Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Elevated levels of CD56+ T Cells, CD16+ CD56+ T Cells, and CD56dim NK Cells in herpes simplex virus type 1 seropositive healthy individuals

Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Meshari A. Alsuwat and Mustafa Halawi
Saudi Medical Journal December 2024, 45 (12) 1312-1317; DOI: https://doi.org/10.15537/smj.2024.45.12.20240498
Mazen Almehmadi
From the Department of Clinical Laboratory Sciences (Almehmadi, Allahyani, Aljuaid, Alsuwat), College of Applied Medical Sciences, Taif University, Taif; and from the College of Nursing and Health Sciences (Halawi), Jazan University, Jazan, Kingdom of Saudi Arabia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Mazen Almehmadi
  • For correspondence: [email protected]
Mamdouh Allahyani
From the Department of Clinical Laboratory Sciences (Almehmadi, Allahyani, Aljuaid, Alsuwat), College of Applied Medical Sciences, Taif University, Taif; and from the College of Nursing and Health Sciences (Halawi), Jazan University, Jazan, Kingdom of Saudi Arabia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abdulelah Aljuaid
From the Department of Clinical Laboratory Sciences (Almehmadi, Allahyani, Aljuaid, Alsuwat), College of Applied Medical Sciences, Taif University, Taif; and from the College of Nursing and Health Sciences (Halawi), Jazan University, Jazan, Kingdom of Saudi Arabia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Meshari A. Alsuwat
From the Department of Clinical Laboratory Sciences (Almehmadi, Allahyani, Aljuaid, Alsuwat), College of Applied Medical Sciences, Taif University, Taif; and from the College of Nursing and Health Sciences (Halawi), Jazan University, Jazan, Kingdom of Saudi Arabia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mustafa Halawi
From the Department of Clinical Laboratory Sciences (Almehmadi, Allahyani, Aljuaid, Alsuwat), College of Applied Medical Sciences, Taif University, Taif; and from the College of Nursing and Health Sciences (Halawi), Jazan University, Jazan, Kingdom of Saudi Arabia.
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Arduino PG,
    2. Alovisi M,
    3. Petti S.
    Herpes simplex virus type 1 in periapical pathoses: Systematic review and meta-analysis. Oral Dis 2024; 30: 865–876.
    OpenUrlPubMed
  2. 2.↵
    1. Arduino PG,
    2. Cabras M,
    3. Lodi G,
    4. Petti S.
    Herpes simplex virus type 1 in subgingival plaque and periodontal diseases. Meta-analysis of observational studies. J Periodontal Res 2022; 57: 256–268.
    OpenUrlPubMed
  3. 3.↵
    1. Piperi E,
    2. Papadopoulou E,
    3. Georgaki M,
    4. Dovrat S,
    5. Bar Illan M,
    6. Nikitakis NG, et al.
    Management of oral herpes simplex virus infections: The problem of resistance. A narrative review. Oral Dis 2024; 30: 877–894.
    OpenUrlPubMed
  4. 4.↵
    1. Laing KJ,
    2. Campbell VL,
    3. Dong L,
    4. Koelle DM.
    HLA-B*57:01 Complexed to a CD8 T-Cell Epitope from the HSV-2 ICP22 Protein Binds NK and T Cells through KIR3DL1. Viruses 2022; 14: 1019.
    OpenUrlPubMed
  5. 5.↵
    1. Almehmadi M,
    2. Flanagan BF,
    3. Khan N,
    4. Alomar S,
    5. Christmas SE.
    Increased numbers and functional activity of CD56+ T cells in healthy cytomegalovirus positive subjects. Immunology 2014; 142: 258-268.
    OpenUrlCrossRef
  6. 6.↵
    1. Almehmadi M,
    2. Hammad A,
    3. Heyworth S,
    4. Moberly J,
    5. Middleton D,
    6. Hopkins MJ, et al.
    CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infection. Transpl Infect Dis 2015; 17: 518-526.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Cohen PR.
    Clinical features of atypical presentations of mucocutaneous herpes simplex virus infection observed in immunosuppressed individuals. Part II: the knife-cut sign. Dermatol Online J 2024; 30.
  8. 8.↵
    1. Alshammari A,
    2. Alotaibi J,
    3. Almaghrabi R,
    4. Bawazeer R,
    5. Althawadi S,
    6. Tayeb H.
    First parechovirus reported case in Saudi Arabia in hospitalized immunocompromised adult patient. Virol J 2024; 21: 102.
    OpenUrlPubMed
  9. 9.↵
    1. Razizadeh MH,
    2. Zafarani A,
    3. Taghavi-Farahabadi M,
    4. Khorramdelazad H,
    5. Minaeian S,
    6. Mahmoudi M.
    Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we? Cell Commun Signal 2023; 21: 1–22.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. La Rosa F,
    2. Agostini S,
    3. Bianchi A,
    4. Nemni R,
    5. Piancone F,
    6. Marventano I, et al.
