl) 2016; 94: 489–495.
    OpenUrl
  3. 3.↵
    1. Senapati S,
    2. Mahanta AK,
    3. Kumar S,
    4. Maiti P.
    Controlled drug delivery vehicles for cancer treatment and their performance. Signal Transduct Target Ther 2018; 3: 7.
    OpenUrl
  4. 4.↵
    1. Shah JP,
    2. Gil Z.
    Current concepts in management of oral cancer--surgery. Oral Oncol 2009; 45: 394–401.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Amjad MT,
    2. Chidharla A,
    3. Kasi A.
    Cancer chemotherapy. [Updated 2022; accessed 2022 Mar 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK564367/
  6. 6.↵
    1. Vuorelaa P,
    2. Leinonenb M,
    3. Saikkuc P,
    4. Tammelaa P,
    5. Rauhad JP,
    6. Wennberge T, et al.
    Natural products in the process of finding new drug candidates. Curr Med Chem 2004; 11: 1375–1389.
    OpenUrlCrossRefPubMedWeb of Science
  7. 7.↵
    1. Aggarwal BB,
    2. Bhardwaj A,
    3. Aggarwal RS,
    4. Seeram NP,
    5. Shishodia S,
    6. Takada Y.
    Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 2004; 24: 2783–2840.
    OpenUrlAbstract/FREE Full Text
  8. 8.↵
    1. Lang F,
    2. Qin Z,
    3. Li F,
    4. Zhang H,
    5. Fang Z,
    6. Hao E.
    Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells. PLoS One 2015; 10: e0129196.
    OpenUrl
  9. 9.↵
    1. Revel A,
    2. Raanani H,
    3. Younglai E,
    4. Xu J,
    5. Rogers I,
    6. Han R, et al.
    Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene. Journal of Applied Toxicology 2003; 23: 255–261.
    OpenUrlCrossRefPubMedWeb of Science
  10. 10.
    1. Stewart JR,
    2. Artime MC,
    3. O’Brian CA.
    Resveratrol: a candidate nutritional substance for prostate cancer prevention. J Nutr 2003; 133: 2440S–2443S.
    OpenUrlAbstract/FREE Full Text
  11. 11.
    1. Le Corre L,
    2. Chalabi N,
    3. Delort L,
    4. Bignon YJ,
    5. Bernard-Gallon DJ.
    Resveratrol and breast cancer chemoprevention: molecular mechanisms. Mol Nutr Food Res 2005; 49: 462–471.
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.
    1. Fukui M,
    2. Yamabe N,
    3. Zhu BT.
    Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo. Eur J Cancer 2010; 46: 1882–1891.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Liao PC,
    2. Ng LT,
    3. Lin LT,
    4. Richardson CD,
    5. Wang GH,
    6. Lin CC.
    Resveratrol arrests cell cycle and induces apoptosis in human hepatocellular carcinoma Huh-7 cells. J Med Food 2010; 13: 1415–1423.
    OpenUrlCrossRefPubMed
  14. 14.
    1. Liang YC,
    2. Tsai SH,
    3. Chen L,
    4. Lin-Shiau SY,
    5. Lin JK.
    Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. Biochem Pharmacol 2003; 65: 1053–1060.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Ko JH,
    2. Sethi G,
    3. Um JY,
    4. Shanmugam MK,
    5. Arfuso F,
    6. Kumar AP, et al.
    The role of resveratrol in cancer therapy. Int J Mol Sci 2017; 18: 2589.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Mahyar-Roemer M,
    2. Katsen A,
    3. Mestres P,
    4. Roemer K.
    Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse. Int J Cancer 2001; 94: 615–622.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Kuo PL,
    2. Chiang LC,
    3. Lin CC.
    Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells. Life Sci 2002; 72: 23–34.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Rafieian-Kopaei M,
    2. Shahinfard N,
    3. Rouhi-Boroujeni H,
    4. Gharipour M,
    5. Darvishzadeh-Boroujeni P.
    Effects of Ferulago angulata extract on serum lipids and lipid peroxidation. Evid Based Complement Alternat Med 2014; 2014: 680856.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Schmittgen TD,
    2. Livak KJ.
    Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008; 3: 1101–1108.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.↵
    1. Alotaibi MR,
    2. Hassan ZK,
    3. Al-Rejaie SS,
    4. Alshammari MA,
    5. Almutairi MM,
    6. Alhoshani AR, et al.
    Characterization of apoptosis in a breast cancer cell line after IL-10 silencing. Asian Pac J Cancer Prev 2018; 19: 777–783.
