Antioxidant effect of vitamin E and 5-aminosalicylic acid on acrylamide induced kidney injury in rats

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Figure 1
Effect of acrylamide (ACR) and antioxidants 5-aminosalicylic acid (ASA), vitamin E (vit-E), on body weight changes and lactate dehydrogenase activity, LDH - lactate dehydrogenase.
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Figure 2
Sections of kidneys isolated from: A) control adult rat, with normal Bowman’s space. B& C& E) acrylamide treated rat, B) Shows protein casts (arrows) in the lumen of the tubule with tubular degeneration C) Shows segmental duplication of the glomerular basement membrane together with endothelial swelling D) High power view, shows extensive tubular damage, with, cytoplasmic hyperoesinophilia, enlarged hyperchromatic nuclei (arrows) and nucleoli E) acrylamide +5-aminosalycylic acid treated rat, Shows good protection of the kidney with normal renal corpuscles and minimal congestion and F) acrylamide + 5-aminosalicylic acid + vitamin-E treated rat. Shows protection with minimal tubular dilatation. All sections were stained with H&E stain and viewed with light microscopy.