Research ArticleOriginal Article
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Diabetes mellitus as a comorbidity in COVID-19 infection in the United Arab Emirates

Noha M. Elemam, Haifa Hannawi, Issa Al Salmi, Kashif Bin Naeem, Fahdah Alokaily and Suad Hannawi
Saudi Medical Journal February 2021, 42 (2) 170-180; DOI: https://doi.org/10.15537/smj.2021.2.25700

References

  1. 1.↵
    1. Velavan TP,
    2. Meyer CG.
    The COVID-19 epidemic. Trop Med Int Health 2020; 25: 278-280.
    OpenUrlPubMed
  2. 2.↵
    1. Wang C,
    2. Horby PW,
    3. Hayden FG,
    4. Gao GF.
    A novel coronavirus outbreak of global health concern. The Lancet 2020; 395: 470-473.
    OpenUrlCrossRef
  3. 3.↵
    1. Li W,
    2. Moore MJ,
    3. Vasilieva N,
    4. Sui J,
    5. Wong SK,
    6. Berne MA, et al.
    Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003; 426: 450-454.
    OpenUrlCrossRefPubMed
  4. 4.
    1. Yan R,
    2. Zhang Y,
    3. Li Y,
    4. Xia L,
    5. Guo Y,
    6. Zhou Q.
    Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science 2020; 367: 1444.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Huang C,
    2. Wang Y,
    3. Li X,
    4. Ren L,
    5. Zhao J,
    6. Hu Y, et al.
    Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England) 2020; 395: 497-506.
    OpenUrl
  6. 6.↵
    1. Hoffmann M,
    2. Kleine-Weber H,
    3. Schroeder S,
    4. Krüger N,
    5. Herrler T,
    6. Erichsen S, et al.
    SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020; 181: 271-80.e8.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Zhao Y,
    2. Zhao Z,
    3. Wang Y,
    4. Zhou Y,
    5. Ma Y,
    6. Zuo W.
    Single-cell RNA expression profiling of ACE2, the receptor of SARS-CoV-2. bioRxiv 2020: 2020.01.26.919985.
  8. 8.↵
    1. Guan WJ,
    2. Ni ZY,
    3. Hu Y,
    4. Liang WH,
    5. Ou CQ,
    6. He JX, et al.
    Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv 2020: 2020.02.06.20020974.
  9. 9.
    1. Chen F,
    2. Liu ZS,
    3. Zhang FR,
    4. Xiong RH,
    5. Chen Y,
    6. Cheng XF, et al.
    [First case of severe childhood novel coronavirus pneumonia in China]. Zhonghua Er Ke Za Zhi 2020; 58: E005. Chinese.
    OpenUrl
  10. 10.
    1. Marotto D,
    2. Sarzi-Puttini P.
    What is the role of rheumatologists in the era of COVID-19? Autoimmun Rev 2020; 19: 102539.
    OpenUrl
  11. 11.↵
    1. Qin C,
    2. Zhou L,
    3. Hu Z,
    4. Zhang S,
    5. Yang S,
    6. Tao Y, et al.
    Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis 2020; 71: 762-768.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Ponti G,
    2. Maccaferri M,
    3. Ruini C,
    4. Tomasi A,
    5. Ozben T.
    Biomarkers associated with COVID-19 disease progression. Crit Rev Clin Lab Sci 2020; 57: 389-399.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Guo W,
    2. Li M,
    3. Dong Y,
    4. Zhou H,
    5. Zhang Z,
    6. Tian C, et al.
    Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev 2020; 31: e3319.
    OpenUrl
  14. 14.↵
    1. Zhou F,
    2. Yu T,
    3. Du R,
    4. Fan G,
    5. Liu Y,
    6. Liu Z, et al.
    Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (London, England) 2020; 395: 1054-1062.
    OpenUrl
  15. 15.↵
    1. Deng S-Q,
    2. Peng H-J.
    Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China. J Clin Med 2020; 9: 575.
    OpenUrl
  16. 16.↵
    1. Yang JK,
    2. Lin SS,
    3. Ji XJ,
    4. Guo LM.
    Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol 2010; 47: 193-199
    OpenUrlCrossRefPubMed
  17. 17.↵
    Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death. N Engl J Med 2011; 364: 829-841.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Wu J,
    2. Li W,
    3. Shi X,
    4. Chen Z,
    5. Jiang B,
    6. Liu J, et al.
    Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19). J Intern Med 2020; 288: 128-138.