    OpenUrl
  21. 21.
    1. Honarpisheh M,
    2. Desai J,
    3. Marschner JA,
    4. Weidenbusch M,
    5. Lech M,
    6. Vielhauer V, et al.
    Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis. Biosci Rep 2016; 36: e00425.
    OpenUrlAbstract/FREE Full Text
  22. 22.
    1. Buskaran K,
    2. Bullo S,
    3. Hussein MZ,
    4. Masarudin MJ,
    5. Mohd Moklas MA,
    6. Fakurazi S.
    Anticancer molecular mechanism of protocatechuic acid loaded on folate coated functionalized graphene oxide nanocomposite delivery system in human hepatocellular carcinoma. Materials (Basel) 2021; 14: 817.
    OpenUrl
  23. 23.↵
    1. Jiang Q,
    2. Yang M,
    3. Qu Z,
    4. Zhou J,
    5. Zhang Q.
    Resveratrol enhances anticancer effects of paclitaxel in HepG2 human liver cancer cells. BMC Complement Altern Med 2017; 17: 477.
    OpenUrl
  24. 24.↵
    1. Desai AG,
    2. Qazi GN,
    3. Ganju RK,
    4. El-Tamer M,
    5. Singh J,
    6. Saxena AK, et al.
    Medicinal plants and cancer chemoprevention. Curr Drug Metab 2008; 9: 581–591.
    OpenUrlPubMed
  25. 25.↵
    1. Kennedy DO,
    2. Wightman EL,
    3. Reay JL,
    4. Lietz G,
    5. Okello EJ,
    6. Wilde A, et al.
    Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010; 91: 1590–1597.
    OpenUrlAbstract/FREE Full Text
  26. 26.
    1. Wightman EL,
    2. Reay JL,
    3. Haskell CF,
    4. Williamson G,
    5. Dew TP,
    6. Kennedy DO.
    Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr 2014; 112: 203–213.
    OpenUrlPubMed
  27. 27.↵
    1. Zhang LX,
    2. Li CX,
    3. Kakar MU,
    4. Khan MS,
    5. Wu PF,
    6. Amir RM, et al.
    Resveratrol (RV): a pharmacological review and call for further research. Biomed Pharmacother 2021; 143: 112164.
    OpenUrl
  28. 28.↵
    1. Riss TL,
    2. Moravec RA,
    3. Niles AL, et al.
    Cell viability assays. [Updated 2016; accessed 2022 July 1]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK144065/
  29. 29.↵
    1. Takashina M,
    2. Inoue S,
    3. Tomihara K,
    4. Tomita K,
    5. Hattori K,
    6. Zhao QL, et al.
    Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells. Int J Oncol 2017; 50: 787–797.
    OpenUrl
  30. 30.↵
    1. de Freitas Silva M,
    2. Coelho LF,
    3. Guirelli IM,
    4. Pereira RM,
    5. Ferreira-Silva GÁ,
    6. Graravelli GY, et al.
    Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells. Toxicol In Vitro 2018; 50: 75–85.
    OpenUrl
  31. 31.↵
    1. Al-Abd AM,
    2. Mahmoud AM,
    3. El-Sherbiny GA,
    4. El-Moselhy MA,
    5. Nofal SM,
    6. El-Latif HA, et al.
    Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro. Cell Prolif 2011; 44: 591–601.
    OpenUrlCrossRefPubMed
  32. 32.↵
    1. Lu R,
    2. Serrero G. Resveratrol
    , a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol 1999; 179: 297–304.
    OpenUrlCrossRefPubMedWeb of Science
  33. 33.↵
    1. Stervbo U,
    2. Vang O,
    3. Bonnesen C.
    Time- and concentration-dependent effects of resveratrol in HL-60 and HepG2 cells. Cell Prolif 2006; 39: 479–493.
    OpenUrlCrossRefPubMedWeb of Science
  34. 34.↵
    1. Geng Wf, Wu Cl,
    2. Chen Yq, et al.
    Research about the joint effect of taxol and resveratrol on human liver cancer HepG-2. J CWNU (Natural Sciences) 2012; 03.
