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Research ArticleOriginal Article
Open Access

Ras-related associated with diabetes genes for biomarker-based therapeutics in cancer

A comparative evolutionary genomic study

Mohammed A. Hakami
Saudi Medical Journal February 2024, 45 (2) 111-120; DOI: https://doi.org/10.15537/smj.2024.45.2.20230564
Mohammed A. Hakami
From the Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Al-Quwayiyah, Riyadh, Kingdom of Saudi Arabia.
PhD
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References

  1. 1.↵
    1. Guyton KZ,
    2. Kensler TW
    . Prevention of liver cancer. Curr Oncol Rep 2002; 4: 464-470.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Zender L,
    2. Villanueva A,
    3. Tovar V,
    4. Sia D,
    5. Chiang DY,
    6. Llovet JM
    . Cancer gene discovery in hepatocellular carcinoma. J Hepatol 2010; 52: 921-929.
    OpenUrlCrossRefPubMedWeb of Science
  3. 3.↵
    1. Ahmad S,
    2. Singh V,
    3. Gautam HK,
    4. Raza K
    . Multisampling-based docking reveals Imidazolidinyl urea as a multitargeted inhibitor for lung cancer: an optimisation followed multi-simulation and in-vitro study. J Biomol Struct Dyn 2023: 1-18.
  4. 4.↵
    1. Wang Y,
    2. Li G,
    3. Mao F,
    4. Li X,
    5. Liu Q,
    6. Chen L, et al.
    Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model. J Biol Chem 2014; 289: 14225-14238.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Reynet C,
    2. Kahn CR
    . Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science 1993; 262: 1441-1444.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. Shang R,
    2. Wang J,
    3. Sun W,
    4. Dai B,
    5. Ruan B,
    6. Zhang Z, et al.
    RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma. Tumour Biol 2016; 37: 5097-5105.
    OpenUrl
  7. 7.↵
    1. Blandino G,
    2. Valenti F,
    3. Sacconi A,
    4. Di Agostino S
    . Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease. Semin Cell Dev Biol 2020; 98: 105-117.
    OpenUrlCrossRef
  8. 8.
    1. Wei Z,
    2. Guo H,
    3. Qin J,
    4. Lu S,
    5. Liu Q,
    6. Zhang X, et al.
    Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence. Free Radic Biol Med 2019; 130: 267-277.
    OpenUrl
  9. 9.↵
    1. Liu J,
    2. Zhang C,
    3. Wu R,
    4. Lin M,
    5. Liang Y,
    6. Liu J, et al.
    RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling. Oncotarget 2015; 6: 14982-14992.
    OpenUrl
  10. 10.↵
    1. Buganim Y,
    2. Solomon H,
    3. Rais Y,
    4. Kistner D,
    5. Nachmany I,
    6. Brait M, et al.
    p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways. Cancer Res 2010; 70: 2274-2284.
    OpenUrlAbstract/FREE Full Text
  11. 11.↵
    1. Ahmad S,
    2. Raza K
    . Identification of 5-nitroindazole as a multitargeted inhibitor for CDK and transferase kinase in lung cancer: a multisampling algorithm-based structural study. Mol Divers 2023.
  12. 12.↵
    1. Montezano AC,
    2. Dulak-Lis M,
    3. Tsiropoulou S,
    4. Harvey A,
    5. Briones AM,
    6. Touyz RM
    . Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies. Can J Cardiol 2015; 31: 631-641.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Ahmad S,
    2. Bhanu P,
    3. Kumar J,
    4. Pathak RK,
    5. Mallick D,
    6. Uttarkar A, et al.
    Molecular dynamics simulation and docking analysis of NF-κB protein binding with sulindac acid. Bioinformation 2022; 18: 170-179.
    OpenUrl
  14. 14.
    1. Ahmad S,
    2. Dahiya V,
    3. Vibhuti A,
    4. Pandey RP,
    5. Tripathi MK,
    6. Yadav MK
    . Therapeutic protein-based vaccines. [Updated 2023; 2023 Apr 20]. Available from: https://link.springer.com/chapter/10.1007/978-981-19-8249-1_13
  15. 15.
    1. Ahmad S,
    2. Kaul T,
    3. Chitkara P,
    4. Raza K
    . Comparative insight into rice chloroplasts genome: mutational phylogenomics reveals Echinochloa oryzicola as the ongoing progenitor of rice. Genet Resour Crop Evol 2022; 70: 869-885.
    OpenUrl
  16. 16.↵
    1. Ahmad S,
    2. Khan FN,
    3. Ramlal A,
    4. Begum S,
    5. Qazi S,
    6. Raza K
    . Nanoinformatics and nanomodeling: recent developments in computational nanodrug design and delivery systems. [Updated 2023; 2023 Apr 20]. Available from: https://www.sciencedirect.com/science/article/abs/pii/B9780323911825000012?via%3Dihub
  17. 17.↵
    1. Maegley KA,
    2. Admiraal SJ,
    3. Herschlag D
    . Ras-catalyzed hydrolysis of GTP: a new perspective from model studies. Proc Natl Acad Sci U S A 1996; 93: 8160-8166.
    OpenUrlAbstract/FREE Full Text
  18. 18.
    1. Matte A,
    2. Tari LW,
    3. Delbaere LT
    . How do kinases transfer phosphoryl groups? Structure 1998; 6: 413-419.
    OpenUrlCrossRefPubMed
  19. 19.
    1. Colicelli J
    . Human RAS superfamily proteins and related GTPases. Sci STKE 2004; 2004: RE13.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Kaput J,
    2. Noble J,
    3. Hatipoglu B,
