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Research ArticleOriginal Article
Open Access

The effect of injectable platelet-rich fibrin in combination with autogenous bone grafts on bone healing in an ovariectomized osteoporotic rat model with critical-sized defects

Mustafa C. Durmuşlar, Elif A. Gülşen, Kemal A. Bayburt, Umut Ballı, Mert Ocak, Ayşegül Fırat, Elham B. Zırh and Hakan H. Çelik
Saudi Medical Journal August 2024, 45 (8) 791-798; DOI: https://doi.org/10.15537/smj.2024.45.8.20240224
Mustafa C. Durmuşlar
From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
DDS, PhD
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  • ORCID record for Mustafa C. Durmuşlar
  • For correspondence: [email protected]
Elif A. Gülşen
From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
DDS, PhD
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Kemal A. Bayburt
From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
DDS, PhD
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Umut Ballı
From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
DDS, PhD
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Mert Ocak
From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
PhD
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Ayşegül Fırat
From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
MD, PhD
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Elham B. Zırh
From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
PhD
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Hakan H. Çelik
From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
MD, PhD
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Article Information

vol. 45 no. 8 791-798
DOI 
https://doi.org/10.15537/smj.2024.45.8.20240224
PubMed 
39074896

Published By 
Saudi Medical Journal
Online ISSN 
1658-3175
History 
  • Received March 19, 2024
  • Accepted June 14, 2024
  • Published online July 28, 2024.

Copyright & Usage 
Copyright: © Saudi Medical Journal This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

Author Information

  1. Mustafa C. Durmuşlar, DDS, PhD⇑,
  2. Elif A. Gülşen, DDS, PhD,
  3. Kemal A. Bayburt, DDS, PhD,
  4. Umut Ballı, DDS, PhD,
  5. Mert Ocak, PhD,
  6. Ayşegül Fırat, MD, PhD,
  7. Elham B. Zırh, PhD and
  8. Hakan H. Çelik, MD, PhD
  1. From the Department of Oral and Maxillofacial Surgery (Durmuşlar, Bayburt), Faculty of Dentistry Biruni University, Istanbul, from the Department of Oral and Maxillofacial Surgery (Gülşen), Ibn-i Sina Campus Faculty of Dentistry Bulent Ecevit University Esenkoy, Zonguldak, from the Department of Periodontology (Ballı), Adana Yüreğir Karşıyaka Oral and Dental Health Hospital, Adana, from the Department of Basic Medical Sciences, Anatomy (Ocak), Faculty of Dentistry, Ankara University, from the Department of Anatomy (Fırat, Çelik), Faculty of Medicine, Hacettepe University, and from the Department of Histology and Embryology (Zırh), Faculty of Medicine, TOBB University of Economics and Tecnology, Ankara, Turkey.
  1. Address correspondence and reprint request to: Dr. Mustafa C. Durmuşlar, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Biruni University, Istanbul, Turkey. E-mail: mdurmuslar{at}biruni.edu.tr
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The effect of injectable platelet-rich fibrin in combination with autogenous bone grafts on bone healing in an ovariectomized osteoporotic rat model with critical-sized defects
Mustafa C. Durmuşlar, Elif A. Gülşen, Kemal A. Bayburt, Umut Ballı, Mert Ocak, Ayşegül Fırat, Elham B. Zırh, Hakan H. Çelik
Saudi Medical Journal Aug 2024, 45 (8) 791-798; DOI: 10.15537/smj.2024.45.8.20240224

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The effect of injectable platelet-rich fibrin in combination with autogenous bone grafts on bone healing in an ovariectomized osteoporotic rat model with critical-sized defects
Mustafa C. Durmuşlar, Elif A. Gülşen, Kemal A. Bayburt, Umut Ballı, Mert Ocak, Ayşegül Fırat, Elham B. Zırh, Hakan H. Çelik
Saudi Medical Journal Aug 2024, 45 (8) 791-798; DOI: 10.15537/smj.2024.45.8.20240224
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Keywords

  • animal experiment
  • bone regeneration
  • osteoporosis
  • platelet rich fibrin

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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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