  35. 35.↵
    1. Xiong Y,
    2. Wang L,
    3. Li Y,
    4. Chen M,
    5. He W,
    6. Qi L.
    The long non-coding RNA XIST interacted with MiR-124 to modulate bladder cancer growth, invasion and migration by targeting androgen receptor (AR). Cell Physiol Biochem 2017; 43: 405–418.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Wong RS.
    Apoptosis in cancer: from pathogenesis to treatment. J Exp Clin Cancer Res 2011; 30: 87.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. Elmore S.
    Apoptosis: a review of programmed cell death. Toxicol Pathol 2007; 35: 495–516.
    OpenUrlCrossRefPubMed
  38. 38.↵
    1. Yaacoub K,
    2. Pedeux R,
    3. Tarte K,
    4. Guillaudeux T.
    Role of the tumor microenvironment in regulating apoptosis and cancer progression. Cancer Lett 2016; 378: 150–159.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. Khosravi-Far R,
    2. Esposti MD.
    Death receptor signals to mitochondria. Cancer Biol Ther 2004; 3: 1051–1057.
    OpenUrlCrossRefPubMedWeb of Science
  40. 40.↵
    1. Chen G,
    2. Cheng X,
    3. Zhao M,
    4. Lin S,
    5. Lu J,
    6. Kang J, et al.
    RIP1-dependent Bid cleavage mediates TNFa-induced but Caspase-3-independent cell death in L929 fibroblastoma cells. Apoptosis 2015; 20: 92–109.
    OpenUrlCrossRefPubMed
  41. 41.↵
    1. Li P,
    2. Zhou L,
    3. Zhao T,
    4. Liu X,
    5. Zhang P,
    6. Liu Y, et al.
    Caspase-9: structure, mechanisms and clinical application. Oncotarget 2017; 8: 23996–24008.
    OpenUrlCrossRef
  42. 42.↵
    1. Agostini-Dreyer A,
    2. Jetzt AE,
    3. Stires H,
    4. Cohick WS.
    Endogenous IGFBP-3 mediates intrinsic apoptosis through modulation of Nur77 phosphorylation and nuclear export. Endocrinology 2015; 156: 4141–4151.
    OpenUrl
  43. 43.↵
    1. Su JL,
    2. Yang CY,
    3. Zhao M,
    4. Kuo ML,
    5. Yen ML.
    Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol. J Biol Chem 2007; 282: 19385–19398.
    OpenUrlAbstract/FREE Full Text
  44. 44.↵
    1. Harper CE,
    2. Patel BB,
    3. Wang J,
    4. Arabshahi A,
    5. Eltoum IA,
    6. Lamartiniere CA.
    Resveratrol suppresses prostate cancer progression in transgenic mice. Carcinogenesis 2007; 28: 1946–1953.
    OpenUrlCrossRefPubMedWeb of Science
  45. 45.↵
    1. Banerjee S,
    2. Bueso-Ramos C,
    3. Aggarwal BB.
    Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 2002; 62: 4945–4954.
    OpenUrlAbstract/FREE Full Text
  46. 46.
    1. Baur JA,
    2. Sinclair DA.
    Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5: 493–506.
    OpenUrlCrossRefPubMedWeb of Science
  47. 47.
    1. Bhat KPL,
    2. Kosmeder JW 2nd.,
    3. Pezzuto JM.
    Biological effects of resveratrol. Antioxid Redox Signal 2001; 3: 1041–1064.
    OpenUrlCrossRefPubMedWeb of Science
  48. 48.↵
    1. Dörrie J,
    2. Gerauer H,
    3. Wachter Y,
    4. Zunino SJ.
    Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 2001; 61: 4731–4739.
    OpenUrlAbstract/FREE Full Text
  49. 49.↵
    1. Kuchta K,
    2. Towpik J,
    3. Biernacka A,
    4. Kutner J,
    5. Kudlicki A,
    6. Ginalski K, et al.
    Predicting proteome dynamics using gene expression data. Sci Rep 2018; 8: 13866.
    OpenUrl
Back to top

In this issue

Print
Download PDF
Email Article
Citation Tools
Bookmark this article

Jump to section

Keywords