    OpenUrlCrossRef
  19. 19.↵
    1. Casqueiro J,
    2. Casqueiro J,
    3. Alves C.
    Infections in patients with diabetes mellitus: A review of pathogenesis. Indian J Endocrinol Metab 2012; 16 Suppl 1: S27-S36.
    OpenUrl
  20. 20.↵
    1. Cristelo C,
    2. Azevedo C,
    3. Marques JM,
    4. Nunes R,
    5. Sarmento B.
    SARS-CoV-2 and diabetes: New challenges for the disease. Diabetes Res Clin Pract 2020; 164: 108228.
    OpenUrlPubMed
  21. 21.↵
    1. Shah S,
    2. Sonawane P,
    3. Nahar P,
    4. Vaidya S,
    5. Salvi S.
    Pulmonary function tests in type 2 diabetes mellitus and their association with glycemic control and duration of the disease. Lung India 2013; 30: 108-112.
    OpenUrlCrossRefPubMed
  22. 22.↵
    International Diabetes Federation. Prevalence of diabetes. [Updated 2020; Accessed dated ????]. Available from: https://idf.org/our-network/regions-members/middle-east-and-north-africa/members/49-united-arab-emirates.html.
  23. 23.↵
    1. Hamoudi R,
    2. Saheb Sharif-Askari N,
    3. Saheb Sharif-Askari F,
    4. Abusnana S,
    5. Aljaibeji H,
    6. Taneera J, et al.
    Prediabetes and diabetes prevalence and risk factors comparison between ethnic groups in the United Arab Emirates. Sci Rep 2019; 9: 17437.
    OpenUrl
  24. 24.↵
    1. Huang H,
    2. Cai S,
    3. Li Y,
    4. Li Y,
    5. Fan Y,
    6. Li L, et al.
    Prognostic factors for COVID-19 pneumonia progression to severe symptoms based on earlier clinical features: A retrospective analysis. Front Med (Lausanne) 2020; 7: 557453.
    OpenUrl
  25. 25.↵
    1. Soro-Paavonen A,
    2. Gordin D,
    3. Forsblom C,
    4. Rosengard-Barlund M,
    5. Waden J,
    6. Thorn L, et al.
    Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications. J Hypertens 2012; 30: 375-383.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.↵
    1. Bindom SM,
    2. Hans CP,
    3. Xia H,
    4. Boulares AH,
    5. Lazartigues E.
    Angiotensin I-converting enzyme type 2 (ACE2) gene therapy improves glycemic control in diabetic mice. Diabetes 2010; 59: 2540-2548.
    OpenUrlAbstract/FREE Full Text
  27. 27.↵
    1. Ferrario CM,
    2. Jessup J,
    3. Chappell MC,
    4. Averill DB,
    5. Brosnihan KB,
    6. Tallant EA, et al.
    Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation 2005; 111: 2605-2610.
    OpenUrlAbstract/FREE Full Text
  28. 28.↵
    1. Jin JM,
    2. Bai P,
    3. He W,
    4. Wu F,
    5. Liu X-F,
    6. Han D-M, et al.
    Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Front Public Health 2020; 8: 152.
    OpenUrl
  29. 29.↵
    1. Mauvais-Jarvis F.
    Aging, male sex, obesity, and metabolic inflammation create the perfect storm for COVID-19. Diabetes 2020; 69: 1857-1863.
    OpenUrlAbstract/FREE Full Text
  30. 30.↵
    1. Martos Pérez F,
    2. Luque Del Pino J,
    3. Jiménez García N,
    4. Mora Ruiz E,
    5. Asencio Méndez C,
    6. García Jiménez JM, et al.
    Comorbidity and prognostic factors on admission in a COVID-19 cohort of a general hospital. Rev Clin Esp (Barc) 2020;Aug: 32680592.
  31. 31.↵
    1. Zhou W,
    2. Ye S,
    3. Wang W,
    4. Li S,
    5. Hu Q.
    Clinical features of COVID-19 Patients with diabetes and secondary hyperglycemia. J Diabetes Res 2020; 2020: 3918723.
    OpenUrl
  32. 32.↵
    1. Sardu C,
    2. Gargiulo G,
    3. Esposito G,
    4. Paolisso G,
    5. Marfella R.
    Impact of diabetes mellitus on clinical outcomes in patients affected by Covid-19. Cardiovasc Diabetol 2020; 19: 76.