    Herpes simplex virus-1 (HSV-1) infection induces a potent but ineffective IFN-λ production in immune cells of AD and PD patients. J Transl Med 2019; 17: 1–-0.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Memish ZA,
    2. Almasri M,
    3. Chentoufi AA,
    4. Al-Tawfiq JA,
    5. Al-Shangiti AM,
    6. Al-Kabbani KM, et al.
    Seroprevalence of Herpes simplex virus type 1 and type 2 and coinfection with hiv and syphilis: The First National Seroprevalence Survey in Saudi Arabia. Sex Transm Dis 2015; 42: 526-532.
    OpenUrlPubMed
  12. 12.↵
    1. Taha AE,
    2. Ghazy A,
    3. Almaeen A,
    4. Taher I,
    5. El-Metwally T,
    6. Alayyaf MA, et al.
    Estimation of Seroprevalence of Anti-Herpes Simplex Virus Type-1 IgG Among Healthy Blood Donors in Sakaka City, Aljouf, Saudi Arabia. J Med Virol 2023; 16: 136606.
    OpenUrl
  13. 13.↵
    1. Leinweber B,
    2. Kerl H,
    3. Cerroni L.
    Histopathologic features of cutaneous herpes virus infections (herpes simplex, herpes varicella/zoster): A broad spectrum of presentations with common pseudolymphomatous aspects. Am J Surg Pathol 2006;30: 50–58.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Almehmadi M,
    2. Hammad A,
    3. Heyworth S,
    4. Moberly J,
    5. Middleton D,
    6. Hopkins MJ, et al.
    CD56+ T cells are increased in kidney transplant patients following cytomegalovirus infection. Transplant Infectious Disease 2015 1;17: 518–526.
    OpenUrl
  15. 15.↵
    1. Quatrini L,
    2. Della Chiesa M,
    3. Sivori S,
    4. Mingari MC,
    5. Pende D,
    6. Moretta L.
    Human NK cells, ptors and function. Eur J Immunol 2021; 51: 1566-1579.
    OpenUrlPubMed
  16. 16.
    1. Schneider CL,
    2. Hudson AW.
    The Human Herpesvirus-7 (HHV-7) U21 Immunoevasin Subverts NK-Mediated Cytoxicity through Modulation of MICA and MICB. PLoS Pathog 2011; 7: 1002362.
    OpenUrl
  17. 17.
    1. Campbell TM,
    2. McSharry BP,
    3. Steain M,
    4. Slobedman B,
    5. Abendroth A.
    Varicella-zoster virus and herpes simplex virus 1 differentially modulate NKG2D Ligand Expression during productive infection. J Virol 2015; 89: 7932.
    OpenUrlAbstract/FREE Full Text
  18. 18.↵
    1. Carter C,
    2. Savic S,
    3. Cole J,
    4. Wood P.
    Natural killer cell receptor expression in patients with severe and recurrent Herpes simplex virus-1 (HSV-1) infections. Cell Immunol 2007; 246: 65–74.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Lenart M,
    2. Kluczewska A,
    3. Szaflarska A,
    4. Rutkowska-Zapała M,
    5. Wąsik M,
    6. Ziemiańska-Pięta A, et al.
    Selective downregulation of natural killer activating receptors on NK cells and upregulation of PD-1 expression on T cells in children with severe and/or recurrent Herpes simplex virus infections. Immunobiology 2021; 226: 152097.
    OpenUrlPubMed
  20. 20.↵
    1. Li T,
    2. Yan GL,
    3. Luo Z,
    4. Xie Q,
    5. Lai MM,
    6. Chen ZG, et al.
    Chronic Pediatric Immune Thrombocytopenia Is Not Associated With Herpes Virus Infection Status. Front Pediatr 2021; 9: 641535.
    OpenUrlPubMed
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 45 (12)
Saudi Medical Journal
Vol. 45, Issue 12
1 Dec 2024
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Elevated levels of CD56+ T Cells, CD16+ CD56+ T Cells, and CD56dim NK Cells in herpes simplex virus type 1 seropositive healthy individuals
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Elevated levels of CD56+ T Cells, CD16+ CD56+ T Cells, and CD56dim NK Cells in herpes simplex virus type 1 seropositive healthy individuals
Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Meshari A. Alsuwat, Mustafa Halawi
Saudi Medical Journal Dec 2024, 45 (12) 1312-1317; DOI: 10.15537/smj.2024.45.12.20240498

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Elevated levels of CD56+ T Cells, CD16+ CD56+ T Cells, and CD56dim NK Cells in herpes simplex virus type 1 seropositive healthy individuals
Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Meshari A. Alsuwat, Mustafa Halawi
Saudi Medical Journal Dec 2024, 45 (12) 1312-1317; DOI: 10.15537/smj.2024.45.12.20240498
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Assessment of asthma control levels in a tertiary hospital
  • The risk factors for cardiovascular disease and chronic kidney disease in patients with nonalcoholic fatty liver disease in Saudi Arabia
  • Prolonged flight exposure and its effects on sinonasal health among aircrew members
Show more Original Article

Similar Articles

Keywords

  • CD56+
  • T-cells
  • HSV-1

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire