Investigation of hematologic findings related to brucellosis in Anatolian region

Article Figures & Data

Table 1

- Distribution of age and laboratory parameters according to stage.

Variables	Acute		Subacute		Chronic		Relapse		P-values^*
Variables	Median	Mean±SD	Median	Mean±SD	Median	Mean±SD	Median	Mean±SD	P-values^*
Age	41.00	42.28±15.77	44.00	44.91±15.75	51.50	50.57±15.49	45.00	45.97±16.25	<0.001
Wbc	7.00	7.28±2.38	7.18	7.54±2.46	7.06	7.45±2.31	6.91	7.16±2.12	0.015
Hgb	13.50	13.40±1.81	13.50	13.57±1.84	13.50	13.50±2.03	13.30	13.34±1.74	0.278
Neut	3.62	4.06±1.97	3.94	4.32±2.14	3.86	4.34±1.98	3.84	4.10±1.74	<0.001
Lymp	2.32	2.45±0.97	2.28	2.43±1.06	2.22	2.34±0.85	2.19	2.30±0.76	0.272
Mono	0.55	0.59±0.25	0.53	0.59±0.25	0.50	0.54±0.19	0.49	0.54±0.21	0.001
MPV	9.40	9.37±1.33	9.50	9.47±1.36	9.50	9.50±1.38	9.80	9.75±1.25	<0.001
Eos	0.08	0.11±0.12	0.10	0.14±0.15	0.13	0.17±0.15	0.13	0.16±0.13	<0.001
Plt	252.00	259.77±84.22	249.00	263.13±86.07	264.00	269.13±68.82	253.00	264.01±77.64	0.008

Values are presented as median and mean ± standard deviation (SD).
↵* Kruskall Wallis.
Wbc: white blood cell, Hgb: hemoglobin, Neut: neutrophil, Lymp: lymphocyte, MPV: mean platelet volume, Plt: platelet, Eos: eosinophil

Table 2

- Analysis of age and laboratory parameters of patients.

Variables	Median		Mean±SD		P-values^*
	Female	Male	Female	Male
Age	45.0	41.0	45.57±15.77)	42.58±16.00)	<0.001
Wbc	6.9	7.2	7.11±2.13)	7.60±2.57)	<0.001
Hgb	12.7	14.4	12.63±1.54)	14.23±1.74)	<0.001
Neut	3.8	3.8	3.99±1.73)	4.31±2.23)	0.004
Lymp	2.3	2.3	2.38±0.94)	2.46±1.01)	0.007
Mono	0.5	0.6	0.53±0.20)	0.62±0.28)	<0.001
MPV	9.6	9.4	9.62±1.33)	9.28±1.33)	<0.001
Eos	0.1	0.1	0.13±0.13)	0.13±0.14)	0.482
Plt	259.5	245.0	270.04±83.45)	254.16±82.01)	<0.001

Values are presented as median and mean ± standard deviatin (SD).
↵* Pairwise comparisons were carried out between genders using Mann Whitney-U test.
Wbc: white blood cell, Hgb: hemoglobin, Neut: neutrophil, Lymp: lymphocyte, MPV: mean platelet volume, Plt: platelet, Eos: eosinophil

Table 3

- Hematological findings of patients.

Findings	Acute (n=1916)			Subacute (n=981)			Chronic (n=260)			Relapse (n=315)			Total (N=3472)			P-values (group)^‡
Findings	n	% of total^*	% of group^†	n	% of total^*	% of group^†	n	% of total^*	% of group^†	n	% of total^*	% of group^†	n	% of total^*	% of group^†	P-values (group)^‡
Anemia	516	14.9	26.9	251	7.2	25.6	69	2.0	26.5	63	1.8	20.0	899	25.9	25.9	0.076
Leukocytosis	143	4.1	7.5	68	2.0	6.9	19	0.5	7.3	17	0.5	5.4	247	7.1	7.1	0.610
Leukopenia	94	2.7	4.9	36	1.0	3.7	8	0.2	3.1	12	0.3	3.8	150	4.3	4.3	0.288
Neutropenia	46	1.3	2.4	19	0.5	1.9	1	0.0	0.4	8	0.2	2.5	74	2.1	2.1	0.179
Neutrophilia	100	2.9	5.2	55	1.6	5.6	10	0.3	3.8	13	0.4	4.1	178	5.1	5.1	0.568
Lymphopenia	74	2.1	3.9	36	1.0	3.7	7	0.2	2.7	8	0.2	2.5	125	3.6	3.6	0.566
Lymphocytosis	118	3.4	6.2	63	1.8	6.4	10	0.3	3.8	10	0.3	3.2	201	5.8	5.8	0.074
Monocytopenia	86	2.5	4.5	35	1.0	3.6	3	0.1	1.2	8	0.2	2.6	132	3.8	3.8	0.030
Monocytosis	342	10.0	18.1	146	4.3	14.9	23	0.7	9.0	35	1.0	11.3	546	15.9	15.9	<0.001
Thrombocytopenia	169	4.9	8.8	54	1.6	5.5	7	0.2	2.7	12	0.3	3.8	242	7.0	7.0	<0.001
Thrombocytosis	45	1.3	2.3	23	0.7	2.3	1	0.0	0.4	11	0.3	3.5	80	2.3	2.3	0.100
Eosinophilia	22	0.7	1.3	35	1.1	3.8	8	0.3	3.2	10	0.3	3.4	75	2.4	2.4	<0.001
Eosinopenia	233	7.3	13.6	72	2.3	7.8	8	0.3	3.3	15	0.5	5.2	328	10.3	10.3	<0.001
Pancytopenia	17	0.5	0.9	9	0.3	0.9	0	0.0	0.0	3	0.1	1.0	29	0.8	0.8	0.496
Bicytopenia	96	2.8	5.0	39	1.1	4.0	7	0.2	2.7	8	0.2	2.5	150	4.3	4.3	0.086

Values are presented as numbers and percentages (%).
↵* Percentage of occurrence in all patients.
↵† Percentage of occurrence in disease stage.
↵‡ The relationship between the presence of pathologic findings and disease stages.