    OpenUrl
  33. 33.↵
    1. Yao Y,
    2. Cao J,
    3. Wang Q,
    4. Shi Q,
    5. Liu K,
    6. Luo Z, et al.
    D-dimer as a biomarker for disease severity and mortality in COVID-19 patients: a case control study. J Intensive Care 2020; 8: 49.
    OpenUrlCrossRef
  34. 34.↵
    1. Zaki N,
    2. Alashwal H,
    3. Ibrahim S.
    Association of hypertension, diabetes, stroke, cancer, kidney disease, and high-cholesterol with COVID-19 disease severity and fatality: A systematic review. Diabetes Metab Syndr 2020; 14: 1133-1142.
    OpenUrlCrossRef
  35. 35.↵
    1. Soliman AT,
    2. Prabhakaran Nair A,
    3. Al Masalamani MS,
    4. De Sanctis V,
    5. Abu Khattab MA,
    6. Alsaud AE, et al.
    Prevalence, clinical manifestations, and biochemical data of type 2 diabetes mellitus versus nondiabetic symptomatic patients with COVID-19: A comparative study. Acta Bio Medica Atenei Parmensis 2020; 91: e2020010.
    OpenUrl
  36. 36.↵
    1. Shang J,
    2. Wang Q,
    3. Zhang H,
    4. Wang X,
    5. Wan J,
    6. Yan Y, et al.
    The Relationship between Diabetes Mellitus and COVID-19 Prognosis: A Retrospective Cohort Study in Wuhan, China. Am J Med 2021; 134: e6-e14.
    OpenUrl
  37. 37.↵
    1. Terpos E,
    2. Ntanasis-Stathopoulos I,
    3. Elalamy I,
    4. Kastritis E,
    5. Sergentanis TN,
    6. Politou M, et al.
    Hematological findings and complications of COVID-19. Am J Hematol 2020; 95: 834-847.
    OpenUrlCrossRefPubMed
  38. 38.
    1. Kermali M,
    2. Khalsa RK,
    3. Pillai K,
    4. Ismail Z,
    5. Harky A.
    The role of biomarkers in diagnosis of COVID-19 - A systematic review. Life Sci 2020; 254: 117788.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. Ferrari D,
    2. Motta A,
    3. Strollo M,
    4. Banfi G,
    5. Locatelli M.
    Routine blood tests as a potential diagnostic tool for COVID-19. Clin Chem Lab Med 2020; 58: 1095-1099.
    OpenUrl
  40. 40.↵
    1. Vargas-Vargas M,
    2. Cortés-Rojo C.
    Ferritin levels and COVID-19. Rev Panam Salud Publica 2020; 44: e72.
    OpenUrl
  41. 41.↵
    1. Wang D,
    2. Hu B,
    3. Hu C,
    4. Zhu F,
    5. Liu X,
    6. Zhang J, et al.
    Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA 2020; 323: 1061-1069.
    OpenUrlCrossRefPubMed
  42. 42.↵
    1. Taneri PE,
    2. Gomez-Ochoa SA,
    3. Llanaj E,
    4. Raguindin PF,
    5. Rojas LZ,
    6. Wyssmann BM, et al.
    Anemia and iron metabolism in COVID-19: A systematic review and meta-analysis. medRxiv 2020; 2020.06.04.20122267.
  43. 43.↵
    1. Kwon E,
    2. Ahn C.
    Low hemoglobin concentration is associated with several diabetic profiles. Korean J Intern Med 2012; 27: 273-274.
    OpenUrlPubMed
  44. 44.↵
    1. English E,
    2. Idris I,
    3. Smith G,
    4. Dhatariya K,
    5. Kilpatrick ES,
    6. John WG.
    The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review. Diabetologia 2015; 58: 1409-1421.
    OpenUrlCrossRefPubMed
  45. 45.↵
    1. Henry BM,
    2. Lippi G.
    Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection. Int Urol Nephrol 2020; 52: 1193-1194.
    OpenUrlCrossRefPubMed
  46. 46.↵
    1. Narva AS,
    2. Bilous RW.
    Laboratory assessment of diabetic kidney disease. Diabetes Spectr 2015; 28: 162-166.
    OpenUrlAbstract/FREE Full Text
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