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Research ArticleOriginal Article
Open Access

Concordance between homeostatic model assessment and triglyceride glucose index in assessing insulin resistance among HIV-infected patients

Gokcen Gurkok Budak, Aslı Vatan, Ertuğrul Güçlü and Oğuz Karabay
Saudi Medical Journal February 2025, 46 (2) 157-162; DOI: https://doi.org/10.15537/smj.2025.46.2.20240769
Gokcen Gurkok Budak
From the Department of Infectious Diseases and Clinical Microbiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
MD, PhD
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  • ORCID record for Gokcen Gurkok Budak
  • For correspondence: [email protected]
Aslı Vatan
From the Department of Infectious Diseases and Clinical Microbiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
MD
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Ertuğrul Güçlü
From the Department of Infectious Diseases and Clinical Microbiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
MD
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Oğuz Karabay
From the Department of Infectious Diseases and Clinical Microbiology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
MD
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  • Figure 1
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    Figure 1

    - The positive correlation between TyG (triglyceride glucose) index TyG and HOMA-IR. HOMA-IR: homeostatic model assessment of insulin resistance

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    Figure 2

    - Receiver operating characteristic (ROC) curve of triglyceride glucose index for predicting insulin resistance.

Tables

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    Table 1

    - Characteristics of the subjects (N=147).

    ParametersGroup AGroup BP-value
    Female / Male8(11.1)/64(88.9)20(26.7)/55(73.3)0.016a
    CD4 <250 / >250cell/mm318(25.0)/54(75.0)27(36.0)/48(64.0)0.148a
    RNA <5000 / >5000copy/ml28(38.9)/44(61.1)18(24.0)/57(76.0)0.052a
    BMI <25/>2556(77.8)/16(22.2)62(82.7)/13(17.3)0.457a
    Age30 (19-67)35(18-68)0.153c
    Triglycerid120 (50-280)162(100-310)<0.001c
    TyG index8.112±0.2578.43±0.231<0.001b
    Glucose69.47±14.91180.64±14.965<0.001b
    • ↵a Pearson Chi-Square test; n (%),

    • ↵b Independent sample t test; mean±standard deviation,

    • ↵c Mann-Whitney U test; median (min-max)

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    Table 2

    - Risk factors of insulin resistance through binary logistic regression analysis.

    ParametersUnivariateMultiple
    OR (%95 CI)P-value*OR (%95 CI)P-value*
    Gender (male)2.9 (1.2-7.1)0.0194.8 (1.5-16.1)0.019
    Age1.0 (0.99-1.04)0.221- 
    CD4 (>250 cell-mm3)1.7 (0.8-3.4)0.150- 
    RNA (>5000 copy-ml)0.5 (0.2-1.01)0.053- 
    BMI (>25)1.4 (0.6-3.1)0.45710.8 (2.8-41.9)<0.001
    Triglyceride glucose-index235 (34.5-1599)<0.001- 
    Triglyceride1.03 (1.02-1.04)<0.001- 
    Glucose1.05 (1.02-1.08)<0.001- 

    OR: odds ratio; CI: confidence interval, BMI: body mass index

      • View popup
      Table 3

      - TyG Index value for predicting IR.

      ParametersGroup AGroup BP-value
      TyG <8.2550 (69.4)17 (22.7)<0.001
      TyG> 8.2522 (30.6)58 (77.3)

      IR: insulin resistance, TyG: triglyceride glucose

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      1 Feb 2025
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      Concordance between homeostatic model assessment and triglyceride glucose index in assessing insulin resistance among HIV-infected patients
      Gokcen Gurkok Budak, Aslı Vatan, Ertuğrul Güçlü, Oğuz Karabay
      Saudi Medical Journal Feb 2025, 46 (2) 157-162; DOI: 10.15537/smj.2025.46.2.20240769

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      Concordance between homeostatic model assessment and triglyceride glucose index in assessing insulin resistance among HIV-infected patients
      Gokcen Gurkok Budak, Aslı Vatan, Ertuğrul Güçlü, Oğuz Karabay
      Saudi Medical Journal Feb 2025, 46 (2) 157-162; DOI: 10.15537/smj.2025.46.2.20240769
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      Keywords

      • HIV
      • insulin resistance
      • triglyceride glucose index

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