    4. Kohrs K,
    5. Dawson K,
    6. Bartholomew A
    . Application of nutrigenomic concepts to type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis 2007; 17: 89-103.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Weis A
    . Investigating the potential of circulating microRNAs as non-invasive biomarkers in cirrhosis and hepatocellular carcinoma. [Updated 2019; 2023 Apr 20]. Available from: https://doi.org/10.14264/uql.2019.600
  22. 22.↵
    1. Reynet C,
    2. Kahn CR
    . Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle. Proc Natl Acad Sci U S A 2001; 98: 3422-3427.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Antonetti DA,
    2. Reynet C,
    3. Kahn CR
    . Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus. J Clin Invest 1995; 95: 1383-1388.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.↵
    1. Sun Z,
    2. Li Y,
    3. Tan X,
    4. Liu W,
    5. He X,
    6. Pan D, et al.
    Friend or foe: regulation, downstream effectors of RRAD in cancer. Biomolecules 2023; 13: 477.
    OpenUrl
  25. 25.↵
    1. Kim HK,
    2. Lee I,
    3. Kim ST,
    4. Lee J,
    5. Kim KM,
    6. Park JO, et al.
    RRAD expression in gastric and colorectal cancer with peritoneal carcinomatosis. Sci Rep 2019; 9: 19439.
    OpenUrlCrossRef
  26. 26.↵
    1. Hoff KJ,
    2. Stanke M
    . Predicting genes in single genomes with AUGUSTUS. Curr Protoc Bioinformatics 2019; 65: e57.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Kearse M,
    2. Moir R,
    3. Wilson A,
    4. Stones-Havas S,
    5. Cheung M,
    6. Sturrock S, et al.
    Geneious basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data. Bioinformatics 2012; 28: 1647-1649.
    OpenUrlCrossRefPubMedWeb of Science
  28. 28.↵
    1. Rice P,
    2. Longden I,
    3. Bleasby A
    . EMBOSS: the European molecular biology open software suite. Trends Genet 2000; 16: 276-277.
    OpenUrlCrossRefPubMedWeb of Science
  29. 29.↵
    1. Olsen C,
    2. Qaadri K,
    3. Moir R,
    4. Kearse M,
    5. Buxton S,
    6. Cheung M
    . Geneious R7: a bioinformatics platform for biologists. [Updated 2014; December 2022]. Available from: https://www.geneious.com/
  30. 30.↵
    1. Madeira F,
    2. Park YM,
    3. Lee J,
    4. Buso N,
    5. Gur T,
    6. Madhusoodanan N, et al.
    The EMBL-EBI search and sequence analysis tools APIs in 2019. Nucleic Acids Res 2019; 47: W636-W641.
    OpenUrlCrossRefPubMed
  31. 31.↵
    1. Letunic I,
    2. Bork P
    . Interactive tree of life (iTOL): an online tool for phylogenetic tree display and annotation. Bioinformatics 2007; 23: 127-128.
    OpenUrlCrossRefPubMedWeb of Science
  32. 32.↵
    1. Allendorf FW,
    2. Hohenlohe PA,
    3. Luikart G
    . Genomics and the future of conservation genetics. Nat Rev Genet 2010; 11: 697-709.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. Ahmad S,
    2. Chitkara P,
    3. Khan FN,
    4. Kishan A,
    5. Alok V,
    6. Ramlal A, et al.
    Mobile technology solution for COVID-19: surveillance and prevention. SCI 2020; 923: 79-108.
    OpenUrl
  34. 34.↵
    1. Ahmad S,
    2. Bano N,
    3. Qazi S,
    4. Yadav MK,
    5. Ahmad N,
    6. Raza K
    . Multitargeted molecular dynamic understanding of butoxypheser against SARS-CoV-2: an insilico study. [Updated 2022; 2023 Apr 10]. Available from: https://journals.sagepub.com/doi/10.1177/1934578X221115499
  35. 35.↵
    1. Maddison WP
    . Gene trees in species trees. Syst Biol 1997; 46: 523-536.
    OpenUrlCrossRefWeb of Science
  36. 36.↵
    1. Hecht MK,
    2. Edwards JL
    . The methodology of phylogenetic inference above the species level. NSSB 1977; 14: 3-51.
    OpenUrl
  37. 37.↵
    1. Hirschhaeuser F,
    2. Sattler UG,
    3. Mueller-Klieser W
    . Lactate: a metabolic key player in cancer. Cancer Res 2011; 71: 6921-6925.
    OpenUrlAbstract/FREE Full Text
  38. 38.↵
    1. Vander Heiden MG,
    2. Cantley LC,
    3. Thompson CB
    . Understanding the warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324: 1029-1033.
    OpenUrlAbstract/FREE Full Text
  39. 39.↵
    1. Hirabayashi S,
    2. Baranski TJ,
    3. Cagan RL
    . Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell 2013; 154: 664-675.
    OpenUrlCrossRefPubMed
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Ras-related associated with diabetes genes for biomarker-based therapeutics in cancer
Mohammed A. Hakami
Saudi Medical Journal Feb 2024, 45 (2) 111-120; DOI: 10.15537/smj.2024.45.2.20230564

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Ras-related associated with diabetes genes for biomarker-based therapeutics in cancer
Mohammed A. Hakami
Saudi Medical Journal Feb 2024, 45 (2) 111-120; DOI: 10.15537/smj.2024.45.2.20230564
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Keywords

  • RRAD
  • diabetes
  • SSRs
  • transcription factors
  • phylogenomic
  • comparative annotations

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