Research ArticleOriginal Article
Open Access

Clinical and pathological characteristics of extra-cranial germ cell tumors

A 30-year single-center experience in Saudi Arabia

Dania A. Monagel, Aletani Tala, Alghamdi Arwa, Banjar Sereen, Hakeem Ilana, Hannef Deena, Ahmed Omaima and Elimam Naglla
Saudi Medical Journal May 2023, 44 (5) 498-499; DOI: https://doi.org/10.15537/smj.2023.44.5.20230070

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  • Table 1

    - Tumor stage in relation to tumor site and tumor markers (AFP, Beta- HCG).

    Stagen (%)SiteAFPBeta-HCG
    Stage 118 (37.5)◾ Testes: 13 patients
    ◾ Ovaries: 4 patients
    ◾ Sacro-coccyx: 1 patient    		Normal 5 patients
    High: 13 patients    		Normal: 13 patients
    High: 1 patient
    Missing: 4 patients
    Stage 26 (12.5%)◾ Testes: 1 patient
    ◾ Ovaries: 2 patients
    ◾ Sacro-coccyx: 1 patient
    ◾ Retroperitoneum: 1 patient
    ◾ Abdomen: 1 patient    		Normal: 2 patients
    High: 4 patients    		Normal: 6 patients
    Stage 310 (20.8)◾ Ovaries: 7 patients
    ◾ Sacro-coccyx: 1 patient
    ◾ Retroperitoneum: 1 patient
    ◾ Mediastinum: 1 patient    		Normal: 3 patients
    High: 7 patients    		Normal: 7 patients
    High: 2 patients
    Missing: 1 patient
    Stage 414 (29.1%)◾ Testes: 2 patients
    ◾ Ovaries: 4 patients
    ◾ Sacro-coccyx: 4 patients
    ◾ Abdomen: 2 patients
    ◾ Mediastinum: 1 patient
    ◾ Intra-orbital: 1 patient    		Normal: 3 patients
    High: 9 patients
    Missing: 4 patients    		Normal: 8 patients
    High: 3 patients
    Missing: 3 patient

    AFP: α-1-fetoprotein, HCG: human chorionic gonadotropin

    • Table 2

      - Treatment in relation to stage.

      StageNumber of patientsNo chemotherapyChemotherapy
      Stage 11816 (88.9% of stage 1)2 (11.1% of stage 1)
      Stage 265 (83.3% of stage 2)1 (16.7% of stage 2)
      Stage 3103 (30.0% of stage 3)7 (70.0% of stage 3)
      Stage 4141 (7.1% of stage 4)13 (92.9% of stage 4)
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